67-575-742

VSIG4 Monoclonal Antibody (JAV4), Super Bright™ 702, eBioscience™, Invitrogen™

Manufacturer: eBioscience

Select a Size

Pack Size SKU Availability Price
Each of 1 67-575-742-Each-of-1 In Stock ₹ 33,625.08

67-575-742 - Each of 1

₹ 33,625.08

In Stock

Quantity

1

Base Price: ₹ 33,625.08

GST (18%): ₹ 6,052.514

Total Price: ₹ 39,677.594

Antigen

VSIG4

Classification

Monoclonal

Concentration

5 μL/Test

Formulation

PBS with BSA and 0.09% sodium azide; pH 7.2

Gene Accession No.

Q9Y279

Gene Symbols

VSIG4

Purification Method

Affinity chromatography

Regulatory Status

RUO

Gene ID (Entrez)

11326

Content And Storage

4° C, store in dark, DO NOT FREEZE!

Form

Liquid

Applications

Flow Cytometry

Clone

JAV4

Conjugate

Super Bright 702

Gene

VSIG4

Gene Alias

A530061A11; BC025105; complement receptor of the immunoglobulin superfamily; CRIg; Ig superfamily protein; MGC137243 protein; protein Z39Ig; UNQ317/PRO362; V-set and immunoglobulin domain containing 4; V-set and immunoglobulin domain-containing protein 4; VSIG4; Z39IG

Host Species

Mouse

Quantity

100 Tests

Primary or Secondary

Primary

Target Species

Human

Product Type

Antibody

Isotype

IgG2a κ

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Description

  • Description: This JAV4 monoclonal antibody recognizes human V-Set and Immunoglobulin domain containing 4 (VSIG4), also known as Complement Receptor of the Immunoglobulin superfamily (CRIg) or Z39Ig
  • There are two variants of human VSIG4 that result from alternative splicing
  • Isoform 1 is longer and more prevalent than isoform 2, and this JAV4 antibody recognizes both
  • VSIG4 is a type I transmembrane glycoprotein structurally related to the B7 family of immune regulatory proteins
  • It contains one complete V-type Ig domain and one truncated C-type Ig domain
  • VSIG4 is exclusively expressed on tissue resident and tumor infiltrating macrophages
  • It has been shown to bind complement components C3b and iC3b
  • This binding inhibits the alternative complement pathway and facilitates phagocytosis of complement-opsonized pathogens
  • VSIG4 has also been reported to suppress T cell activation, proliferation and IL-2 production thereby playing a role in the maintece of peripheral T cell tolerance and suppression of established inflammation
  • Expression of VSIG4 on tumor-infiltrating macrophages suggests its role in immune evasion
  • Pro-inflammatory stimuli such as TNF and LPS have been reported to down-regulate the expression of VSIG4
  • The JAV4 antibody will recognize VSIG4 on cells that have been formaldehyde-fixed and permeabilized
  • This antibody does not cross-react with mouse or rat VSIG4
  • Applications Reported: This JAV4 antibody has been reported for use in flow cytometric analysis
  • T cell activation by APCs is positively and negatively regulated by members of the B7 family
  • VSIG4 is a strong negative regulator of murine and human T cell proliferation and IL-2 production.

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eBioscience

67-575-742

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Antigen:
VSIG4

Classification:
Monoclonal

Concentration:
5 μL/Test

Formulation:
PBS with BSA and 0.09% sodium azide; pH 7.2

Gene Accession No.:
Q9Y279

Gene Symbols:
VSIG4

Purification Method:
Affinity chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
11326

Content And Storage:
4° C, store in dark, DO NOT FREEZE!

Form:
Liquid

Applications:
Flow Cytometry

Clone:
JAV4

Conjugate:
Super Bright 702

Gene:
VSIG4

Gene Alias:
A530061A11; BC025105; complement receptor of the immunoglobulin superfamily; CRIg; Ig superfamily protein; MGC137243 protein; protein Z39Ig; UNQ317/PRO362; V-set and immunoglobulin domain containing 4; V-set and immunoglobulin domain-containing protein 4; VSIG4; Z39IG

Host Species:
Mouse

Quantity:
100 Tests

Primary or Secondary:
Primary

Target Species:
Human

Product Type:
Antibody

Isotype:
IgG2a κ

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Antigen:
CD366 (TIM3)

Classification:
Monoclonal

Concentration:
0.2 mg/mL

Formulation:
PBS with BSA and 0.09% sodium azide; pH 7.2

Gene Accession No.:
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Gene Symbols:
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Purification Method:
Affinity chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
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Content And Storage:
4° C, store in dark, DO NOT FREEZE!

Form:
Liquid

Applications:
Flow Cytometry

Clone:
RMT3-23

Conjugate:
Super Bright 702

Gene:
Havcr2

Gene Alias:
CD366; FLJ14428; Havcr2; HAVcr-2; Hepatitis A virus cellular receptor 2; hepatitis A virus cellular receptor 2 homolog; kidney injury molecule-3; KIM-3; sCD366; soluble CD366; soluble TIM 3; T cell immunoglobulin mucin 3; T cell immunoglobulin mucin-3; T-cell immunoglobulin and mucin domain containing 3; T-cell immunoglobulin and mucin domain-containing protein 3; T-cell immunoglobulin mucin family member 3; T-cell immunoglobulin mucin receptor 3; T-cell membrane protein 3; Tim3; TIM-3; TIMD3; TIMD-3

Host Species:
Rat

Quantity:
100 μg

Primary or Secondary:
Primary

Target Species:
Mouse

Product Type:
Antibody

Isotype:
IgG2a κ

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CD357 (AITR/GITR)

Classification:
Monoclonal

Concentration:
0.2 mg/mL

Formulation:
PBS with BSA and 0.09% sodium azide; pH 7.2

Gene Accession No.:
O35714

Gene Symbols:
Tnfrsf18

Purification Method:
Affinity chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
21936

Content And Storage:
4° C, store in dark, DO NOT FREEZE!

Form:
Liquid

Applications:
Flow Cytometry

Clone:
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Conjugate:
Super Bright 702

Gene:
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Gene Alias:
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Host Species:
Rat

Quantity:
100μg

Primary or Secondary:
Primary

Target Species:
Mouse

Product Type:
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Isotype:
IgG2b κ

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TER-119

Classification:
Monoclonal

Concentration:
0.2 mg/mL

Formulation:
PBS with BSA and 0.09% sodium azide; pH 7.2

Gene Accession No.:
0

Gene Symbols:
Ly76

Purification Method:
Affinity chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
104231

Content And Storage:
4° C, store in dark, DO NOT FREEZE!

Form:
Liquid

Applications:
Flow Cytometry

Clone:
TER-119

Conjugate:
Super Bright 702

Gene:
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Gene Alias:
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Host Species:
Rat

Quantity:
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Primary or Secondary:
Primary

Target Species:
Mouse

Product Type:
Antibody

Isotype:
IgG2b κ