7069534
NFkB p65 Polyclonal Antibody, eBioscience™, Invitrogen™
Rabbit Polyclonal Antibody
Manufacturer: Fischer Scientific
The price for this product is unavailable. Please request a quote
Antigen
NFkB p65
Applications
ChIP Assay, Immunocytochemistry, Immunohistochemistry, Immunoprecipitation, Western Blot
Conjugate
Unconjugated
Host Species
Rabbit
Target Species
Human, Mouse, Rat
Gene Accession No.
Q04206, Q04207
Gene ID (Entrez)
19697, 309165, 5970
Isotype
IgG
Purification Method
Affinity chromatography
Product Type
Antibody
Concentration
0.2 mg/mL
Classification
Polyclonal
Form
Liquid
Regulatory Status
RUO
Formulation
PBS with 0.02% gelatin, BSA and 0.1% sodium azide
Gene Alias
avian reticuloendotheliosis viral (v-rel) oncogene homolog A; EBP-1; I79_021812; MGC131774; NF KB; NFkappaB p65; nf-kappa-b p65; NF-kappa-B p65delta3; NF-kappa-B transcription factor p65; NF-kappaB transcription factor p65 subunit; NFkB; NF-kB p65 subunit; nfkb rela; NFKB1; nfkb3; NFkB-p50; nuclear factor; nuclear factor kappa b; nuclear factor kappa B subunit p65; nuclear factor NF-kappa-B p65 subunit; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3; p65; p65 NF kappaB; p65 NF-kappa B; p65 NFkB; P65 transcription factor; putative transcription factor p65 homolog; REL A; rel1; rela; RELA proto-oncogene, NF-kB subunit; rela.L; rela-a; Transcription factor p65; v-rel avian reticuloendotheliosis viral oncogene homolog A; v-rel avian reticuloendotheliosis viral oncogene homolog A L homeolog; v-rel reticuloendotheliosis viral oncogene homolog A; v-rel reticuloendotheliosis viral oncogene homolog A (avian); v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65; XELAEV_18022301mg; Xrel1; xrela
Gene Symbols
RELA
Primary or Secondary
Primary
Content And Storage
4° C
Gene
RELA
Related Products
Description
- Description: The polyclonal antibody reacts with mouse, rat, and human NFkB p65; the antibody was raised against a peptide mapping to the carboxy terminus of human NFkB p65
- Members of the rel/NFkB family of transcription factors are involved in the regulation of cellular responses, such as growth, development, and the inflammatory response
- They share a structural motif known as the rel homology region (RHR), the C-terminal one third of which mediates protein dimerization (2, 6, 8)
- Complexes of p50 (NF-kB1) or p52 (NF-kB2) are generated through the processing of p105 and p100 precursors, respectively
- These are usually associated with members of the Rel family (p65, c-Rel, Rel B)
- The homo- and heterodimer formed through combinations of NFkB/Rel proteins bind distinct kB sites to regulate the transcription of different genes (7, 9)
- In resting cells, NFkB is retained in the cytoplasm bound to inhibitory proteins of the IkB family
- Degradation of IkB proteins occurs with cell activation, via of variety of signals, including inflammatory cytokines and bacterial lipopolysaccharides (LPS) as well as oxidative and fluid mechanical stress
- This results in nuclear translocation of NFkB and the transcriptional gene activation of proinflammatory genes (1, 9)
- It has been suggested that NFkB plays a role in the development of numerous pathological states
- Nuclear factor kB p65 (NF-kB p65) is encoded by the RELA gene and is present on chromosome 11 in humans
- NF-kB P65 is also known as RelA (v-rel avian reticuloendotheliosis viral oncogene homolog A) and belongs to the Rel family of proteins
- It is one of the two subunits of NF-kB (Nuclear factor kappa-light-chain-enhancer of activated B cells) that heterodimerizes with the other subunits p50 or p52
- However, binding of TNF alpha to its cognate receptor phosphorylates IKK which in turn phosphorylates I kB allowing proteasomal degradation of I kB
- It specifically plays a key role in transcription of immunoglobulin k (kappa) gene in mature B-lymphoid cells.
