50-199-3367

Tet2 Monoclonal Antibody (21F11), Active Motif™

Manufacturer: Fischer Scientific

Select a Size

Pack Size SKU Availability Price
Each of 1 50-199-3367-Each-of-1 In Stock ₹ 29,261.52

50-199-3367 - Each of 1

₹ 29,261.52

In Stock

Quantity

1

Base Price: ₹ 29,261.52

GST (18%): ₹ 5,267.074

Total Price: ₹ 34,528.594

Antigen

Tet2

Classification

Monoclonal

Concentration

1 mg/mL

Formulation

PBS with 30% glycerol and 0.035% sodium azide; pH 7.5

Gene Accession No.

Q6N021

Gene Symbols

TET2

Immunogen

This antibody was raised against a recombinant protein corresponding to amino acids 1-300 of human Tet2.

Quantity

50 μg

Primary or Secondary

Primary

Target Species

Human

Product Type

Antibody

Isotype

IgG1 κ

Applications

Immunoprecipitation, Western Blot

Clone

21F11

Conjugate

Unconjugated

Gene

TET2

Gene Alias

Ayu17-449; E130014J05Rik; FLJ20032; KIAA1546; MDS; Methylcytosine dioxygenase TET2; MGC125715; mKIAA1546; Nbla00191; OTTHUMP00000161869; probable methylcytosine dioxygenase TET2; Protein Ayu17 449; Protein Ayu17-449; RGD1311625; Tet 2; tet methylcytosine dioxygenase 2; tet oncogene 2; tet oncogene family member 2; Tet2

Host Species

Mouse

Purification Method

Protein A

Regulatory Status

RUO

Gene ID (Entrez)

54790

Content And Storage

-20°C, Avoid Freeze/Thaw Cycles

Form

Liquid

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Description

  • TET2 is a dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydromethylcytosine (5hmC) and plays a key role in active DNA demethylation
  • TET2 has a preference for 5-hydroxymethylcytosine in CpG motifs
  • It mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC) and conversion of 5fC to 5-carboyxlcytosine (5caC)
  • Conversion of 5mC into 5hmC, 5fC, and 5caC probably constitutes the first step in cytonsine demethylation
  • In addition to TET2’s role in DNA demethylation, it is also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT
  • Mutations in the genes can result in Polycythemia vera and Myelodysplastic syndrome.

Compare Similar Items

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Img

Fischer Scientific

50-199-3367

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Antigen:
Tet2

Classification:
Monoclonal

Concentration:
1 mg/mL

Formulation:
PBS with 30% glycerol and 0.035% sodium azide; pH 7.5

Gene Accession No.:
Q6N021

Gene Symbols:
TET2

Immunogen:
This antibody was raised against a recombinant protein corresponding to amino acids 1-300 of human Tet2.

Quantity:
50 μg

Primary or Secondary:
Primary

Target Species:
Human

Product Type:
Antibody

Isotype:
IgG1 κ

Applications:
Immunoprecipitation, Western Blot

Clone:
21F11

Conjugate:
Unconjugated

Gene:
TET2

Gene Alias:
Ayu17-449; E130014J05Rik; FLJ20032; KIAA1546; MDS; Methylcytosine dioxygenase TET2; MGC125715; mKIAA1546; Nbla00191; OTTHUMP00000161869; probable methylcytosine dioxygenase TET2; Protein Ayu17 449; Protein Ayu17-449; RGD1311625; Tet 2; tet methylcytosine dioxygenase 2; tet oncogene 2; tet oncogene family member 2; Tet2

Host Species:
Mouse

Purification Method:
Protein A

Regulatory Status:
RUO

Gene ID (Entrez):
54790

Content And Storage:
-20°C, Avoid Freeze/Thaw Cycles

Form:
Liquid

Img

Active Motif

50-199-3370

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Antigen:
p300

Classification:
Monoclonal

Concentration:
1 mg/mL

Formulation:
PBS with 30% glycerol and 0.035% sodium azide; pH 7.5

Gene Accession No.:
Q09472

Gene Symbols:
EP300

Immunogen:
The antibody was raised against full-length p300 purified from human 293 cells.

Quantity:
100 μg

Primary or Secondary:
Primary

Target Species:
Human

Product Type:
Antibody

Isotype:
IgG1

Applications:
ChIP Assay, ChIP sequencing (ChIP-seq), Immunocytochemistry, Immunofluorescence

Clone:
NM11

Conjugate:
Unconjugated

Gene:
EP300

Gene Alias:
A430090G16; A730011L11; E1A binding protein p300; E1A-associated protein p300; E1A-binding protein, 300kD; EP300; Histone acetyltransferase p300; Histone butyryltransferase p300; Histone crotonyltransferase p300; KAT3B; P300; p300 HAT; Protein propionyltransferase p300; RSTS2

Host Species:
Mouse

Purification Method:
Protein A

Regulatory Status:
RUO

Gene ID (Entrez):
2033

Content And Storage:
-20°C, Avoid Freeze/Thaw Cycles

Form:
Liquid

Img

Fischer Scientific

50-199-3375

--


Antigen:
RBBP5

Classification:
Polyclonal

Concentration:
Lot-Specific

Formulation:
PBS with 30% glycerol and 0.035% sodium azide; pH 7.5

Gene Accession No.:
Q15291

Gene Symbols:
Rbbp5

Immunogen:
This antibody was raised against a peptide within the C-terminal region of human RBBP5.

Quantity:
100 μL

Primary or Secondary:
Primary

Target Species:
Human

Product Type:
Antibody

Isotype:
IgG

Applications:
ChIP Assay, ChIP sequencing (ChIP-seq), Western Blot

Clone:
__

Conjugate:
Unconjugated

Gene:
Rbbp5

Gene Alias:
4933411J24Rik; BOS_15527; C330016J05; RB binding protein 5, histone lysine methyltransferase complex subunit; RBBP 5; Rbbp5; RBBP-5; RBQ 3; RBQ3; retinoblastoma binding protein 5; Retinoblastoma-binding protein 5; Retinoblastoma-binding protein RBQ-3; SWD1; SWD1, Set1c WD40 repeat protein, homolog

Host Species:
Rabbit

Purification Method:
Antigen affinity chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
5929

Content And Storage:
-20°C, Avoid Freeze/Thaw Cycles

Form:
Liquid

Img

Fischer Scientific

50-199-3376

--


Antigen:
RBBP5

Classification:
Polyclonal

Concentration:
Lot-Specific

Formulation:
PBS with 30% glycerol and 0.035% sodium azide; pH 7.5

Gene Accession No.:
Q15291

Gene Symbols:
Rbbp5

Immunogen:
This antibody was raised against a peptide within the C-terminal region of human RBBP5.

Quantity:
10 μL

Primary or Secondary:
Primary

Target Species:
Human

Product Type:
Antibody

Isotype:
IgG

Applications:
ChIP Assay, ChIP sequencing (ChIP-seq), Western Blot

Clone:
__

Conjugate:
Unconjugated

Gene:
Rbbp5

Gene Alias:
4933411J24Rik; BOS_15527; C330016J05; RB binding protein 5, histone lysine methyltransferase complex subunit; RBBP 5; Rbbp5; RBBP-5; RBQ 3; RBQ3; retinoblastoma binding protein 5; Retinoblastoma-binding protein 5; Retinoblastoma-binding protein RBQ-3; SWD1; SWD1, Set1c WD40 repeat protein, homolog

Host Species:
Rabbit

Purification Method:
Antigen affinity chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
5929

Content And Storage:
-20°C, Avoid Freeze/Thaw Cycles

Form:
Liquid