7162985
P40 (TP63), Mouse anti-Human, Clone: 11H1, Millipore Sigma™
Mouse Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
P40 (TP63)
Applications
Western Blot
Conjugate
Unconjugated
Host Species
Mouse
Research Discipline
Epigenetics & Nuclear Function
Formulation
Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene ID (Entrez)
NP_001108452
Immunogen
MBP-conjugated recombinant fragment corresponding to the first 205 amino acids from human Tumor protein 63.
Primary or Secondary
Primary
Content And Storage
Stable for 1 year at 2-8°C from date of receipt.
Clone
11H1
Classification
Monoclonal
Form
Purified
Regulatory Status
RUO
Target Species
Human
Gene Alias
Tumor protein 63;p63;Chronic ulcerative stomatitis protein;CUSP;Keratinocyte transcription factor KET;Transformation-related protein 63;TP63;Tumor protein p73-like;p73L;P51
Gene Symbols
P63;KET;P63;P73H;P73L;TP73L
Isotype
IgG1 κ
Purification Method
Protein G purified
Test Specificity
Clone 11H1 detects human Tumor protein 63 (P40). It targets an epitope with in the first 205 amino acids from the N-terminal region.
Description
- Anti-P40 (TP63), clone 11H1, Cat
- No
- MABT1497, is a mouse monoclonal antibody that detects Tumor protein 63 and has been tested for use in Western Blotting
- Tumor protein 63 (UniProt: Q9H3D4; also known as p63, Chronic ulcerative stomatitis protein, CUSP, Keratinocyte transcription factor KET, Transformation-related protein 63, TP63, Tumor protein p73-like, p73L, P40, P51) is encoded by the TP63 (also known as KET, P63, P73H, P73L, TP73L) gene (Gene ID: 8626) in human
- TP63 is a member of the p53 protein family that is widely expressed
- TP63 acts as a sequence specific DNA binding transcriptional activator or repressor
- TP63 is shown to bind to DNA as a homotetramer and its DNA binding region is localized to amino acids 170-362
- It has a transcription activation region (aa 1-107) and a transactivation inhibition region (aa 610-680), which can interact with, and inhibit the activity of the N-terminal transcriptional activation domain of TA-type isoforms
- Twelve different isoforms of TP63 have been described that are produced by alternative promoter usage and alternative splicing
- These isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity
- The ratio of DeltaN-type and TA-type isoforms governs the maintenance of epithelial stem cell compartments and regulates the initiation of epithelial stratification from the undifferentiated embryonal ectoderm
- Isoform 2 is reported to activate RIPK4 transcription and may be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes
- Isoform 10 is predominantly expressed in skin squamous cell carcinoma, but not in normal skin tissue.
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Antigen: P40 (TP63)
Applications: Western Blot
Conjugate: Unconjugated
Host Species: Mouse
Research Discipline: Epigenetics & Nuclear Function
Formulation: Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene ID (Entrez): NP_001108452
Immunogen: MBP-conjugated recombinant fragment corresponding to the first 205 amino acids from human Tumor protein 63.
Primary or Secondary: Primary
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Clone: 11H1
Classification: Monoclonal
Form: Purified
Regulatory Status: RUO
Target Species: Human
Gene Alias: Tumor protein 63;p63;Chronic ulcerative stomatitis protein;CUSP;Keratinocyte transcription factor KET;Transformation-related protein 63;TP63;Tumor protein p73-like;p73L;P51
Gene Symbols: P63;KET;P63;P73H;P73L;TP73L
Isotype: IgG1 κ
Purification Method: Protein G purified
Test Specificity: Clone 11H1 detects human Tumor protein 63 (P40). It targets an epitope with in the first 205 amino acids from the N-terminal region.
Antigen:
P40 (TP63)
Applications:
Western Blot
Conjugate:
Unconjugated
Host Species:
Mouse
Research Discipline:
Epigenetics & Nuclear Function
Formulation:
Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene ID (Entrez):
NP_001108452
Immunogen:
MBP-conjugated recombinant fragment corresponding to the first 205 amino acids from human Tumor protein 63.
Primary or Secondary:
Primary
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.
Clone:
11H1
Classification:
Monoclonal
Form:
Purified
Regulatory Status:
RUO
Target Species:
Human
Gene Alias:
Tumor protein 63;p63;Chronic ulcerative stomatitis protein;CUSP;Keratinocyte transcription factor KET;Transformation-related protein 63;TP63;Tumor protein p73-like;p73L;P51
Gene Symbols:
P63;KET;P63;P73H;P73L;TP73L
Isotype:
IgG1 κ
Purification Method:
Protein G purified
Test Specificity:
Clone 11H1 detects human Tumor protein 63 (P40). It targets an epitope with in the first 205 amino acids from the N-terminal region.