Compare Similar Items
Show Difference
Antigen: NFkB p65
Applications: ChIP Assay, Immunocytochemistry, Immunohistochemistry, Immunoprecipitation, Western Blot
Conjugate: Unconjugated
Host Species: Rabbit
Target Species: Human, Mouse, Rat
Gene Accession No.: Q04206, Q04207
Gene ID (Entrez): 19697, 309165, 5970
Isotype: IgG
Purification Method: Affinity chromatography
Product Type: Antibody
Concentration: 0.2 mg/mL
Classification: Polyclonal
Form: Liquid
Regulatory Status: RUO
Formulation: PBS with 0.02% gelatin, BSA and 0.1% sodium azide
Gene Alias: avian reticuloendotheliosis viral (v-rel) oncogene homolog A; EBP-1; I79_021812; MGC131774; NF KB; NFkappaB p65; nf-kappa-b p65; NF-kappa-B p65delta3; NF-kappa-B transcription factor p65; NF-kappaB transcription factor p65 subunit; NFkB; NF-kB p65 subunit; nfkb rela; NFKB1; nfkb3; NFkB-p50; nuclear factor; nuclear factor kappa b; nuclear factor kappa B subunit p65; nuclear factor NF-kappa-B p65 subunit; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3; p65; p65 NF kappaB; p65 NF-kappa B; p65 NFkB; P65 transcription factor; putative transcription factor p65 homolog; REL A; rel1; rela; RELA proto-oncogene, NF-kB subunit; rela.L; rela-a; Transcription factor p65; v-rel avian reticuloendotheliosis viral oncogene homolog A; v-rel avian reticuloendotheliosis viral oncogene homolog A L homeolog; v-rel reticuloendotheliosis viral oncogene homolog A; v-rel reticuloendotheliosis viral oncogene homolog A (avian); v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65; XELAEV_18022301mg; Xrel1; xrela
Gene Symbols: RELA
Primary or Secondary: Primary
Content And Storage: 4° C
Gene: RELA
Antigen:
NFkB p65
Applications:
ChIP Assay, Immunocytochemistry, Immunohistochemistry, Immunoprecipitation, Western Blot
Conjugate:
Unconjugated
Host Species:
Rabbit
Target Species:
Human, Mouse, Rat
Gene Accession No.:
Q04206, Q04207
Gene ID (Entrez):
19697, 309165, 5970
Isotype:
IgG
Purification Method:
Affinity chromatography
Product Type:
Antibody
Concentration:
0.2 mg/mL
Classification:
Polyclonal
Form:
Liquid
Regulatory Status:
RUO
Formulation:
PBS with 0.02% gelatin, BSA and 0.1% sodium azide
Gene Alias:
avian reticuloendotheliosis viral (v-rel) oncogene homolog A; EBP-1; I79_021812; MGC131774; NF KB; NFkappaB p65; nf-kappa-b p65; NF-kappa-B p65delta3; NF-kappa-B transcription factor p65; NF-kappaB transcription factor p65 subunit; NFkB; NF-kB p65 subunit; nfkb rela; NFKB1; nfkb3; NFkB-p50; nuclear factor; nuclear factor kappa b; nuclear factor kappa B subunit p65; nuclear factor NF-kappa-B p65 subunit; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3; p65; p65 NF kappaB; p65 NF-kappa B; p65 NFkB; P65 transcription factor; putative transcription factor p65 homolog; REL A; rel1; rela; RELA proto-oncogene, NF-kB subunit; rela.L; rela-a; Transcription factor p65; v-rel avian reticuloendotheliosis viral oncogene homolog A; v-rel avian reticuloendotheliosis viral oncogene homolog A L homeolog; v-rel reticuloendotheliosis viral oncogene homolog A; v-rel reticuloendotheliosis viral oncogene homolog A (avian); v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65; XELAEV_18022301mg; Xrel1; xrela
