7069451

Ki-67 Monoclonal Antibody (SolA15), eBioscience™, Invitrogen™

Rat Monoclonal Antibody

Manufacturer: Fischer Scientific

The price for this product is unavailable. Please request a quote

Antigen

Ki-67

Concentration

0.5 mg/mL

Classification

Monoclonal

Form

Liquid

Regulatory Status

RUO

Formulation

PBS with 0.09% sodium azide; pH 7.2

Gene Alias

antigen identified by monoclonal antibody Ki 67; antigen identified by monoclonal antibody Ki-67; Antigen identified by monoclonal antibody Ki-67 homolog; Antigen KI-67; Antigen KI-67 homolog; antigen KI-67; proliferation marker protein Ki-67; antigen KI-67-like; cb31; D630048A14Rik; I79_022666; Ki67; Ki-67; KIA; LOW QUALITY PROTEIN: proliferation marker protein Ki-67; marker of proliferation Ki-67; MIB-; MIB-1; Mki67; PPP1R105; Proliferation marker protein Ki-67; proliferation-related Ki-67 antigen; protein phosphatase 1, regulatory subunit 105; RP11-380J17.2; sb:cb31; si:ch211-250b22.7; unnamed protein product; wu:fa11g09; wu:fb57a07; wu:fi14e05

Gene Symbols

Mki67

Primary or Secondary

Primary

Content And Storage

4° C

Gene

Mki67

Clone

SolA15

Applications

Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin)

Conjugate

Unconjugated

Host Species

Rat

Target Species

Canine, Cynomolgus Monkey, Human, Mouse, Non-human Primate, Rat

Gene Accession No.

E9PVX6, P46013

Gene ID (Entrez)

100686578, 102135895, 17345, 291234, 4288

Isotype

IgG2a κ

Purification Method

Affinity chromatography

Product Type

Antibody

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Description

  • Description: The monoclonal antibody SolA15 recognizes mouse and rat Ki-67, a 300 kDa nuclear protein
  • Ki-67 is present during all active phases of the cell cycle (G1, S, G2, and mitosis), but is absent from resting cells (G0)
  • Ki-67 is detected within the nucleus during interphase but redistributes to the chromosomes during mitosis
  • Ki-67 is used as a marker for determining the growth fraction of a given population of cells
  • In studies of tumor cells, the Ki-67 labeling index refers to the number of Ki-67 positive cells within the population and this is used to predict outcome of particular cancer types
  • Ki-67 has been shown to interact with the DNA-bound protein chromobox protein homolog 3 (CBX3) (heterochromatin)
  • The SolA15 antibody also recognizes human, non-human primate and canine Ki-67
  • Applications Reported: This SolA15 antibody has been reported for use in immunohistochemical staining of formalin-fixed paraffin embedded (FFPE) tissue sections and frozen (paraformaldehyde fixed) sections and immunocytochemistry (ICC)
  • Applications Tested: This SolA15 antibody has been tested by immunohistochemistry on formalin-fixed paraffin embedded mouse skin with high or low pH antigen retrieval and immunocytochemistry on fixed and permeabilized C2C12 cells at less than or equal to 5 μg/mL
  • It is recommended that this antibody be carefully titrated for optimal performance in the assay of interest
  • Purity: Greater than 90%, as determined by SDS-PAGE
  • Ki-67 is a nuclear protein that is expressed during various stages in the cell cycle, particularly during late G1, S, G2, and M phases
  • The protein has a forkhead associated domain (FHA) through which it associates with euchromatin at the perichromosomal layer, the centromeric heterochromatin, and the nucleolus
  • Ki-67 is shown to have a cell cycle dependent topographical distribution with perinucleolar expression at G1, expression in the nuclear matrix at G2, and expression on the chromosomes during M phase
  • Ki-67 is commonly used as a proliferation marker because it is not detected in G0 cells, but increases steadily from G1 through mitosis
  • Ki-67 antibodies are useful in establishing the cell growing fraction in neoplasms
  • In neoplastic tissues, the prognostic value is comparable to the tritiated thymidine-labelling index
  • The correlation between low Ki-67 index and histologically low-grade tumors is strong
  • Ki-67 is routinely used as a neuronal marker of cell cycling and proliferation.

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Fischer Scientific

7069451

Rat Monoclonal Antibody...


Antigen:
Ki-67

Concentration:
0.5 mg/mL

Classification:
Monoclonal

Form:
Liquid

Regulatory Status:
RUO

Formulation:
PBS with 0.09% sodium azide; pH 7.2

Gene Alias:
antigen identified by monoclonal antibody Ki 67; antigen identified by monoclonal antibody Ki-67; Antigen identified by monoclonal antibody Ki-67 homolog; Antigen KI-67; Antigen KI-67 homolog; antigen KI-67; proliferation marker protein Ki-67; antigen KI-67-like; cb31; D630048A14Rik; I79_022666; Ki67; Ki-67; KIA; LOW QUALITY PROTEIN: proliferation marker protein Ki-67; marker of proliferation Ki-67; MIB-; MIB-1; Mki67; PPP1R105; Proliferation marker protein Ki-67; proliferation-related Ki-67 antigen; protein phosphatase 1, regulatory subunit 105; RP11-380J17.2; sb:cb31; si:ch211-250b22.7; unnamed protein product; wu:fa11g09; wu:fb57a07; wu:fi14e05

