7144390
DTL/CDT2 Polyclonal Antibody, Bethyl Laboratories
Rabbit Polyclonal Antibody
Manufacturer: Fischer Scientific
The price for this product is unavailable. Please request a quote
Antigen
DTL/CDT2
Classification
Polyclonal
Form
Liquid
Regulatory Status
RUO
Formulation
TBS with 0.1% BSA and 0.09% sodium azide
Gene Alias
CDT2, DCAF2, L2DTL, RAMP, DDB1 and CUL4 associated factor 2, DDB1- and CUL4-associated factor 2, RA regulated nuclear matrix associated protein, RA-regulated nuclear matrix-associated protein, denticleless protein homolog, lethal(2) denticleless protein homolog, retinoic acid-regulated
Immunogen
Between 680 and C-term
Primary or Secondary
Primary
Content And Storage
4° C
Gene
DTL
Applications
Immunohistochemistry
Conjugate
Unconjugated
Host Species
Rabbit
Target Species
Human, Mouse
Gene Accession No.
Q3TLR7, Q9NZJ0
Gene ID (Entrez)
51514, 76843
Isotype
IgG
Purification Method
Antigen affinity chromatography
Product Type
Antibody
Related Products
Description
- The recommended shelf life for this product is 1 year from date of receipt
- Based on 100% sequence identity, this antibody is predicted to react with Orangutan, Monkey, Gorilla, Chimpanzee, Northern white-cheeked gibbon and Crab-eating macaque Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis
- The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1 and CDKN1A/p21(CIP1)
- CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication
- CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing
- Most substrates require their interaction with PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation
- In undamaged proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis.
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Antigen: DTL/CDT2
Classification: Polyclonal
Form: Liquid
Regulatory Status: RUO
Formulation: TBS with 0.1% BSA and 0.09% sodium azide
Gene Alias: CDT2, DCAF2, L2DTL, RAMP, DDB1 and CUL4 associated factor 2, DDB1- and CUL4-associated factor 2, RA regulated nuclear matrix associated protein, RA-regulated nuclear matrix-associated protein, denticleless protein homolog, lethal(2) denticleless protein homolog, retinoic acid-regulated
Immunogen: Between 680 and C-term
Primary or Secondary: Primary
Content And Storage: 4° C
Gene: DTL
Applications: Immunohistochemistry
Conjugate: Unconjugated
Host Species: Rabbit
Target Species: Human, Mouse
Gene Accession No.: Q3TLR7, Q9NZJ0
Gene ID (Entrez): 51514, 76843
Isotype: IgG
Purification Method: Antigen affinity chromatography
Product Type: Antibody
Antigen:
DTL/CDT2
Classification:
Polyclonal
Form:
Liquid
Regulatory Status:
RUO
Formulation:
TBS with 0.1% BSA and 0.09% sodium azide
Gene Alias:
CDT2, DCAF2, L2DTL, RAMP, DDB1 and CUL4 associated factor 2, DDB1- and CUL4-associated factor 2, RA regulated nuclear matrix associated protein, RA-regulated nuclear matrix-associated protein, denticleless protein homolog, lethal(2) denticleless protein homolog, retinoic acid-regulated
Immunogen:
Between 680 and C-term
Primary or Secondary:
Primary
Content And Storage:
4° C
Gene:
DTL
Applications:
Immunohistochemistry
Conjugate:
Unconjugated
Host Species:
Rabbit
Target Species:
Human, Mouse
Gene Accession No.:
Q3TLR7, Q9NZJ0
Gene ID (Entrez):
51514, 76843
Isotype:
IgG
Purification Method:
Antigen affinity chromatography
Product Type:
Antibody
Antigen: BubR1
Classification: Polyclonal
Form: Liquid
Regulatory Status: RUO