Gene Symbols:
RELA
Primary or Secondary:
Primary
Content And Storage:
4° C
Gene:
RELA
Antigen: c-Myc
Applications: ChIP Assay, Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Conjugate: Unconjugated
Host Species: Mouse
Target Species: Human
Gene Accession No.: P01106
Gene ID (Entrez): 4609
Isotype: IgG1
Purification Method: Affinity chromatography
Product Type: Antibody
Concentration: 0.5 mg/mL
Classification: Monoclonal
Form: Liquid
Regulatory Status: RUO
Formulation: PBS with 0.09% sodium azide; pH 7.2
Gene Alias: AU016757; Avian myelocytomatosis viral (v-myc) oncogene homolog; avian myelocytomatosis viral oncogene homolog; bHLHe39; c Myc; class E basic helix-loop-helix protein 39; cmyc; c-Myc; c-myc epitope tag; c-myc proto-oncogene; mMyc; MRTL; Myc; Myc protein; Myc proto-oncogene protein; MYC proto-oncogene, bHLH transcription factor; Myc2; MYCC; myc-related translation/localization regulatory factor; myelocytomatosis oncogene; myelocytomatosis viral oncogene homolog; Niard; Nird; Proto-oncogene c-Myc; RNCMYC; Transcription factor p64; v-myc avian myelocytomatosis viral oncogene homolog; v-myc myelocytomatosis viral oncogene homolog; v-myc myelocytomatosis viral oncogene-like protein
Gene Symbols: MYC
Primary or Secondary: Primary
Content And Storage: 4° C
Gene: MYC
Antigen:
c-Myc
Applications:
ChIP Assay, Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Conjugate:
Unconjugated
Host Species:
Mouse
Target Species:
Human
Gene Accession No.:
P01106
Gene ID (Entrez):
4609
Isotype:
IgG1
Purification Method:
Affinity chromatography
Product Type:
Antibody
Concentration:
0.5 mg/mL
Classification:
Monoclonal
Form:
Liquid
Regulatory Status:
RUO
Formulation:
PBS with 0.09% sodium azide; pH 7.2
Gene Alias:
AU016757; Avian myelocytomatosis viral (v-myc) oncogene homolog; avian myelocytomatosis viral oncogene homolog; bHLHe39; c Myc; class E basic helix-loop-helix protein 39; cmyc; c-Myc; c-myc epitope tag; c-myc proto-oncogene; mMyc; MRTL; Myc; Myc protein; Myc proto-oncogene protein; MYC proto-oncogene, bHLH transcription factor; Myc2; MYCC; myc-related translation/localization regulatory factor; myelocytomatosis oncogene; myelocytomatosis viral oncogene homolog; Niard; Nird; Proto-oncogene c-Myc; RNCMYC; Transcription factor p64; v-myc avian myelocytomatosis viral oncogene homolog; v-myc myelocytomatosis viral oncogene homolog; v-myc myelocytomatosis viral oncogene-like protein
Gene Symbols:
MYC
Primary or Secondary:
Primary
Content And Storage:
4° C
Gene:
MYC
Antigen: V5 Tag
Applications: Immunocytochemistry, Western Blot
Conjugate: Unconjugated
Host Species: Mouse
Target Species: Tag
Gene Accession No.: __
Gene ID (Entrez): __
Isotype: IgG2b κ
Purification Method: Affinity chromatography
Product Type: Antibody
Concentration: 0.5 mg/mL
Classification: Monoclonal
Form: Liquid