Gene Symbols:
Mki67

Primary or Secondary:
Primary

Content And Storage:
4° C

Gene:
Mki67

Clone:
SolA15

Applications:
Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin)

Conjugate:
Unconjugated

Host Species:
Rat

Target Species:
Canine, Cynomolgus Monkey, Human, Mouse, Non-human Primate, Rat

Gene Accession No.:
E9PVX6, P46013

Gene ID (Entrez):
100686578, 102135895, 17345, 291234, 4288

Isotype:
IgG2a κ

Purification Method:
Affinity chromatography

Product Type:
Antibody

Img

Fischer Scientific

7069452

Mouse Monoclonal Antibody...


Antigen:
Ki-67

Concentration:
0.5 mg/mL

Classification:
Monoclonal

Form:
Liquid

Regulatory Status:
RUO

Formulation:
PBS with 0.09% sodium azide; pH 7.2

Gene Alias:
antigen identified by monoclonal antibody Ki 67; antigen identified by monoclonal antibody Ki-67; Antigen identified by monoclonal antibody Ki-67 homolog; Antigen KI-67; Antigen KI-67 homolog; antigen KI-67; proliferation marker protein Ki-67; antigen KI-67-like; cb31; D630048A14Rik; I79_022666; Ki67; Ki-67; KIA; LOW QUALITY PROTEIN: proliferation marker protein Ki-67; marker of proliferation Ki-67; MIB-; MIB-1; Mki67; PPP1R105; Proliferation marker protein Ki-67; proliferation-related Ki-67 antigen; protein phosphatase 1, regulatory subunit 105; RP11-380J17.2; sb:cb31; si:ch211-250b22.7; unnamed protein product; wu:fa11g09; wu:fb57a07; wu:fi14e05

Gene Symbols:
Mki67

Primary or Secondary:
Primary

Content And Storage:
4° C

Gene:
Mki67

Clone:
20Raj1

Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin)

Conjugate:
Unconjugated

Host Species:
Mouse

Target Species:
Canine, Human

Gene Accession No.:
P46013

Gene ID (Entrez):
100686578, 4288

Isotype:
IgG1 κ

Purification Method:
Affinity chromatography

Product Type:
Antibody

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7069454

Mouse Monoclonal Antibody...


Antigen:
Ea52-68 peptide bound to I-Ab

Concentration:
0.5 mg/mL

Classification:
Monoclonal

Form:
Liquid

Regulatory Status:
RUO

Formulation:
PBS with 0.09% sodium azide; pH 7.2

Gene Alias:
Abeta; AI845868; H-2 class II histocompatibility antigen, A beta chain; H-2Ab; H2-Ab; H2-Ab1; H2Eb; H-2Eb; H2-iabeta; histocompatibility 2, class II antigen A, beta 1; Ia2; Ia-2; Ia4; Ia-4; IAb; I-Abeta; major histocompatibility complex class II beta chain; MGC163794; MGC163796; MHC class II antigen A beta; MHC class II H2-IA-beta-psi; response to metastatic cancers 1; Rmcs1

Gene Symbols:
H2-Ab1

Primary or Secondary:
Primary

Content And Storage:
4° C

Gene:
H2-Ab1

Clone:
eBioY-Ae (YAe, Y-Ae), Y-Ae)

Applications:
Flow Cytometry

Conjugate:
Unconjugated

Host Species:
Mouse

Target Species:
Mouse

Gene Accession No.:
P01921, P06342, P06343, P06344, P06345, P06346, P14483

Gene ID (Entrez):
14961

Isotype:
IgG2b

Purification Method:
Affinity chromatography

Product Type:
Antibody

Img

Fischer Scientific

7069454

Mouse Monoclonal Antibody...


Antigen:
Ea52-68 peptide bound to I-Ab

Concentration:
0.5 mg/mL

Classification:
Monoclonal

Form:
Liquid

Regulatory Status:
RUO

Formulation:
PBS with 0.09% sodium azide; pH 7.2

Gene Alias:
Abeta; AI845868; H-2 class II histocompatibility antigen, A beta chain; H-2Ab; H2-Ab; H2-Ab1; H2Eb; H-2Eb; H2-iabeta; histocompatibility 2, class II antigen A, beta 1; Ia2; Ia-2; Ia4; Ia-4; IAb; I-Abeta; major histocompatibility complex class II beta chain; MGC163794; MGC163796; MHC class II antigen A beta; MHC class II H2-IA-beta-psi; response to metastatic cancers 1; Rmcs1

Gene Symbols:
H2-Ab1

Primary or Secondary:
Primary

Content And Storage:
4° C

Gene:
H2-Ab1

Clone:
eBioY-Ae (YAe, Y-Ae), Y-Ae)

Applications:
Flow Cytometry

Conjugate:
Unconjugated

Host Species:
Mouse

Target Species:
Mouse

Gene Accession No.:
P01921, P06342, P06343, P06344, P06345, P06346, P14483

Gene ID (Entrez):
14961

Isotype:
IgG2b

Purification Method:
Affinity chromatography

Product Type:
Antibody