50-199-3774

Nanog Recombinant Mouse Monoclonal Antibody, AbFlex™, Active Motif™

Manufacturer: Fischer Scientific

Select a Size

Pack Size SKU Availability Price
Each of 1 50-199-3774-Each-of-1 In Stock ₹ 8,727.12

50-199-3774 - Each of 1

₹ 8,727.12

In Stock

Quantity

1

Base Price: ₹ 8,727.12

GST (18%): ₹ 1,570.882

Total Price: ₹ 10,298.002

Antigen

Nanog

Classification

Monoclonal

Conjugate

Unconjugated

Gene

NANOG

Gene Alias

2410002E02Rik; early embryo specific expression NK family; Early embryo specific expression NK-type homeobox protein; Ecat4; Enk; ES cell-associated protein 4; FLJ12581; HGNC:20857; hNanog; Homeobox protein NANOG; Homeobox transcription factor Nanog; homeobox transcription factor Nanog-delta 48; homeodomain transcription factor Nanog; NANOG; Nanog homeobox; Nanog homeodomain transcription factor

Host Species

Mouse

Purification Method

Protein A

Regulatory Status

RUO

Gene ID (Entrez)

71950

Content And Storage

-20°C, Avoid Freeze/Thaw Cycles

Form

Liquid

Applications

Western Blot

Concentration

1 mg/mL

Formulation

140mM HEPES, 32mM sodium acetate with 30% glycerol, 70mM NaCl and 0.035% sodium azide; pH 7.5

Gene Accession No.

Q80Z64

Gene Symbols

NANOG

Immunogen

This antibody was raised against a peptide comprising amino acids 2-25 of mouse Nanog.

Quantity

10 μg

Primary or Secondary

Primary

Target Species

Mouse

Product Type

Antibody

Isotype

IgG2a

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Description

  • NANOG (Nanog homeobox) is a divergent homeodomain protein that directs pluripotency and differentiation of undifferentiated embryonic stem cells
  • NANOG mRNA is present in pluripotent mouse and human cell lines, and absent from differentiated cells
  • Human NANOG protein shares 52% overall amino acid identity with the mouse protein, and 85% identity in the homeodomain
  • Human NANOG maps to gene locus 12p13.31, while the mouse NANOG maps to gene loci 6 F2
  • Murine embryonic NANOG expression is detected in the inner cell mass of the blastocyst
  • Research studies have shown that high levels of human NANOG expression in the undifferentiated N-Tera embryonal carcinoma cell line
  • Further, NANOG is a transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal
  • The role of NANOG in embryonic development suggested that it might be useful in the creation of stem cells that might be useful in cell replacement therapies in the treatment of several degenerative diseases
  • Artificial stem cells, termed induced pluripotent stem (iPS) cells, can be created by expressing POU5F1 (also known as Oct-4), another germline-specific transcription factor, and the transcription factors Sox2, Klf4 and Lin28 along with c-Myc in mouse fibroblasts
  • Experiments have demonstrated that iPS cells could be generated using expression plasmids expressing NANOG, Sox2, KlfF4 and c-Myc, eliminating the need for virus introduction, thereby addressing a safety concern for potential use of iPS cells in regenerative medicine
  • When overexpressed, NANOG promotes cells to enter into S phase and proliferation
  • Diseases associated with dysfunction in the NANOG protein include tetracarcinoma and germ cell/embryonal cancer.

Compare Similar Items

Show Difference

Img

Fischer Scientific

50-199-3774

--


Antigen:
Nanog

Classification:
Monoclonal

Conjugate:
Unconjugated

Gene:
NANOG

Gene Alias:
2410002E02Rik; early embryo specific expression NK family; Early embryo specific expression NK-type homeobox protein; Ecat4; Enk; ES cell-associated protein 4; FLJ12581; HGNC:20857; hNanog; Homeobox protein NANOG; Homeobox transcription factor Nanog; homeobox transcription factor Nanog-delta 48; homeodomain transcription factor Nanog; NANOG; Nanog homeobox; Nanog homeodomain transcription factor

Host Species:
Mouse

Purification Method:
Protein A

Regulatory Status:
RUO

Gene ID (Entrez):
71950

Content And Storage:
-20°C, Avoid Freeze/Thaw Cycles

Form:
Liquid

Applications:
Western Blot

Concentration:
1 mg/mL

Formulation:
140mM HEPES, 32mM sodium acetate with 30% glycerol, 70mM NaCl and 0.035% sodium azide; pH 7.5

Gene Accession No.:
Q80Z64

Gene Symbols:
NANOG

Immunogen:
This antibody was raised against a peptide comprising amino acids 2-25 of mouse Nanog.

