CD160 Monoclonal Antibody (BY55), Alexa Fluor™ 488, eBioscience™, Invitrogen™

Description

• Description: This BY55 monoclonal antibody reacts with human CD160, a member of the immunoglobulin superfamily expressed on natural killer cells, natural killer T cells, activated and/or memory CD4 and CD8 T cells, gamma/delta T cells, and intraepithelial cells
• CD160 has been reported to bind herpes virus entry mediator (HVEM) in a complex with LIGHT and BTLA to deliver an inhibitory signal to CD4 T cells that abrogates proliferation and cytokine production
• Three alternative splice variants of CD160 have also been identified in natural killer cells
• Applications Reported: This BY55 antibody has been reported for use in flow cytometric analysis
• Applications Tested: This BY55 antibody has been pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells
• This can be used at 5 μL (0.25 μg) per test
• A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL
• Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test
• Excitation: 488 nm; Emission: 519 nm; Laser: Blue Laser
• Filtration: 0.2 μm post-manufacturing filtered
• CD160 is a receptor showing broad specificity for both classical and non-classical MHC class I molecules
• CD160 is expressed at the cell surface as a tightly disulfide-linked multimer
• It is involved in cell proliferation, cell surface receptor signaling pathways, cellular defense response, and regulation of immune response.