7069890
CD314 (NKG2D) Monoclonal Antibody (CX5), Functional Grade, eBioscience™, Invitrogen™
Rat Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
CD314 (NKG2D)
Concentration
1 mg/mL
Classification
Monoclonal
Form
Liquid
Regulatory Status
RUO
Formulation
PBS with no preservative; pH 7.2
Gene Alias
CD314; D12S2489E; D6H12S2489E; killer cell lectin like receptor K1; Killer cell lectin-like receptor subfamily K member 1; killer cell lectin-like receptor subfamily K, member 1; KLR; Klrk1; natural killer cell group 2D; natural killer cell receptor; NK cell receptor D; NK lectin-like receptor; Nkg2d; NKG2-D; NKG2-D type II integral membrane protein; NKG2-D-activating NK receptor; NKLLR; Nkrp2; NKR-P2; NKR-P2, ortholog of human NKG2D
Gene Symbols
Klrk1
Primary or Secondary
Primary
Content And Storage
4° C
Gene
Klrk1
Clone
CX5
Applications
Flow Cytometry, Functional Assay, Neutralization
Conjugate
Functional Grade
Host Species
Rat
Target Species
Mouse
Gene Accession No.
O54709
Gene ID (Entrez)
27007
Isotype
IgG1 κ
Purification Method
Affinity chromatography
Product Type
Antibody
Description
- Description: The CX5 monoclonal antibody reacts with the mouse NKG2D, a lectin-like molecule expressed on both human and mouse NK cells
- Mouse NKG2D binds to retinoic acid-inducible RAE-1alpha, -beta, -gamma, -delta, -ε and the minor histocompatibility molecule H60 and has the ability to costimulate multiple NK activation receptors, through the DAP12/DAP10 adaptor molecules
- NKG2D is expressed by all spleen and liver NK cells, NK1.1^+ thymocytes, in vitro activated LAK cells, and a subset of splenic NKT cells
- Applications Reported: The CX5 antibody has been reported for use in flow cytometric analysis
- It has also been reported in blocking of binding of NKG2D to its ligands, RAE-1 and H60, and inhibition NKG2D-dependent NK cell-mediated cytotoxicity against NKG2D ligand-bearing tumors in vitro and in vivo
- Applications Tested: The CX5 antibody has been tested by flow cytometric analysis of mouse splenocytes
- This can be used at less than or equal to 0.5 μg per test
- A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL
- Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test
- It is recommended that when using this antibody for staining the secondary must be Biotin anti-rat (cat 13-4813)
- Other secondaries may give suboptimal staining
- Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation
- NK cells can regulate specific humoral and cell-mediated immunity, and preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function
- The NK gene encodes a member of the NKG2 family, and the encoded transmembrane protein is characterized by a type II membrane orientation (extracellular C terminus) and the presence of a C-type lectin domain
- The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed in NK cells.
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Antigen: CD314 (NKG2D)
Concentration: 1 mg/mL
Classification: Monoclonal
Form: Liquid
Regulatory Status: RUO
Formulation: PBS with no preservative; pH 7.2
Gene Alias: CD314; D12S2489E; D6H12S2489E; killer cell lectin like receptor K1; Killer cell lectin-like receptor subfamily K member 1; killer cell lectin-like receptor subfamily K, member 1; KLR; Klrk1; natural killer cell group 2D; natural killer cell receptor; NK cell receptor D; NK lectin-like receptor; Nkg2d; NKG2-D; NKG2-D type II integral membrane protein; NKG2-D-activating NK receptor; NKLLR; Nkrp2; NKR-P2; NKR-P2, ortholog of human NKG2D
Gene Symbols: Klrk1
Primary or Secondary: Primary
Content And Storage: 4° C
Gene: Klrk1
Clone: CX5
Applications: Flow Cytometry, Functional Assay, Neutralization
Conjugate: Functional Grade
Host Species: Rat
Target Species: Mouse
Gene Accession No.: O54709
Gene ID (Entrez): 27007
Isotype: IgG1 κ
Purification Method: Affinity chromatography
Product Type: Antibody
Antigen:
CD314 (NKG2D)
