CD161 Monoclonal Antibody (HP-3G10), eFluor™ 450, eBioscience™, Invitrogen™
Mouse Monoclonal Antibody
Manufacturer: Fischer Scientific
The price for this product is unavailable. Please request a quote
Antigen
CD161
Concentration
5 μL/Test
Classification
Monoclonal
Form
Liquid
Regulatory Status
RUO
Formulation
PBS with 0.2% BSA and 0.09% sodium azide; pH 7.2
Gene Alias
4930431A04Rik; Antigen 3.2.3; CD161; CD161 antigen-like family member A; CD161 antigen-like family member B; CD161a; CD161b; CLEC5B; C-type lectin domain family 5 member B; EMBL:AAQ11375.1}; Gm4696; HNKR-P1a; Immunoreceptor NKR-P1E; immunoreceptor NKR-P1G; inhibitory receptor NKR-P1B; killer cell lectin like receptor B1; killer cell lectin-like receptor subfamily A member 1 complex; killer cell lectin-like receptor subfamily B member 1; killer cell lectin-like receptor subfamily B member 1 complex; killer cell lectin-like receptor subfamily B member 1A; killer cell lectin-like receptor subfamily B member 1B; killer cell lectin-like receptor subfamily B member 1B allele A; Killer cell lectin-like receptor subfamily B member 1B allele B; killer cell lectin-like receptor subfamily B member 1B allele C; killer cell lectin-like receptor subfamily B member 1D; killer cell lectin-like receptor subfamily B member 1F; killer cell lectin-like receptor subfamily B member 1G; killer cell lectin-like receptor subfamily B, member 1; killer cell lectin-like receptor subfamily B, member 1A; Klrb1; Klrb1a; Klrb1b; klrb1b {ECO:0000312; Klrb1d; Klrb1f; Klrb1g; Klrb6; lectin-like transmembrane protein Nkrp1g; Ly55; Ly-55; Ly55a; ly-55A; Ly55b; ly-55b; Ly55d; ly-55d; lymphocyte antigen 55; lymphocyte antigen 55 complex, locus A; lymphocyte antigen 55 complex, locus B; lymphocyte antigen 55 complex, locus D; lymphocyte antigen 55A; lymphocyte antigen 55b; lymphocyte antigen 55d; MGC138614; natural killer cell receptor; natural killer cell receptor protein NKR-P1A; natural killer cell receptor protein NKR-P1B; natural killer cell receptor-P1; natural killer cell surface protein NKR-P1B allele B6; Natural killer cell surface protein NKR-P1B allele RNK/SD/BN/F344; natural killer cell surface protein NKR-P1B allele SJL/BALB; natural killer cell surface protein NKR-P1B allele TO; natural killer cell surface protein NKR-P1G; Natural killer cell surface protein P1-2; natural killer cell surface protein P1-3.2.3; Natural killer cell surface protein P1A; natural killer lectin-like receptor 1E; natural killer lectin-like receptor protein 1 e; NKR; NKR-P1; NKR-P1 2; NKR-P1 3.2.3; NKR-P1 34; NKR-P1.7; NKRP12; NKRP1A; NKR-P1A; Nkrp1-a; Nkrp1b; Nkr-p1b; Nkrp1-b; Nkrp1d; NKR-P1D; Nkrp1e; Nkr-p1e; Nkrp-1e; Nkrp1g; NKR-P1G; RGD:2975}
Gene Symbols
Klrb1
Primary or Secondary
Primary
Content And Storage
4° C, store in dark, DO NOT FREEZE!
Gene
Klrb1
Clone
HP-3G10
Applications
Flow Cytometry
Conjugate
eFluor 450
Host Species
Mouse
Target Species
Human
Gene Accession No.
