7162913
Lap2alpha, Mouse anti-Mouse, Clone: 8C10-1H11, Millipore Sigma™
Mouse Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
Lap2alpha
Dilution
Western Blotting Analysis: A representative lot detected Lap2alpha in Western Blotting applications (Gesson, K., et. al. (2016). Genome Res. 26(4):462-73).Chromatin Immunoprecipitation (ChIP) Analysis: A representative lot detected Lap2alpha in Chromatin Immunoprecipitation applications (Gesson, K., et. al. (2016). Genome Res. 26(4):462-73).Immunoprecipitation Analysis: A representative lot immunoprecipitated Lap2alpha in Immunoprecipitation applications (Gesson, K., et. al. (2016). Genome Res. 26(4):462-73).Immunofluorescence Analysis: A representative lot detected Lap2alpha in Immunofluorescence applications (Gesson, K., et. al. (2016). Genome Res. 26(4):462-73).
Classification
Monoclonal
Form
Purified
Regulatory Status
RUO
Target Species
Mouse
Gene Alias
Lamina-associated polypeptide 2 isoform alpha;Thymopoietin isoforms alpha;TP alpha
Gene Symbols
Tmpo;Lap2
Isotype
IgG2a κ
Purification Method
Protein G purified
Test Specificity
Clone 8C10-1H11 specifically detects Lamina-associated polypeptide 2 alpha (LAP2alpha) in murine species. It targets an epitope in the internal region.
Clone
8C10-1H11
Applications
ChIP Assay, Immunofluorescence, Immunoprecipitation, Western Blot
Conjugate
Unconjugated
Host Species
Mouse
Research Discipline
Inflammation & Immunology
Formulation
Purified mouse monoclonal antibody IgG2a in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene ID (Entrez)
NP_035735
Immunogen
His-tagged recombinant fragment corresponding to 507 amino acids from the C-terminal region.
Primary or Secondary
Primary
Content And Storage
Stable for 1 year at 2-8°C from date of receipt.
Description
- Anti-Lap2alpha, clone 8C10-1H11, Cat
- No
- MABF1997, is a mouse monoclonal antibody that detects Lamina-associated polypeptide 2, isoforms alpha, and has been tested for use in Immunofluorescence, Immunoprecipitation, Chromatin Immunoprecipitation (ChIP), and Western Blotting
- Lamina-associated polypeptide 2, isoforms alpha (UniProt: Q61033; also known as Thymopoietin isoform alpha, TP alpha) is encoded by the Tmpo (also known as Lap2) gene (Gene ID: 21917) in murine species
- LAP2alpha is a non-membrane bound, oligomeric nucleoplasmic protein that associates directly or indirectly with lamins at specific cell-cycle stages
- It is expressed diffusely throughout the nucleus and is involved in the structural organization of the nucleus and in the post-mitotic nuclear assembly
- It is shown to interact with A-type lamins to control gene expression, transcription, and chromatin organization
- The N-terminal part of LAP2alpha contains two structurally independent, non-interacting domains: LEM (LAPEmerin-MAN1)-like domain that binds DNA and a LEM domain that interacts with BANF1
- Its C-terminal domain forms a four-stranded coiled coil
- Lamin A/C and LAP2alpha complexes predominantly co-occur in euchromatic genomic regions and are shown to be highly mobile
- They can bind chromatin in a dynamic manner and are involved in establishing a chromatin environment that is permissive for epigenetic regulation
- Loss of LAP2alpha has been linked to increased proliferation of tissue progenitor cells in epidermis, colon, and the hematopoietic system and delayed skeletal muscle differentiation
- (Res.: Gesson, K et al., (2016)
- Genome Res
- 26(4);462-473).
Compare Similar Items
Show Difference
Antigen: Lap2alpha
Dilution: Western Blotting Analysis: A representative lot detected Lap2alpha in Western Blotting applications (Gesson, K., et. al. (2016). Genome Res. 26(4):462-73).Chromatin Immunoprecipitation (ChIP) Analysis: A representative lot detected Lap2alpha in Chromatin Immunoprecipitation applications (Gesson, K., et. al. (2016). Genome Res. 26(4):462-73).Immunoprecipitation Analysis: A representative lot immunoprecipitated Lap2alpha in Immunoprecipitation applications (Gesson, K., et. al. (2016). Genome Res. 26(4):462-73).Immunofluorescence Analysis: A representative lot detected Lap2alpha in Immunofluorescence applications (Gesson, K., et. al. (2016). Genome Res. 26(4):462-73).
Classification: Monoclonal
Form: Purified
Regulatory Status: RUO
Target Species: Mouse
Gene Alias: Lamina-associated polypeptide 2 isoform alpha;Thymopoietin isoforms alpha;TP alpha
Gene Symbols: Tmpo;Lap2
Isotype: IgG2a κ
Purification Method: Protein G purified
Test Specificity: Clone 8C10-1H11 specifically detects Lamina-associated polypeptide 2 alpha (LAP2alpha) in murine species. It targets an epitope in the internal region.