Concentration:
1 mg/mL
Classification:
Monoclonal
Form:
Liquid
Regulatory Status:
RUO
Formulation:
PBS with no preservative; pH 7.2
Gene Alias:
CD314; D12S2489E; D6H12S2489E; killer cell lectin like receptor K1; Killer cell lectin-like receptor subfamily K member 1; killer cell lectin-like receptor subfamily K, member 1; KLR; Klrk1; natural killer cell group 2D; natural killer cell receptor; NK cell receptor D; NK lectin-like receptor; Nkg2d; NKG2-D; NKG2-D type II integral membrane protein; NKG2-D-activating NK receptor; NKLLR; Nkrp2; NKR-P2; NKR-P2, ortholog of human NKG2D
Gene Symbols:
Klrk1
Primary or Secondary:
Primary
Content And Storage:
4° C
Gene:
Klrk1
Clone:
CX5
Applications:
Flow Cytometry, Functional Assay, Neutralization
Conjugate:
Functional Grade
Host Species:
Rat
Target Species:
Mouse
Gene Accession No.:
O54709
Gene ID (Entrez):
27007
Isotype:
IgG1 κ
Purification Method:
Affinity chromatography
Product Type:
Antibody
Antigen: CD262 (DR5)
Concentration: 1 mg/mL
Classification: Monoclonal
Form: Liquid
Regulatory Status: RUO
Formulation: PBS with no preservative; pH 7.2
Gene Alias: apoptosis inducing protein TRICK2A/2B; apoptosis inducing receptor TRAIL-R2; CD262; cytotoxic TRAIL receptor-2; death domain containing receptor for TRAIL/Apo-2L; death receptor 5; Dr5; dr-5; Fas-like protein; KILLER; KILLER/DR5; KILLER/DR5 TRAIL death-inducing receptor; Ly98; MK; p53-regulated DNA damage-inducible cell death receptor(killer); sCD262; soluble CD262; TNF receptor superfamily member 10b; TNF-related apoptosis-inducing ligand receptor 2; TNFRSF10B; TRAIL receptor 2; TRAILR2; TRAIL-R2; TRICK2; TRICK2A; TRICK2B; TRICKB; tumor necrosis factor receptor superfamily member 10B; tumor necrosis factor receptor superfamily, member 10b; tumor necrosis factor receptor-like protein ZTNFR9; UNQ160/PRO186; ZTNFR9
Gene Symbols: TNFRSF10B
Primary or Secondary: Primary
Content And Storage: 4° C
Gene: TNFRSF10B
Clone: MD5-1
Applications: Flow Cytometry, Functional Assay
Conjugate: Functional Grade
Host Species: Armenian Hamster
Target Species: Mouse
Gene Accession No.: Q9QZM4
Gene ID (Entrez): 21933
Isotype: IgG
Purification Method: Affinity chromatography
Product Type: Antibody
Antigen:
CD262 (DR5)
Concentration:
1 mg/mL
Classification:
Monoclonal
Form:
Liquid
Regulatory Status:
RUO
Formulation:
PBS with no preservative; pH 7.2
Gene Alias:
apoptosis inducing protein TRICK2A/2B; apoptosis inducing receptor TRAIL-R2; CD262; cytotoxic TRAIL receptor-2; death domain containing receptor for TRAIL/Apo-2L; death receptor 5; Dr5; dr-5; Fas-like protein; KILLER; KILLER/DR5; KILLER/DR5 TRAIL death-inducing receptor; Ly98; MK; p53-regulated DNA damage-inducible cell death receptor(killer); sCD262; soluble CD262; TNF receptor superfamily member 10b; TNF-related apoptosis-inducing ligand receptor 2; TNFRSF10B; TRAIL receptor 2; TRAILR2; TRAIL-R2; TRICK2; TRICK2A; TRICK2B; TRICKB; tumor necrosis factor receptor superfamily member 10B; tumor necrosis factor receptor superfamily, member 10b; tumor necrosis factor receptor-like protein ZTNFR9; UNQ160/PRO186; ZTNFR9
Gene Symbols:
TNFRSF10B
Primary or Secondary:
Primary
Content And Storage:
4° C
Gene:
TNFRSF10B
Clone:
MD5-1
Applications:
Flow Cytometry, Functional Assay
Conjugate:
Functional Grade
Host Species:
Armenian Hamster
Target Species:
Mouse
Gene Accession No.:
Q9QZM4
Gene ID (Entrez):
21933
Isotype:
IgG
Purification Method:
Affinity chromatography
Product Type:
Antibody
Antigen: KLRG1
Concentration: 1 mg/mL
Classification: Monoclonal
Form: Liquid
Regulatory Status: RUO
Formulation: PBS with no preservative; pH 7.2
Gene Alias: 2F1; 2F1-Ag; CLEC15A; C-type lectin domain family 15 member A; C-type lectin domain family 15, member A; ITIM-containing receptor MAFA-L; killer cell lectin like receptor G1; killer cell lectin-like receptor subfamily G member 1; killer cell lectin-like receptor subfamily G, member 1; Klrg1; Mafa; MAFA-2F1; MAFAL; MAFA-L; MAFA-LIKE; MAFA-like receptor; Mast cell function-associated antigen; mast cell function-associated antigen (ITIM-containing); mast cell function-associated antigen 2F1; natural killer cell receptor