Q12918
Gene ID (Entrez)
3820
Isotype
IgG1 κ
Purification Method
Affinity chromatography
Product Type
Antibody
Related Products
Description
- Description: This HP-3G10 monoclonal antibody reacts with CD161 (also known as NKR-P1A), a member of the C-type lectin superfamily
- The human homologue of NK1.1 in C57BL/6 mice, CD161 is expressed on natural killer cells and is upregulated in response to IL-12
- CD161 can also be detected on various T cell subsets, including memory/effector CD4+ T cells, CD8+ T cells, gamma delta TCR T cells, and a subset of CD3+ thymocytes
- Finally, CD161 expression has been demonstrated on human Th17 CD4+ T cells
- The function of this receptor is unclear although studies suggest a possible stimulatory role
- Nevertheless, Lectin-like transcript-1 (LLT1), which is also known as osteoclast inhibitory lectin, has been identified as the ligand for CD161
- Applications Reported: This HP-3G10 antibody has been reported for use in flow cytometric analysis
- Applications Tested: This HP-3G10 antibody has been pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells
- This can be used at 5 μL (0.25 μg) per test
- A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL
- Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test
- eFluor™ 450 is an alternative to Pacific Blue™
- eFluor™ 450 emits at 445 nm and is excited with the Violet laser (405 nm)
- Please make sure that your instrument is capable of detecting this fluorochome
- KLRB1 (Killer cell lectin like receptor subfamily B, member 1, CD-161) protein is classified as a type II membrane protein because it has an external C terminus
- KLRB1 cell surface antigen is expressed by almost all NK cells and in a small subset of CD3+ve T cells
- KLRB1 is a homodimeric cell surface protein, comprising two chains with molecular weights ranging from 40-44kDa
- KLRB1 plays an inhibitory role on natural killer (NK) cells
- Activation of KLRB1 leads to acid sphingomyelnase/SMPD1 stimulation and an increase in intracellular ceramide
- Moreover, there is also an activation of AKT1/PKB and RPS6KA1/RSK1 kinase stimulation, and T cell proliferation by anti-CD3
- KLRB1 acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope and to the N-acetyllactosamine epitope
- KLRB1 also binds to CLEC2D/LLT1 as a ligand, and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells
- The KLRB1 protein contains an extracellular domain with several motifs characteristic of C-type lectins, a transmembrane domain, and a cytoplasmic domain.
Compare Similar Items
Show Difference
Antigen: CD161
Concentration: 5 μL/Test
Classification: Monoclonal
Form: Liquid
Regulatory Status: RUO
Formulation: PBS with 0.2% BSA and 0.09% sodium azide; pH 7.2
Gene Alias: 4930431A04Rik; Antigen 3.2.3; CD161; CD161 antigen-like family member A; CD161 antigen-like family member B; CD161a; CD161b; CLEC5B; C-type lectin domain family 5 member B; EMBL:AAQ11375.1}; Gm4696; HNKR-P1a; Immunoreceptor NKR-P1E; immunoreceptor NKR-P1G; inhibitory receptor NKR-P1B; killer cell lectin like receptor B1; killer cell lectin-like receptor subfamily A member 1 complex; killer cell lectin-like receptor subfamily B member 1; killer cell lectin-like receptor subfamily B member 1 complex; killer cell lectin-like receptor subfamily B member 1A; killer cell lectin-like receptor subfamily B member 1B; killer cell lectin-like receptor subfamily B member 1B allele A; Killer cell lectin-like receptor subfamily B member 1B allele B; killer cell lectin-like receptor subfamily B member 1B allele C; killer cell lectin-like receptor subfamily B member 1D; killer cell lectin-like