HDAC4 (internal)Rabbit anti-Human, Polyclonal, Rockland™

Description

• Store vial at -20°C prior to opening
• Aliquot contents and freeze at -20°C or below for extended storage
• Avoid cycles of freezing and thawing
• Centrifuge product if not completely clear after standing at room temperature
• This product is stable for several weeks at 4°C as an undiluted liquid
• Dilute only prior to immediate use
• A BLAST analysis was used to suggest cross-reactivity with mouse based on 100% sequence homology
• Cross-reactivity with HDAC4 from other sources has not been determined
• Histone deacetylase 4 (HDAC4) is responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3, and H4)
• Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events
• Histone deacetylases act via the formation of large multiprotein complexes
• HDAC4 is also involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D
• It is also involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer
• Mutations to the HDAC4 gene have been found in Brachydactyly-mental retardation syndrome (BDMR).