50-246-012

Ki-67 Monoclonal Antibody (20Raj1), eFluor™ 450, eBioscience™, Invitrogen™

Manufacturer: Invitrogen

Select a Size

Pack Size SKU Availability Price
Each of 1 50-246-012-Each-of-1 In Stock ₹ 29,860.44

50-246-012 - Each of 1

₹ 29,860.44

In Stock

Quantity

1

Base Price: ₹ 29,860.44

GST (18%): ₹ 5,374.879

Total Price: ₹ 35,235.319

Antigen

Ki-67

Classification

Monoclonal

Concentration

5 μL/Test

Formulation

PBS with 0.2% BSA and 0.09% sodium azide; pH 7.2

Gene Accession No.

P46013

Gene Symbols

Mki67

Purification Method

Affinity chromatography

Regulatory Status

RUO

Gene ID (Entrez)

100686578, 4288

Content And Storage

4° C, store in dark, DO NOT FREEZE!

Form

Liquid

Applications

Flow Cytometry

Clone

20Raj1

Conjugate

eFluor 450

Gene

Mki67

Gene Alias

antigen identified by monoclonal antibody Ki 67; antigen identified by monoclonal antibody Ki-67; Antigen identified by monoclonal antibody Ki-67 homolog; Antigen KI-67; Antigen KI-67 homolog; antigen KI-67; proliferation marker protein Ki-67; antigen KI-67-like; cb31; D630048A14Rik; I79_022666; Ki67; Ki-67; KIA; LOW QUALITY PROTEIN: proliferation marker protein Ki-67; marker of proliferation Ki-67; MIB-; MIB-1; Mki67; PPP1R105; Proliferation marker protein Ki-67; proliferation-related Ki-67 antigen; protein phosphatase 1, regulatory subunit 105; RP11-380J17.2; sb:cb31; si:ch211-250b22.7; unnamed protein product; wu:fa11g09; wu:fb57a07; wu:fi14e05

Host Species

Mouse

Quantity

100 Tests

Primary or Secondary

Primary

Target Species

Canine, Human

Product Type

Antibody

Isotype

IgG1 κ

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Description

  • Description: The monoclonal antibody 20Raj1 recognizes the human Ki-67 protein
  • Two isoforms of Ki-67 exist, a 345 and 395 kDa form that are expressed in dividing cells
  • Ki-67 is expressed in all cell types and is detectable during active phases of the cell cycle (G1, S, G2, and mitosis) but is absent from resting cells (G0)
  • During interphase, Ki-67 expression is localized to the nucleus but redistributes to the chromosomes during mitosis and has specifically been found to associate with heterochromatin-bound proteins such as chromobox protein homolog 3 (CBX3)
  • In studies of tumor cells, Ki-67 expression has been used as a marker for determining the fraction of proliferating cells within a given population of tumor cells
  • This monoclonal antibody 20Raj1 recognizes canine Ki-67
  • Applications Reported: This 20Raj1 antibody has been reported for use in intracellular staining using the Foxp3 Staining Buffers followed by flow cytometric analysis
  • Applications Tested: This 20Raj1 antibody has been pre-titrated and tested by intracellular staining using Foxp3/Transcription Factor Buffers Set (cat
  • 00-5523) and protocol of normal human peripheral blood cells
  • Please see Best Protocols Section (Staining intracellular Antigens for Flow Cytometry) for staining protocol (refer to Protocol B: One-step protocol for intracellular (nuclear) proteins)
  • This can be used at 5 μL (0.06 μg) per test
  • Ki-67 is a nuclear protein that is expressed during various stages in the cell cycle, particularly during late G1, S, G2, and M phases
  • The protein has a forkhead associated domain (FHA) through which it associates with euchromatin at the perichromosomal layer, the centromeric heterochromatin, and the nucleolus
  • Ki-67 is shown to have a cell cycle dependent topographical distribution with perinucleolar expression at G1, expression in the nuclear matrix at G2, and expression on the chromosomes during M phase
  • Ki-67 is commonly used as a proliferation marker because it is not detected in G0 cells, but increases steadily from G1 through mitosis
  • Ki-67 antibodies are useful in establishing the cell growing fraction in neoplasms
  • In neoplastic tissues, the prognostic value is comparable to the tritiated thymidine-labelling index
  • The correlation between low Ki-67 index and histologically low-grade tumors is strong
  • Ki-67 is routinely used as a neuronal marker of cell cycling and proliferation.

Compare Similar Items

Show Difference

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Invitrogen

50-246-012

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Antigen:
Ki-67

Classification:
Monoclonal

Concentration:
5 μL/Test

Formulation:
PBS with 0.2% BSA and 0.09% sodium azide; pH 7.2

Gene Accession No.:
P46013

Gene Symbols:
Mki67

Purification Method:
Affinity chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
100686578, 4288

Content And Storage:
4° C, store in dark, DO NOT FREEZE!

Form:
Liquid

Applications:
Flow Cytometry

Clone:
20Raj1

Conjugate:
eFluor 450

Gene:
Mki67

Gene Alias:
antigen identified by monoclonal antibody Ki 67; antigen identified by monoclonal antibody Ki-67; Antigen identified by monoclonal antibody Ki-67 homolog; Antigen KI-67; Antigen KI-67 homolog; antigen KI-67; proliferation marker protein Ki-67; antigen KI-67-like; cb31; D630048A14Rik; I79_022666; Ki67; Ki-67; KIA; LOW QUALITY PROTEIN: proliferation marker protein Ki-67; marker of proliferation Ki-67; MIB-; MIB-1; Mki67; PPP1R105; Proliferation marker protein Ki-67; proliferation-related Ki-67 antigen; protein phosphatase 1, regulatory subunit 105; RP11-380J17.2; sb:cb31; si:ch211-250b22.7; unnamed protein product; wu:fa11g09; wu:fb57a07; wu:fi14e05

Host Species:
Mouse

Quantity:
100 Tests

Primary or Secondary:
Primary

Target Species:
Canine, Human

Product Type:
Antibody

Isotype:
IgG1 κ

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eMolecules​

50-246-0120

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