OSMR Monoclonal Antibody (AN-V2), APC, eBioscience™, Invitrogen™

Description

• Description: This monoclonal AN-V2 antibody reacts with the human oncostatin M (OSM) receptor
• OSM, which belongs to the interleukin-6 cytokine family, is produced by T cells, activated monocytes, and dendritic cells
• In humans, OSM can bind two unique receptor complexes
• The type I OSM receptor is composed of the LIFR associated with gp130, and recognizes both LIF and OSM
• The type II OSM receptor, which consists of gp130 and the OSMR subunit, specifically binds the cytokine, leading to activation of the JAK/STAT signaling pathway
• Reports have also indicated a soluble form of the OSM receptor, which this antibody also recognizes
• The OSM receptor is expressed in the bone marrow, endothelium, liver, lung, and numerous tumor cell lines
• The AN-V2 monoclonal antibody recognizes the type II (beta) OSM receptor
• Applications Reported: This AN-V2 antibody has been reported for use in flow cytometric analysis
• Applications Tested: This AN-V2 antibody has been pre-titrated and tested by flow cytometric analysis of the A375 cell line
• This can be used at 5 μL (0.125 μg) per test
• A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL
• Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test
• Excitation: 633-647 nm; Emission: 660 nm; Laser: Red Laser
• Filtration: 0.2 μm post-manufacturing filtered
• Oncostatin M is a member of the IL6 family of cytokines
• Functional receptors for IL6 family cytokines are multisubunit complexes involving members of the hematopoietin receptor superfamily
• Many IL6 cytokines utilize gp130 as a common receptor subunit
• OSM binds to the gp130 receptor subunit and, in association with the leukemia inhibitory factor receptor, induces a proliferative response in permissive cells
• OSMR is an alternative subunit (for an OSM receptor complex (a heterodimer of gp130 and OSMR) that is activated by OSM but not by LIF.Oncostatin M is a member of the IL6 family of cytokines
• Functional receptors for IL6 family cytokines are multisubunit complexes involving members of the hematopoietin receptor superfamily
• Many IL6 cytokines utilize gp130 as a common receptor subunit
• OSM binds to the gp130 receptor subunit and, in association with the leukemia inhibitory factor receptor, induces a proliferative response in permissive cells
• OSMR is an alternative subunit (for an OSM receptor complex (a heterodimer of gp130 and OSMR) that is activated by OSM but not by LIF
• Publication Note: This RefSeq record includes a subset of the publications that are available for this gene
• Please see the Entrez Gene record to access additional publications.