50-199-3555

Histone H2A.XY142ph Polyclonal Antibody, Active Motif™

Manufacturer: Fischer Scientific

Select a Size

Pack Size SKU Availability Price
Each of 1 50-199-3555-Each-of-1 In Stock ₹ 50,480.40

50-199-3555 - Each of 1

₹ 50,480.40

In Stock

Quantity

1

Base Price: ₹ 50,480.40

GST (18%): ₹ 9,086.472

Total Price: ₹ 59,566.872

Antigen

Histone H2A.XY142ph

Classification

Polyclonal

Conjugate

Unconjugated

Gene

H2AX

Gene Alias

AW228881; gamma H2AX; gammaH2ax; H2A histone family member X; H2A histone family, member X; H2a.x; H2a/x; h2afx; H2AX; H2AX histone; Hist5-2ax; histone 5 protein 2ax; Histone H2A.X; Histone H2a/x; Histone H2AX; RGD1566119; similar to H2A histone family, member X; zgc:56329

Host Species

Rabbit

Purification Method

Antigen affinity chromatography

Regulatory Status

RUO

Gene ID (Entrez)

3014

Content And Storage

-20°C, Avoid Freeze/Thaw Cycles

Form

Liquid

Applications

Dot Blot, Western Blot

Concentration

Lot-Specific

Formulation

PBS with 30% glycerol and 0.035% sodium azide; pH 7.5

Gene Accession No.

P16104

Gene Symbols

H2AX

Immunogen

This antibody was raised against a peptide containing phospho-tyrosine 142 of human histone H2A.X.

Quantity

100 μL

Primary or Secondary

Primary

Target Species

Human

Product Type

Antibody

Isotype

IgG

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Description

  • Description Histone H2A.X (H2AX) is a member of the histone H2A family which is one of the four core histones making up the nucleosome core particle
  • In eukaryotes, DNA double strand breaks (DSBs) have been shown to trigger the phosphorylation of serine 139 at the carboxy terminus of histone H2AX resulting in gamma-H2AX
  • The phosphorylation of H2AX can be detected by Western blotting or immunofluorescence, revealing the frequency of DSBs
  • The phosphatidylinositol 3-kinases have been implicated in H2AX phosphorylation, but it is unclear if ATM is the primary H2AX kinase or if other members of the family such as DNA-PK and ATR contribute in a similar manner
  • Structurally, H2A.x contains 143 amino acid residues
  • Histone H2A.X is considered a basal histone, being synthesized in G1 as well as in S-phase, and its mRNA contains polyA addition motifs and a polyA tail along with the conserved stem-loop and U7 binding sequences involved in the processing and stability of replication type histone mRNAs
  • There are two forms of Histone H2A.X mRNA, one about 1600 bases long and contains polyA; the other about 575 bases long, lacking polyA
  • The short form behaves as a replication type histone mRNA, while the longer behaves as a basal type histone mRNA
  • Histone H2A.X maps to the 11q23.2-q23.3 region of the human chromosome
  • Histone H2A.x contributes to histone-formation and therefore the structure of DNA
  • Histone H2A variant H2A.x specifically regulates the interaction of MDC1 (mediator of DNA damage checkpoint protein 1), a DNA repair protein to the sites of DNA damage.

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Show Difference

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Fischer Scientific

50-199-3555

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Antigen:
Histone H2A.XY142ph

Classification:
Polyclonal

Conjugate:
Unconjugated

Gene:
H2AX

Gene Alias:
AW228881; gamma H2AX; gammaH2ax; H2A histone family member X; H2A histone family, member X; H2a.x; H2a/x; h2afx; H2AX; H2AX histone; Hist5-2ax; histone 5 protein 2ax; Histone H2A.X; Histone H2a/x; Histone H2AX; RGD1566119; similar to H2A histone family, member X; zgc:56329

Host Species:
Rabbit

Purification Method:
Antigen affinity chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
3014

Content And Storage:
-20°C, Avoid Freeze/Thaw Cycles

Form:
Liquid

Applications:
Dot Blot, Western Blot

Concentration:
Lot-Specific

Formulation:
PBS with 30% glycerol and 0.035% sodium azide; pH 7.5

Gene Accession No.:
P16104

Gene Symbols:
H2AX

Immunogen:
This antibody was raised against a peptide containing phospho-tyrosine 142 of human histone H2A.X.

Quantity:
100 μL

Primary or Secondary:
Primary

Target Species:
Human

Product Type:
Antibody

Isotype:
IgG

Img

Fischer Scientific

50-199-3556

--


Antigen:
Histone H2A.XY142ph

Classification:
Polyclonal

Conjugate:
Unconjugated

Gene:
H2AX

Gene Alias:
AW228881; gamma H2AX; gammaH2ax; H2A histone family member X; H2A histone family, member X; H2a.x; H2a/x; h2afx; H2AX; H2AX histone; Hist5-2ax; histone 5 protein 2ax; Histone H2A.X; Histone H2a/x; Histone H2AX; RGD1566119; similar to H2A histone family, member X; zgc:56329

Host Species:
Rabbit

Purification Method:
Antigen affinity chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
3014

Content And Storage:
-20°C, Avoid Freeze/Thaw Cycles

Form:
Liquid

Applications:
Dot Blot, Western Blot

Concentration:
Lot-Specific

Formulation:
PBS with 30% glycerol and 0.035% sodium azide; pH 7.5

Gene Accession No.:
P16104

Gene Symbols:
H2AX

Immunogen:
This antibody was raised against a peptide containing phospho-tyrosine 142 of human histone H2A.X.