Quantity:
10 μg

Primary or Secondary:
Primary

Target Species:
Mouse

Product Type:
Antibody

Isotype:
IgG2a

Img

Fischer Scientific

50-199-3775

--


Antigen:
Mili / PiwiL2

Classification:
Monoclonal

Conjugate:
Unconjugated

Gene:
Piwil2

Gene Alias:
80kDa PIWIL2 short isoform; Cancer/testis antigen 80; CT80; HILI; Mili; Miwi like; Miwi likw; piwi like homolog 2; piwi like RNA-mediated gene silencing 2; Piwil1l; Piwil2; PIWI-L2; piwil2-like protein; piwi-like 2; piwi-like homolog 2; Piwi-like protein 2; piwi-like RNA-mediated gene silencing 2; testicular tissue protein Li 141

Host Species:
Mouse

Purification Method:
Protein A

Regulatory Status:
RUO

Gene ID (Entrez):
57746

Content And Storage:
-20°C, Avoid Freeze/Thaw Cycles

Form:
Liquid

Applications:
Western Blot

Concentration:
1 mg/mL

Formulation:
140mM HEPES, 32mM sodium acetate with 30% glycerol, 70mM NaCl and 0.035% sodium azide; pH 7.5

Gene Accession No.:
Q8CDG1

Gene Symbols:
Piwil2

Immunogen:
This antibody was raised against full length mouse MILI/PIWIL2 (Miwi like/piwi-like 2) recombinant protein.

Quantity:
100 μg

Primary or Secondary:
Primary

Target Species:
Mouse

Product Type:
Antibody

Isotype:
IgG2a

Img

Fischer Scientific

50-199-3776

--


Antigen:
Mili / PiwiL2

Classification:
Monoclonal

Conjugate:
Unconjugated

Gene:
Piwil2

Gene Alias:
80kDa PIWIL2 short isoform; Cancer/testis antigen 80; CT80; HILI; Mili; Miwi like; Miwi likw; piwi like homolog 2; piwi like RNA-mediated gene silencing 2; Piwil1l; Piwil2; PIWI-L2; piwil2-like protein; piwi-like 2; piwi-like homolog 2; Piwi-like protein 2; piwi-like RNA-mediated gene silencing 2; testicular tissue protein Li 141

Host Species:
Mouse

Purification Method:
Protein A

Regulatory Status:
RUO

Gene ID (Entrez):
57746

Content And Storage:
-20°C, Avoid Freeze/Thaw Cycles

Form:
Liquid

Applications:
Western Blot

Concentration:
1 mg/mL

Formulation:
140mM HEPES, 32mM sodium acetate with 30% glycerol, 70mM NaCl and 0.035% sodium azide; pH 7.5

Gene Accession No.:
Q8CDG1

Gene Symbols:
Piwil2

Immunogen:
This antibody was raised against full length mouse MILI/PIWIL2 (Miwi like/piwi-like 2) recombinant protein.

Quantity:
10 μg

Primary or Secondary:
Primary

Target Species:
Mouse

Product Type:
Antibody

Isotype:
IgG2a

Img

Fischer Scientific

50-199-3779

--


Antigen:
Ubiquitin

Classification:
Monoclonal

Conjugate:
Unconjugated

Gene:
UBA52

Gene Alias:
60S ribosomal protein L40; BOS_7110; CEP52; D8Ertd21e; Gm1863; HUB L40; HUBCEP52; L40; Large ribosomal subunit protein eL40; MGC127041; RPL40; RPS27A; UBA52; Ubb; UBC; UBCEP2; Ubiquitin; Ubiquitin A-52 residue ribosomal protein fusion product 1; ubiquitin and ribosomal protein L40; ubiquitin carboxyl extension protein 52; ubiquitin/60S ribosomal fusion protein; ubiquitin-52 amino acid fusion protein; Ubiquitin-60S ribosomal protein L40; ubiquitin-CEP52

Host Species:
Mouse

Purification Method:
Protein A

Regulatory Status:
RUO

Gene ID (Entrez):
7311

Content And Storage:
-20°C, Avoid Freeze/Thaw Cycles

Form:
Liquid

Applications:
Dot Blot, Western Blot

Concentration:
1 mg/mL

Formulation:
140mM HEPES, 32mM sodium acetate with 30% glycerol, 70mM NaCl and 0.035% sodium azide; pH 7.5

Gene Accession No.:
P62987

Gene Symbols:
UBA52

Immunogen:
This antibody was raised against bovine ubiquitin.

Quantity:
100 μg

Primary or Secondary:
Primary

Target Species:
Human

Product Type:
Antibody

Isotype:
IgG2a