Formulation: TBS with 0.1% BSA and 0.09% sodium azide
Gene Alias: BUB1B, Budding Uninhibited by Benzimidazoles 1 beta, hBUBR1, MAD3L
Immunogen: Between 1 and 50
Primary or Secondary: Primary
Content And Storage: 4° C
Gene: BUB1B
Applications: Immunohistochemistry
Conjugate: Unconjugated
Host Species: Rabbit
Target Species: Human
Gene Accession No.: O60566
Gene ID (Entrez): 701
Isotype: IgG
Purification Method: Antigen affinity chromatography
Product Type: Antibody
Antigen:
BubR1
Classification:
Polyclonal
Form:
Liquid
Regulatory Status:
RUO
Formulation:
TBS with 0.1% BSA and 0.09% sodium azide
Gene Alias:
BUB1B, Budding Uninhibited by Benzimidazoles 1 beta, hBUBR1, MAD3L
Immunogen:
Between 1 and 50
Primary or Secondary:
Primary
Content And Storage:
4° C
Gene:
BUB1B
Applications:
Immunohistochemistry
Conjugate:
Unconjugated
Host Species:
Rabbit
Target Species:
Human
Gene Accession No.:
O60566
Gene ID (Entrez):
701
Isotype:
IgG
Purification Method:
Antigen affinity chromatography
Product Type:
Antibody
Antigen: CASC5
Classification: Polyclonal
Form: Liquid
Regulatory Status: RUO
Formulation: TBS with 0.1% BSA and 0.09% sodium azide
Gene Alias: Protein CASC5, Cancer susceptibility candidate gene 5 protein homolog, Kinetochore-null protein 1, Casc5, Knl1
Immunogen: Between 300 and 350
Primary or Secondary: Primary
Content And Storage: 4° C
Gene: KNL1
Applications: Immunohistochemistry
Conjugate: Unconjugated
Host Species: Rabbit
Target Species: Human
Gene Accession No.: Q8NG31
Gene ID (Entrez): 57082
Isotype: IgG
Purification Method: Antigen affinity chromatography
Product Type: Antibody
Antigen:
CASC5
Classification:
Polyclonal
Form:
Liquid
Regulatory Status:
RUO
Formulation:
TBS with 0.1% BSA and 0.09% sodium azide
Gene Alias:
Protein CASC5, Cancer susceptibility candidate gene 5 protein homolog, Kinetochore-null protein 1, Casc5, Knl1
Immunogen:
Between 300 and 350
Primary or Secondary:
Primary
Content And Storage:
4° C
Gene:
KNL1
Applications:
Immunohistochemistry
Conjugate:
Unconjugated
Host Species:
Rabbit
Target Species:
Human
Gene Accession No.:
Q8NG31
Gene ID (Entrez):
57082
Isotype:
IgG
Purification Method:
Antigen affinity chromatography
Product Type:
Antibody
Antigen: MCAK
Classification: Polyclonal
Form: Liquid
Regulatory Status: RUO
Formulation: TBS with 0.1% BSA and 0.09% sodium azide
Gene Alias: RP11-269F19.1, KNSL6, MCAK, kinesin-like 6; kinesin-like protein 6; kinesin-like protein KIF2C; mitotic centromere-associated kinesin
Immunogen: Between 50 and 100
Primary or Secondary: Primary
Content And Storage: 4° C
Gene: KIF2C
Applications: Immunohistochemistry
Conjugate: Unconjugated
Host Species: Rabbit
Target Species: Human
Gene Accession No.: Q99661
Gene ID (Entrez): 11004
Isotype: IgG
Purification Method: Antigen affinity chromatography
Product Type: Antibody
Antigen:
MCAK
Classification:
Polyclonal
Form:
Liquid
Regulatory Status:
RUO
Formulation:
TBS with 0.1% BSA and 0.09% sodium azide
Gene Alias:
RP11-269F19.1, KNSL6, MCAK, kinesin-like 6; kinesin-like protein 6; kinesin-like protein KIF2C; mitotic centromere-associated kinesin
Immunogen:
Between 50 and 100
Primary or Secondary:
Primary
Content And Storage:
4° C
Gene:
KIF2C
Applications:
Immunohistochemistry
Conjugate:
Unconjugated
Host Species:
Rabbit
Target Species:
Human
Gene Accession No.:
Q99661
Gene ID (Entrez):
11004
Isotype:
IgG
Purification Method:
Antigen affinity chromatography
Product Type:
Antibody