receptor subfamily B member 1F; killer cell lectin-like receptor subfamily B member 1G; killer cell lectin-like receptor subfamily B, member 1; killer cell lectin-like receptor subfamily B, member 1A; Klrb1; Klrb1a; Klrb1b; klrb1b {ECO:0000312; Klrb1d; Klrb1f; Klrb1g; Klrb6; lectin-like transmembrane protein Nkrp1g; Ly55; Ly-55; Ly55a; ly-55A; Ly55b; ly-55b; Ly55d; ly-55d; lymphocyte antigen 55; lymphocyte antigen 55 complex, locus A; lymphocyte antigen 55 complex, locus B; lymphocyte antigen 55 complex, locus D; lymphocyte antigen 55A; lymphocyte antigen 55b; lymphocyte antigen 55d; MGC138614; natural killer cell receptor; natural killer cell receptor protein NKR-P1A; natural killer cell receptor protein NKR-P1B; natural killer cell receptor-P1; natural killer cell surface protein NKR-P1B allele B6; Natural killer cell surface protein NKR-P1B allele RNK/SD/BN/F344; natural killer cell surface protein NKR-P1B allele SJL/BALB; natural killer cell surface protein NKR-P1B allele TO; natural killer cell surface protein NKR-P1G; Natural killer cell surface protein P1-2; natural killer cell surface protein P1-3.2.3; Natural killer cell surface protein P1A; natural killer lectin-like receptor 1E; natural killer lectin-like receptor protein 1 e; NKR; NKR-P1; NKR-P1 2; NKR-P1 3.2.3; NKR-P1 34; NKR-P1.7; NKRP12; NKRP1A; NKR-P1A; Nkrp1-a; Nkrp1b; Nkr-p1b; Nkrp1-b; Nkrp1d; NKR-P1D; Nkrp1e; Nkr-p1e; Nkrp-1e; Nkrp1g; NKR-P1G; RGD:2975}
Gene Symbols: Klrb1
Primary or Secondary: Primary
Content And Storage: 4° C, store in dark, DO NOT FREEZE!
Gene: Klrb1
Clone: HP-3G10
Applications: Flow Cytometry
Conjugate: eFluor 450
Host Species: Mouse
Target Species: Human
Gene Accession No.: Q12918
Gene ID (Entrez): 3820
Isotype: IgG1 κ
Purification Method: Affinity chromatography
Product Type: Antibody
Antigen: CD317 (BST2, PDCA-1)
Concentration: 0.2 mg/mL
Classification: Monoclonal
Form: Liquid
Regulatory Status: RUO
Formulation: PBS with 0.09% sodium azide; pH 7.2
Gene Alias: 2310015I10Rik; bone marrow stromal antigen 2; bone marrow stromal cell antigen 2; Bst2; BST-2; C87040; CD317; Damp1; DAMP-1; DAMP-1 protein homolog; GREG; HM1.24 antigen; NPC-A-7; PDCA-1; protein DAMP-1; TETHERIN
Gene Symbols: Bst2
Primary or Secondary: Primary
Content And Storage: 4° C, store in dark, DO NOT FREEZE!
Gene: Bst2
Clone: eBio927
Applications: Flow Cytometry
Conjugate: eFluor 450
Host Species: Rat
Target Species: Mouse
Gene Accession No.: Q8R2Q8
Gene ID (Entrez): 69550
Isotype: IgG2b κ
Purification Method: Affinity chromatography
Product Type: Antibody
Antigen: CD335 (NKp46)
Concentration: 0.2 mg/mL
Classification: Monoclonal
Form: Liquid
Regulatory Status: RUO
Formulation: PBS with 0.09% sodium azide; pH 7.2
Gene Alias: 1-Mar; activating receptor 1; Ar1; CD335; hNKp46; Kilr1; KILR-1; LY94; Ly-94; lymphocyte antigen 94; Lymphocyte antigen 94 homolog; lymphocyte antigen 94 homolog (activating NK-receptor; lymphocyte antigen 94 homolog (activating NK-receptor; NK-p46); mAR-1; MAR1 (mouse activating receptor 1); mNKp46; natural cytotoxicity triggering receptor 1; Natural killer cell p46-related protein; natural killer cell receptor; Ncr1; NK cell-activating receptor; NK receptor KILR-1; NKACTR; Nkp46; NK-p46; NK-p46); rAR-1; rat-activating receptor 1
Gene Symbols: NCR1
Primary or Secondary: Primary
Content And Storage: 4° C, store in dark, DO NOT FREEZE!
Gene: NCR1
Clone: 29A1.4
Applications: Flow Cytometry
Conjugate: eFluor 450
Host Species: Rat
Target Species: Mouse
Gene Accession No.: Q8C567
Gene ID (Entrez): 17086
Isotype: IgG2a κ
Purification Method: Affinity chromatography
Product Type: Antibody
