50-245-632

IL-17F Monoclonal Antibody (SHLR17), Functional Grade, eBioscience™, Invitrogen™

Manufacturer: Invitrogen

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Pack Size SKU Availability Price
Each 50-245-632-Each In Stock ₹ 15,627.53

50-245-632 - Each

₹ 15,627.53

In Stock

Quantity

1

Base Price: ₹ 15,627.53

GST (18%): ₹ 2,812.955

Total Price: ₹ 18,440.485

Antigen

IL-17F

Classification

Monoclonal

Concentration

1 mg/mL

Formulation

PBS with no preservative; pH 7.2

Gene Accession No.

Q96PD4

Gene Symbols

IL17F

Purification Method

Affinity chromatography

Regulatory Status

RUO

Gene ID (Entrez)

112744

Content And Storage

4° C

Form

Liquid

Applications

Functional Assay, Neutralization

Clone

SHLR17

Conjugate

Functional Grade

Gene

IL17F

Gene Alias

C87042; CANDF6; cytokine ML-1; IL17F; IL-17F; IL-24; ILN; Interleukin; interleukin 17F; Interleukin17F; interleukin-17F; interleukin-24; ML1; ML-1; mutant IL-17F

Host Species

Rat

Quantity

100 μg

Primary or Secondary

Primary

Target Species

Human

Product Type

Antibody

Isotype

IgG1 κ

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Description

  • Description: This SHLR17 monoclonal antibody reacts with human interleukin (IL)-17F
  • IL-17F is a homodimeric, 34 kDa member of the IL-17 family, which includes IL-17(A), B, C, D, E (IL-25)
  • Within this family, IL-17A and IL-17F are produced preferentially by T helper 17 (Th17) cells, with other members produced more widely
  • IL-17F and IL-17A have many overlapping functions, but knockout studies have shown each to have independent functions as well
  • In vitro cultured Th17 cells have been shown to express IL-17F and IL-17A homodimers and IL-17A/F heterodimers depending on the culture conditions and their differentiation state
  • A heterodimer of IL-17RA and IL-17RC has been shown to bind IL-17F, resulting in target cell-secretion of pro-inflammatory cytokines and chemokines, as well as neutrophil recruitment
  • This SHLR17 monoclonal antibody neutralizes the bioactivity of IL-17F homodimers without affecting IL-17A/F heterodimers
  • Applications Reported: This SHLR17 monoclonal antibody inhibits the activity of human IL-17F
  • Applications Tested: The ND50 of SHLR17, as measured by the inhibition of mouse IL-6 induction in NIH/3T3 cells, is 0.5-4 μg/mL in the presence of 1 μg/mL of Human IL-17F Recombit Protein
  • Neutralization dose will vary depending on assay method, cytokine concentration, and cell type
  • This antibody should be carefully titrated for optimal performance in the assay of interest
  • Endotoxin: Less than 0.001 ng/ug antibody as determined by the LAL assay
  • IL-17F (Interleukin 17F, CTLA-8)) is a cytokine belonging to the IL-17 family that is produced by inflammatory cells such as activated T cells, mast cells, and basophils
  • IL-17F is involved in allergic airway inflammation, and can induce several cytokines, chemokines, and adhesion molecules in bronchial epithelial cells, vein endothelial cells, fibroblasts, and eosinophils
  • IL-17F may be secreted as a homodimer, or a heterodimer with IL17A
  • It acts by binding to the type I receptor, IL-17R, aiding recruitment of monocytes and neutrophils at the site of inflammation by increasing chemokine production
  • IL-17F also stimulates induction of other pro-inflammatory cytokines TNF alpha, IL-1 beta, IL-6, and IL-8, and reports strongly suggest the involvement of IL-17 in several chronic inflammatory diseases such as rheumatoid arthritis, psoriasis and multiple sclerosis
  • TGF-beta (differentiation) and IL-23 (expansion) are required for induction and maintenance of Th17 (IL-17 producing) cells, which in turn induce the other pro-inflammatory cytokines
  • IL-17F is produced, and exists, as a homo-dimer, with homology to a herpes virus early protein, is one of the six members (IL-17A-F) of this cytokine family, and is well characterized and highly expressed by activated effector memory T cells
  • IL-17F has been found to inhibit the angiogenesis of endothelial cells and induce endothelial cells to produce IL2, TGFB1/TGFB, and monocyte chemoattractant protein-1.

Compare Similar Items

Show Difference

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Invitrogen

50-245-632

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Antigen:
IL-17F

Classification:
Monoclonal

Concentration:
1 mg/mL

Formulation:
PBS with no preservative; pH 7.2

Gene Accession No.:
Q96PD4

Gene Symbols:
IL17F

Purification Method:
Affinity chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
112744

Content And Storage:
4° C

Form:
Liquid

Applications:
Functional Assay, Neutralization

Clone:
SHLR17

Conjugate:
Functional Grade

Gene:
IL17F

Gene Alias:
C87042; CANDF6; cytokine ML-1; IL17F; IL-17F; IL-24; ILN; Interleukin; interleukin 17F; Interleukin17F; interleukin-17F; interleukin-24; ML1; ML-1; mutant IL-17F

Host Species:
Rat

Quantity:
100 μg

Primary or Secondary:
Primary

Target Species:
Human

Product Type:
Antibody

Isotype:
IgG1 κ

Img

eMolecules​

50-245-6320

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