7082874
Activated Mac-1 (CD11b) Mouse anti-Human, Brilliant Violet 421, Clone: CBRM1/5, BD
Mouse Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
Activated Mac-1 (CD11b)
Classification
Monoclonal
Host Species
Mouse
Target Species
Human
Gene Alias
MAC-1A, Mac-1, ITGAM, Integrin alpha M, CR3A, CR-3 alpha, Mo1, SLEB6
Isotype
IgG1 κ
Purification Method
Affinity Purified
Clone
CBRM1/5
Conjugate
Brilliant Violet 421
Regulatory Status
RUO
Formulation
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Immunogen
Human Mac-1 Protein
Primary or Secondary
Primary
Content And Storage
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Description
- The CBRM1/5 monoclonal antibody specifically recognizes an activated form of the CD11b molecule that is expressed on activated monocytes, granulocytes, NK cells, and subsets of T and B cells
- CD11b is also known as the alpha chain of either Mac-1 (MAC-1A/Mac-1 ) or Complement receptor 3 (CR3A)
- CD11b is a ñ165 kDa type I transmembrane glycoprotein that is encoded by ITGAM (Integrin alpha M)
- CD11b associates with CD18 (Integrin beta 2) to form the CD11b/CD18 complex, which is also known as the Mac-1 integrin or the Complement receptor 3 (CR3)
- CD11b functions in cell-cell and cell-substrate interactions involved in leucocyte activation, adhesion, migration, phagocytosis, and other effector functions
- CD11b/CD18 serves as a receptor for multiple ligands including iC3b, CD50 (ICAM-3), CD54 (ICAM-1), CD102 (ICAM-2), and fibrinogen
- The CBRM1/5 reportedly inhibits Mac-1-dependent adhesion of stimulated neutrophils to CD54 or fibrinogen
- The antibody was conjugated to BD Horizon BV421 which is part of the BD Horizon Brilliant™ Violet family of dyes
- With an Ex Max of 407nm and Em Max at 421nm, BD Horizon BV421 can be excited by the violet laser and detected in the standard Pacific Blue™ filter set (eg, 450/50nm filter)
- BD Horizon BV421 conjugates are very bright, often exhibiting a 10 fold improvement in brightness compared to Pacific Blue conjugates
- BV421 is a polymer-based dye excited by the violet laser and is one of the brightest fluorochromes offered by BD Biosciences
- Conjugates are typically 10 times brighter than Pacific Blue™ conjugates and are often as bright as or brighter than PE conjugates
- Due to nearly identical excitation and emission properties but different spillover characteristics, BD Horizon BV421, Pacific Blue™, and BD Horizon™ V450 cannot be used simultaneously.
Compare Similar Items
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Antigen: Activated Mac-1 (CD11b)
Classification: Monoclonal
Host Species: Mouse
Target Species: Human
Gene Alias: MAC-1A, Mac-1, ITGAM, Integrin alpha M, CR3A, CR-3 alpha, Mo1, SLEB6
Isotype: IgG1 κ
Purification Method: Affinity Purified
Clone: CBRM1/5
Conjugate: Brilliant Violet 421
Regulatory Status: RUO
Formulation: Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Immunogen: Human Mac-1 Protein
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Antigen:
Activated Mac-1 (CD11b)
Classification:
Monoclonal
Host Species:
Mouse
Target Species:
Human
Gene Alias:
MAC-1A, Mac-1, ITGAM, Integrin alpha M, CR3A, CR-3 alpha, Mo1, SLEB6
Isotype:
IgG1 κ
Purification Method:
Affinity Purified
Clone:
CBRM1/5
Conjugate:
Brilliant Violet 421
Regulatory Status:
RUO
Formulation:
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Immunogen:
Human Mac-1 Protein
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Antigen: CCR8 (CD198)
Classification: Monoclonal
Host Species: Mouse
Target Species: Human
Gene Alias: CCR8, CKR-L1, CKRL1, CMKBR8, CMKBRL2, CY6, GPR-CY6, GPRCY6, MGC129966, MGC1
Isotype: IgG2a κ
Purification Method: Affinity Purified
Clone: 433H
Conjugate: Brilliant Violet 421
Regulatory Status: RUO
Formulation: Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Immunogen: Human CCR8 Transfected Cell Line
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Antigen:
CCR8 (CD198)
Classification:
Monoclonal
Host Species:
Mouse
Target Species:
Human
Gene Alias:
CCR8, CKR-L1, CKRL1, CMKBR8, CMKBRL2, CY6, GPR-CY6, GPRCY6, MGC129966, MGC1
Isotype:
IgG2a κ
Purification Method:
Affinity Purified
Clone:
433H
Conjugate:
Brilliant Violet 421
Regulatory Status:
RUO
Formulation:
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Immunogen:
Human CCR8 Transfected Cell Line
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Antigen: CD317 (BST2)
Classification: Monoclonal
Host Species: Mouse
Target Species: Baboon, Cynomolgus, Human, Rhesus Monkey
Gene Alias: BST2, BST-2, bone marrow stromal antigen 2, HM1.24 antigen, Tetherin
Isotype: IgG2a κ
Purification Method: Affinity Purified
Clone: Y129 (also known as HM1.24)
Conjugate: Brilliant Violet 421
Regulatory Status: RUO
Formulation: Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Immunogen: Human KPC-32 Plasma Cell Line
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Antigen:
CD317 (BST2)
Classification:
Monoclonal
Host Species:
Mouse
Target Species:
Baboon, Cynomolgus, Human, Rhesus Monkey
Gene Alias:
BST2, BST-2, bone marrow stromal antigen 2, HM1.24 antigen, Tetherin
Isotype:
IgG2a κ
Purification Method:
Affinity Purified
Clone:
Y129 (also known as HM1.24)
Conjugate:
Brilliant Violet 421
Regulatory Status:
RUO
Formulation:
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Immunogen:
Human KPC-32 Plasma Cell Line
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Antigen: IgE
Classification: Monoclonal
Host Species: Mouse
Target Species: Human
Gene Alias: Immunoglobulin E, IGHE, IGHε, Ig epsilon chain constant region
Isotype: IgG2a κ
Purification Method: Affinity Purified
Clone: G7-26
Conjugate: Brilliant Violet 421
Regulatory Status: RUO
Formulation: Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Immunogen: __
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Antigen:
IgE
Classification:
Monoclonal
Host Species:
Mouse
Target Species:
Human
Gene Alias:
Immunoglobulin E, IGHE, IGHε, Ig epsilon chain constant region
Isotype:
IgG2a κ
Purification Method:
Affinity Purified
Clone:
G7-26
Conjugate:
Brilliant Violet 421
Regulatory Status:
RUO
Formulation:
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Immunogen:
__
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.