CD4 Mouse anti-Human, Brilliant Violet 510, Clone: SK3, BD

Description

• The SK3 monoclonal antibody specifically binds to CD4
• The CD4 antigen is a 55 kDa type 1 transmembrane glycoprotein that belongs to the immunoglobulin superfamily
• It is expressed on T-helper/inducer lymphocytes and monocytes
• CD3+CD4+ T cells comprise approximately 28% to 58% of normal peripheral blood lymphocytes
• CD4 is also expressed on 80% to 95% of normal thymocytes
• The CD4 antigen is present in low density on the cell surface of monocytes and in the cytoplasm of monocytes and macrophages (CD3-CD4+)
• CD4 serves as a T cell coreceptor for MHC class II antigen recognition and as a receptor for the human immunodeficiency virus (HIV)
• The SK3 antibody inhibits HIV binding to CD4+ cells
• The antibody was conjugated to BD Horizon™ BV510 which is part of the BD Horizon™ Brilliant Violet™ family of dyes
• With an Ex Max of 405-nm and Em Max at 510-nm, BD Horizon™ BV510 can be excited by the violet laser and detected in the BD Horizon™ V500 (525/50-nm) filter set
• BD Horizon™ BV510 conjugates are useful for the detection of dim markers off the violet laser.