Clone: 8C10-1H11
Applications: ChIP Assay, Immunofluorescence, Immunoprecipitation, Western Blot
Conjugate: Unconjugated
Host Species: Mouse
Research Discipline: Inflammation & Immunology
Formulation: Purified mouse monoclonal antibody IgG2a in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene ID (Entrez): NP_035735
Immunogen: His-tagged recombinant fragment corresponding to 507 amino acids from the C-terminal region.
Primary or Secondary: Primary
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Antigen:
Lap2alpha
Dilution:
Western Blotting Analysis: A representative lot detected Lap2alpha in Western Blotting applications (Gesson, K., et. al. (2016). Genome Res. 26(4):462-73).Chromatin Immunoprecipitation (ChIP) Analysis: A representative lot detected Lap2alpha in Chromatin Immunoprecipitation applications (Gesson, K., et. al. (2016). Genome Res. 26(4):462-73).Immunoprecipitation Analysis: A representative lot immunoprecipitated Lap2alpha in Immunoprecipitation applications (Gesson, K., et. al. (2016). Genome Res. 26(4):462-73).Immunofluorescence Analysis: A representative lot detected Lap2alpha in Immunofluorescence applications (Gesson, K., et. al. (2016). Genome Res. 26(4):462-73).
Classification:
Monoclonal
Form:
Purified
Regulatory Status:
RUO
Target Species:
Mouse
Gene Alias:
Lamina-associated polypeptide 2 isoform alpha;Thymopoietin isoforms alpha;TP alpha
Gene Symbols:
Tmpo;Lap2
Isotype:
IgG2a κ
Purification Method:
Protein G purified
Test Specificity:
Clone 8C10-1H11 specifically detects Lamina-associated polypeptide 2 alpha (LAP2alpha) in murine species. It targets an epitope in the internal region.
Clone:
8C10-1H11
Applications:
ChIP Assay, Immunofluorescence, Immunoprecipitation, Western Blot
Conjugate:
Unconjugated
Host Species:
Mouse
Research Discipline:
Inflammation & Immunology
Formulation:
Purified mouse monoclonal antibody IgG2a in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene ID (Entrez):
NP_035735
Immunogen:
His-tagged recombinant fragment corresponding to 507 amino acids from the C-terminal region.
Primary or Secondary:
Primary
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.
Antigen: CD11a
Dilution: Flow Cytometry Analysis: A representative lot detected CD11a in Flow Cytometry applications (Baker, M.P., et. al. (1998). Blood. 92(8):2830-43).
Classification: Monoclonal
Form: Purified
Regulatory Status: RUO
Target Species: Human
Gene Alias: Integrin alpha-L;CD11 antigen-like family member A;Leukocyte adhesion glycoprotein LFA-1 alpha chain;LFA-1A;Leukocyte function-associated molecule 1 alpha chain
Gene Symbols: ITGAL;CD11A
Isotype: IgG1 κ
Purification Method: Protein G purified
Test Specificity: Clone BU17 detects CD11a in human cells. It targets an epitope with in the extracellular domain.
Clone: BU17
Applications: Flow Cytometry
Conjugate: Unconjugated
Host Species: Mouse
Research Discipline: Inflammation & Immunology
Formulation: Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene ID (Entrez): NP_002200.2
Immunogen: Waldenstrom macroglobulinemia lymphoplasmacytic cells.
Primary or Secondary: Primary
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Antigen:
CD11a
Dilution:
Flow Cytometry Analysis: A representative lot detected CD11a in Flow Cytometry applications (Baker, M.P., et. al. (1998). Blood. 92(8):2830-43).
Classification:
Monoclonal
Form:
Purified
Regulatory Status:
RUO
Target Species:
Human
Gene Alias:
Integrin alpha-L;CD11 antigen-like family member A;Leukocyte adhesion glycoprotein LFA-1 alpha chain;LFA-1A;Leukocyte function-associated molecule 1 alpha chain
Gene Symbols:
ITGAL;CD11A
Isotype:
IgG1 κ
Purification Method:
Protein G purified
Test Specificity:
Clone BU17 detects CD11a in human cells. It targets an epitope with in the extracellular domain.
Clone:
BU17
Applications:
Flow Cytometry
Conjugate:
Unconjugated
Host Species:
Mouse
Research Discipline:
Inflammation & Immunology
Formulation:
Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene ID (Entrez):
NP_002200.2
Immunogen:
Waldenstrom macroglobulinemia lymphoplasmacytic cells.
Primary or Secondary:
Primary
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.
Antigen: CCR5 (CD195)
Dilution: Immunocytochemistry Analysis: A representative lot detected CCR5 (CD195) in Immunocytochemistry applications (Mueller, A., et. al. (2002). Blood. 99(3):785-91).Flow Cytometry Analysis: A representative lot detected CCR5 (CD195) in Flow Cytometry applications (Mueller, A., et. al. (2002). Blood. 99(3):785-91).