Quantity:
10 μL

Primary or Secondary:
Primary

Target Species:
Human

Product Type:
Antibody

Isotype:
IgG

Img

Fischer Scientific

50-199-3557

--


Antigen:
CDKN2A

Classification:
Polyclonal

Conjugate:
Unconjugated

Gene:
CDKN2A

Gene Alias:
Alternative reading frame; ARF; ARF-INK4a; CDK4 inhibitor p16-INK4; CDK4I; CDKN2; CDKN2A; cdkn2a {ECO:0000312; cell cycle inhibitor; cell cycle negative regulator beta; cell cycle regulator; CMM2; cyclin dependent kinase inhibitor 2A; Cyclin dependent kinase inhibitor 2A (p16, inhibits CDK4); Cyclin-dependent kinase 4 inhibitor A; Cyclin-dependent kinase inhibitor 2A; cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4); cyclin-dependent kinase inhibitor 2A (p16, inhibits CDK4); cyclin-dependent kinase inhibitor 2a p16Ink4a; cyclin-dependent kinase inhibitor 2a p19Arf; cyclin-dependent kinase inhibitor 2A, isoform 1; cyclin-dependent kinase inhibitor 2A, isoform 2; cyclin-dependent kinase inhibitor 2A, isoform 3; cyclin-dependent kinase inhibitor 2A, isoforms 1/2; cyclin-dependent kinase inhibitor protein; EMBL:AAL76336.1, ECO:0000312; EMBL:AAL76338.1, ECO:0000312; HGNC:1787; inhibits CDK4; INK4; INK4A; Ink4a/Arf; INK4a-ARF; isoforms 1/2/3; mitochondrial smARF; MLM; MTS1; MTS-1; Multiple tumor suppressor 1; P14; P14 P16; p14ARF; p16; p16(INK4a); p16Cdkn2a; P16INK4; p16-INK4; P16ink4a; p16-INK4a; P19; P19 TP16; p19; p19ARF; Pctr1; RGD:2323}; TP16; Tumor suppressor ARF

Host Species:
Rabbit

Purification Method:
Antigen affinity chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
1029

Content And Storage:
-20°C, Avoid Freeze/Thaw Cycles

Form:
Liquid

Applications:
Immunoprecipitation, Western Blot

Concentration:
Lot-Specific

Formulation:
PBS with 30% glycerol and 0.035% sodium azide; pH 7.5

Gene Accession No.:
P42771, Q8N726

Gene Symbols:
CDKN2A

Immunogen:
This antibody was raised against a peptide within the N-terminal region of the p16/INk4a isoform of human CDkN2A.

Quantity:
100 μL

Primary or Secondary:
Primary

Target Species:
Human

Product Type:
Antibody

Isotype:
IgG

Img

Fischer Scientific

50-199-3558

--


Antigen:
CDKN2A

Classification:
Polyclonal

Conjugate:
Unconjugated

Gene:
CDKN2A

Gene Alias:
Alternative reading frame; ARF; ARF-INK4a; CDK4 inhibitor p16-INK4; CDK4I; CDKN2; CDKN2A; cdkn2a {ECO:0000312; cell cycle inhibitor; cell cycle negative regulator beta; cell cycle regulator; CMM2; cyclin dependent kinase inhibitor 2A; Cyclin dependent kinase inhibitor 2A (p16, inhibits CDK4); Cyclin-dependent kinase 4 inhibitor A; Cyclin-dependent kinase inhibitor 2A; cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4); cyclin-dependent kinase inhibitor 2A (p16, inhibits CDK4); cyclin-dependent kinase inhibitor 2a p16Ink4a; cyclin-dependent kinase inhibitor 2a p19Arf; cyclin-dependent kinase inhibitor 2A, isoform 1; cyclin-dependent kinase inhibitor 2A, isoform 2; cyclin-dependent kinase inhibitor 2A, isoform 3; cyclin-dependent kinase inhibitor 2A, isoforms 1/2; cyclin-dependent kinase inhibitor protein; EMBL:AAL76336.1, ECO:0000312; EMBL:AAL76338.1, ECO:0000312; HGNC:1787; inhibits CDK4; INK4; INK4A; Ink4a/Arf; INK4a-ARF; isoforms 1/2/3; mitochondrial smARF; MLM; MTS1; MTS-1; Multiple tumor suppressor 1; P14; P14 P16; p14ARF; p16; p16(INK4a); p16Cdkn2a; P16INK4; p16-INK4; P16ink4a; p16-INK4a; P19; P19 TP16; p19; p19ARF; Pctr1; RGD:2323}; TP16; Tumor suppressor ARF

Host Species:
Rabbit

Purification Method:
Antigen affinity chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
1029

Content And Storage:
-20°C, Avoid Freeze/Thaw Cycles

Form:
Liquid

Applications:
Immunoprecipitation, Western Blot

Concentration:
Lot-Specific

Formulation:
PBS with 30% glycerol and 0.035% sodium azide; pH 7.5

Gene Accession No.:
P42771, Q8N726

Gene Symbols:
CDKN2A

Immunogen:
This antibody was raised against a peptide within the N-terminal region of the p16/INk4a isoform of human CDkN2A.

Quantity:
10 μL

Primary or Secondary:
Primary

Target Species:
Human

Product Type:
Antibody

Isotype:
IgG