HDAC5 (internal)Rabbit anti-Human, Polyclonal, Rockland™

Description

• Store vial at -20°C prior to opening
• Aliquot contents and freeze at -20°C or below for extended storage
• Avoid cycles of freezing and thawing
• Centrifuge product if not completely clear after standing at room temperature
• This product is stable for several weeks at 4°C as an undiluted liquid
• Dilute only prior to immediate use
• A BLAST analysis was used to suggest cross-reactivity with human, mouse, and hamster based on 100% sequence homology
• Cross-reactivity with HDAC5 from other sources has not been determined
• Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events
• Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA
• The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family
• It possesses histone deacetylase activity and represses transcription when tethered to a promoter
• It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins
• It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes
• This gene is thought to be associated with colon cancer
• Two transcript variants encoding different isoforms have been found for this gene.