Classification: Monoclonal
Form: Purified
Regulatory Status: RUO
Target Species: Human
Gene Alias: C-C chemokine receptor type 5;C-C CKR-5;CC-CKR-5;CCR-5;CCR5;CHEMR13;HIV-1 fusion coreceptor;CD195
Gene Symbols: CCR5;CMKBR5
Isotype: IgG2b κ
Purification Method: Protein G purified
Test Specificity: Clone HEK/1/85a/7a is a rat monoclonal antibody that specifically detects human C-C-chemokine receptor 5 (CD195).
Clone: HEK/1/85a/7a
Applications: Flow Cytometry, Immunocytochemistry
Conjugate: Unconjugated
Host Species: Rat
Research Discipline: Inflammation & Immunology
Formulation: Purified rat monoclonal antibody IgG2b in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene ID (Entrez): NP_000570.1
Immunogen: CHO cells transfected with full length human CCR-5 (CD195).
Primary or Secondary: Primary
Content And Storage: Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Antigen:
CCR5 (CD195)
Dilution:
Immunocytochemistry Analysis: A representative lot detected CCR5 (CD195) in Immunocytochemistry applications (Mueller, A., et. al. (2002). Blood. 99(3):785-91).Flow Cytometry Analysis: A representative lot detected CCR5 (CD195) in Flow Cytometry applications (Mueller, A., et. al. (2002). Blood. 99(3):785-91).
Classification:
Monoclonal
Form:
Purified
Regulatory Status:
RUO
Target Species:
Human
Gene Alias:
C-C chemokine receptor type 5;C-C CKR-5;CC-CKR-5;CCR-5;CCR5;CHEMR13;HIV-1 fusion coreceptor;CD195
Gene Symbols:
CCR5;CMKBR5
Isotype:
IgG2b κ
Purification Method:
Protein G purified
Test Specificity:
Clone HEK/1/85a/7a is a rat monoclonal antibody that specifically detects human C-C-chemokine receptor 5 (CD195).
Clone:
HEK/1/85a/7a
Applications:
Flow Cytometry, Immunocytochemistry
Conjugate:
Unconjugated
Host Species:
Rat
Research Discipline:
Inflammation & Immunology
Formulation:
Purified rat monoclonal antibody IgG2b in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene ID (Entrez):
NP_000570.1
Immunogen:
CHO cells transfected with full length human CCR-5 (CD195).
Primary or Secondary:
Primary
Content And Storage:
Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Antigen: CCR5 (CD195)
Dilution: Immunocytochemistry Analysis: A representative lot detected CCR5 (CD195) in Immunocytochemistry applications (Mueller, A., et. al. (2002). Blood. 99(3):785-91).Flow Cytometry Analysis: A representative lot detected CCR5 (CD195) in Flow Cytometry applications (Mueller, A., et. al. (2002). Blood. 99(3):785-91).
Classification: Monoclonal
Form: Purified
Regulatory Status: RUO
Target Species: Human
Gene Alias: C-C chemokine receptor type 5;C-C CKR-5;CC-CKR-5;CCR-5;CCR5;CHEMR13;HIV-1 fusion coreceptor;CD195
Gene Symbols: CCR5;CMKBR5
Isotype: IgG2b κ
Purification Method: Protein G purified
Test Specificity: Clone HEK/1/85a/7a is a rat monoclonal antibody that specifically detects human C-C-chemokine receptor 5 (CD195).
Clone: HEK/1/85a/7a
Applications: Flow Cytometry, Immunocytochemistry
Conjugate: Unconjugated
Host Species: Rat
Research Discipline: Inflammation & Immunology
Formulation: Purified rat monoclonal antibody IgG2b in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene ID (Entrez): NP_000570.1
Immunogen: CHO cells transfected with full length human CCR-5 (CD195).
Primary or Secondary: Primary
Content And Storage: Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Antigen:
CCR5 (CD195)
Dilution:
Immunocytochemistry Analysis: A representative lot detected CCR5 (CD195) in Immunocytochemistry applications (Mueller, A., et. al. (2002). Blood. 99(3):785-91).Flow Cytometry Analysis: A representative lot detected CCR5 (CD195) in Flow Cytometry applications (Mueller, A., et. al. (2002). Blood. 99(3):785-91).
Classification:
Monoclonal
Form:
Purified
Regulatory Status:
RUO
Target Species:
Human
Gene Alias:
C-C chemokine receptor type 5;C-C CKR-5;CC-CKR-5;CCR-5;CCR5;CHEMR13;HIV-1 fusion coreceptor;CD195
Gene Symbols:
CCR5;CMKBR5
Isotype:
IgG2b κ
Purification Method:
Protein G purified
Test Specificity:
Clone HEK/1/85a/7a is a rat monoclonal antibody that specifically detects human C-C-chemokine receptor 5 (CD195).
Clone:
HEK/1/85a/7a
Applications:
Flow Cytometry, Immunocytochemistry
Conjugate:
Unconjugated
Host Species:
Rat
Research Discipline:
Inflammation & Immunology
Formulation:
Purified rat monoclonal antibody IgG2b in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene ID (Entrez):
NP_000570.1
Immunogen:
CHO cells transfected with full length human CCR-5 (CD195).
Primary or Secondary:
Primary
Content And Storage:
Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.