Gene Symbols: Klrg1
Primary or Secondary: Primary
Content And Storage: 4° C
Gene: Klrg1
Clone: 2F1
Applications: Flow Cytometry, Functional Assay
Conjugate: Functional Grade
Host Species: Syrian Hamster
Target Species: Mouse
Gene Accession No.: O88713
Gene ID (Entrez): 50928
Isotype: IgG
Purification Method: Affinity chromatography
Product Type: Antibody
Antigen:
KLRG1
Concentration:
1 mg/mL
Classification:
Monoclonal
Form:
Liquid
Regulatory Status:
RUO
Formulation:
PBS with no preservative; pH 7.2
Gene Alias:
2F1; 2F1-Ag; CLEC15A; C-type lectin domain family 15 member A; C-type lectin domain family 15, member A; ITIM-containing receptor MAFA-L; killer cell lectin like receptor G1; killer cell lectin-like receptor subfamily G member 1; killer cell lectin-like receptor subfamily G, member 1; Klrg1; Mafa; MAFA-2F1; MAFAL; MAFA-L; MAFA-LIKE; MAFA-like receptor; Mast cell function-associated antigen; mast cell function-associated antigen (ITIM-containing); mast cell function-associated antigen 2F1; natural killer cell receptor
Gene Symbols:
Klrg1
Primary or Secondary:
Primary
Content And Storage:
4° C
Gene:
Klrg1
Clone:
2F1
Applications:
Flow Cytometry, Functional Assay
Conjugate:
Functional Grade
Host Species:
Syrian Hamster
Target Species:
Mouse
Gene Accession No.:
O88713
Gene ID (Entrez):
50928
Isotype:
IgG
Purification Method:
Affinity chromatography
Product Type:
Antibody
Antigen: FceR1 alpha
Concentration: 1 mg/mL
Classification: Monoclonal
Form: Liquid
Regulatory Status: RUO
Formulation: PBS with no preservative; pH 7.2
Gene Alias: alpha polypeptide; fc epsilon r1; Fc epsilon receptor Ia; Fc epsilon RI alpha-chain; Fc fragment of IgE receptor Ia; Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide; Fc IgE receptor, alpha polypeptide; Fc receptor, IgE, high affinity I, alpha polypeptide; Fce1a; Fc-epsilon RI-alpha; fcepsilonri; FCER1A; FcERI; Fcr-5; high affinity immunoglobulin epsilon receptor alpha-subunit; high affinity immunoglobulin epsilon receptor subunit alpha; IgE Fc receptor subunit alpha; Iger01; immunoglobulin E receptor, high-affinity, of mast cells, alpha polypeptide; RATIGER01; RP11-550P17.3
Gene Symbols: FCER1A
Primary or Secondary: Primary
Content And Storage: 4° C
Gene: FCER1A
Clone: MAR-1
Applications: Flow Cytometry, Functional Assay, Neutralization
Conjugate: Functional Grade
Host Species: Armenian Hamster
Target Species: Mouse
Gene Accession No.: P20489
Gene ID (Entrez): 14125
Isotype: IgG
Purification Method: Affinity chromatography
Product Type: Antibody
Antigen:
FceR1 alpha
Concentration:
1 mg/mL
Classification:
Monoclonal
Form:
Liquid
Regulatory Status:
RUO
Formulation:
PBS with no preservative; pH 7.2
Gene Alias:
alpha polypeptide; fc epsilon r1; Fc epsilon receptor Ia; Fc epsilon RI alpha-chain; Fc fragment of IgE receptor Ia; Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide; Fc IgE receptor, alpha polypeptide; Fc receptor, IgE, high affinity I, alpha polypeptide; Fce1a; Fc-epsilon RI-alpha; fcepsilonri; FCER1A; FcERI; Fcr-5; high affinity immunoglobulin epsilon receptor alpha-subunit; high affinity immunoglobulin epsilon receptor subunit alpha; IgE Fc receptor subunit alpha; Iger01; immunoglobulin E receptor, high-affinity, of mast cells, alpha polypeptide; RATIGER01; RP11-550P17.3
Gene Symbols:
FCER1A
Primary or Secondary:
Primary
Content And Storage:
4° C
Gene:
FCER1A
Clone:
MAR-1
Applications:
Flow Cytometry, Functional Assay, Neutralization
Conjugate:
Functional Grade
Host Species:
Armenian Hamster
Target Species:
Mouse
Gene Accession No.:
P20489
Gene ID (Entrez):
14125
Isotype:
IgG
Purification Method:
Affinity chromatography
Product Type:
Antibody