Regulatory Status: RUO
Formulation: PBS with 0.09% sodium azide; pH 7.2
Gene Alias: simian virus 5 antibody; SPV5gp2; sv5; V5; v-5; V5 Epitope Tag
Gene Symbols: __
Primary or Secondary: Primary
Content And Storage: 4° C
Gene: __
Antigen:
V5 Tag
Applications:
Immunocytochemistry, Western Blot
Conjugate:
Unconjugated
Host Species:
Mouse
Target Species:
Tag
Gene Accession No.:
__
Gene ID (Entrez):
__
Isotype:
IgG2b κ
Purification Method:
Affinity chromatography
Product Type:
Antibody
Concentration:
0.5 mg/mL
Classification:
Monoclonal
Form:
Liquid
Regulatory Status:
RUO
Formulation:
PBS with 0.09% sodium azide; pH 7.2
Gene Alias:
simian virus 5 antibody; SPV5gp2; sv5; V5; v-5; V5 Epitope Tag
Gene Symbols:
__
Primary or Secondary:
Primary
Content And Storage:
4° C
Gene:
__
Antigen: ROR gamma (t)
Applications: Immunoprecipitation, Western Blot
Conjugate: Unconjugated
Host Species: Rat
Target Species: Human, Mouse, Rhesus Monkey
Gene Accession No.: P51449, P51450
Gene ID (Entrez): 19885, 6097, 717052
Isotype: IgG2a κ
Purification Method: Affinity chromatography
Product Type: Antibody
Concentration: 0.5 mg/mL
Classification: Monoclonal
Form: Liquid
Regulatory Status: RUO
Formulation: PBS with 0.09% sodium azide; pH 7.2
Gene Alias: EGK_01272; IMD42; MGC129539; NR1F3; nuclear receptor ROR-gamma; Nuclear receptor RZR-gamma; nuclear receptor subfamily 1 group F member 3; RAR related orphan receptor C; RAR-related orphan nuclear receptor variant 2; RAR-related orphan receptor C; RAR-related orphan receptor C, isoform a; RAR-related orphan receptor gamma; retinoic acid-binding receptor gamma; retinoid-related orphan receptor gamma; retinoid-related orphan receptor-gamma; ROR Gamma; ROR gamma t; Rorc; Rorg; RORgamma; RORgt; RP11-98D18.11-001; RZRG; RZR-GAMMA; Thor; Thymus orphan receptor; TOR
Gene Symbols: Rorc
Primary or Secondary: Primary
Content And Storage: 4° C
Gene: Rorc
Antigen:
ROR gamma (t)
Applications:
Immunoprecipitation, Western Blot
Conjugate:
Unconjugated
Host Species:
Rat
Target Species:
Human, Mouse, Rhesus Monkey
Gene Accession No.:
P51449, P51450
Gene ID (Entrez):
19885, 6097, 717052
Isotype:
IgG2a κ
Purification Method:
Affinity chromatography
Product Type:
Antibody
Concentration:
0.5 mg/mL
Classification:
Monoclonal
Form:
Liquid
Regulatory Status:
RUO
Formulation:
PBS with 0.09% sodium azide; pH 7.2
Gene Alias:
EGK_01272; IMD42; MGC129539; NR1F3; nuclear receptor ROR-gamma; Nuclear receptor RZR-gamma; nuclear receptor subfamily 1 group F member 3; RAR related orphan receptor C; RAR-related orphan nuclear receptor variant 2; RAR-related orphan receptor C; RAR-related orphan receptor C, isoform a; RAR-related orphan receptor gamma; retinoic acid-binding receptor gamma; retinoid-related orphan receptor gamma; retinoid-related orphan receptor-gamma; ROR Gamma; ROR gamma t; Rorc; Rorg; RORgamma; RORgt; RP11-98D18.11-001; RZRG; RZR-GAMMA; Thor; Thymus orphan receptor; TOR
Gene Symbols:
Rorc
Primary or Secondary:
Primary
Content And Storage:
4° C
Gene:
Rorc