Antigen: phospho-cytokeratin-8 (K8) (Ser431)
Applications: Immunofluorescence, Western Blot
Conjugate: Unconjugated
Host Species: Mouse
Research Discipline: Cell Structure
Formulation: Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene ID (Entrez): NP_001243222
Immunogen: Cytokeratin-8/18 purified from okadaic acid-treated HT29 cells.
Primary or Secondary: Primary
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Clone: 5B3
Classification: Monoclonal
Form: Purified
Regulatory Status: RUO
Target Species: Human, Mouse
Gene Alias: Keratin;type II cytoskeletal 8;CK-8;Keratin-8;K8;Type-II keratin Kb80
Gene Symbols: KRT8;CYK8
Isotype: IgG1 κ
Purification Method: Protein G purified
Test Specificity: Clone 5B3 specifically detects cytokeratin-8 phosphorylated on serine 431.
Antigen:
phospho-cytokeratin-8 (K8) (Ser431)
Applications:
Immunofluorescence, Western Blot
Conjugate:
Unconjugated
Host Species:
Mouse
Research Discipline:
Cell Structure
Formulation:
Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene ID (Entrez):
NP_001243222
Immunogen:
Cytokeratin-8/18 purified from okadaic acid-treated HT29 cells.
Primary or Secondary:
Primary
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.
Clone:
5B3
Classification:
Monoclonal
Form:
Purified
Regulatory Status:
RUO
Target Species:
Human, Mouse
Gene Alias:
Keratin;type II cytoskeletal 8;CK-8;Keratin-8;K8;Type-II keratin Kb80
Gene Symbols:
KRT8;CYK8
Isotype:
IgG1 κ
Purification Method:
Protein G purified
Test Specificity:
Clone 5B3 specifically detects cytokeratin-8 phosphorylated on serine 431.
Antigen: phospho-cytokeratin-8 (K8) (Ser73)
Applications: ELISA, Immunocytochemistry, Immunofluorescence
Conjugate: Unconjugated
Host Species: Mouse
Research Discipline: Cell Structure
Formulation: Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene ID (Entrez): NP_001243222
Immunogen: Cytokeratin-8 purified from HT29 cells treated with okadaic acid (1 mg/ml, 2h).
Primary or Secondary: Primary
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Clone: LJ4
Classification: Monoclonal
Form: Purified
Regulatory Status: RUO
Target Species: Mouse, Human
Gene Alias: Keratin;type II cytoskeletal 8;CK-8;Keratin-8;K8;Type-II keratin Kb80
Gene Symbols: KRT8;CYK8
Isotype: IgG1 κ
Purification Method: Protein G purified
Test Specificity: Clone LJ4 detects human cytokeratin-8 phosphorylated on serine 73 and murine cytokeratin-8 phosphorylated on serine 79.
Antigen:
phospho-cytokeratin-8 (K8) (Ser73)
Applications:
ELISA, Immunocytochemistry, Immunofluorescence
Conjugate:
Unconjugated
Host Species:
Mouse
Research Discipline:
Cell Structure
Formulation:
Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene ID (Entrez):
NP_001243222
Immunogen:
Cytokeratin-8 purified from HT29 cells treated with okadaic acid (1 mg/ml, 2h).
Primary or Secondary:
Primary
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.
Clone:
LJ4
Classification:
Monoclonal
Form:
Purified
Regulatory Status:
RUO
Target Species:
Mouse, Human
Gene Alias:
Keratin;type II cytoskeletal 8;CK-8;Keratin-8;K8;Type-II keratin Kb80
Gene Symbols:
KRT8;CYK8
Isotype:
IgG1 κ
Purification Method:
Protein G purified
Test Specificity:
Clone LJ4 detects human cytokeratin-8 phosphorylated on serine 73 and murine cytokeratin-8 phosphorylated on serine 79.
Antigen: phospho-cytokeratin-18 (K18) (Ser33)
Applications: Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Western Blot
Conjugate: Unconjugated
Host Species: Mouse
Research Discipline: Cell Structure
Formulation: Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene ID (Entrez): NP_000215
Immunogen: KLH-conjugated linear peptide corresponding to 13 amino acids surrounding phosphorylated serine 33 (initiator methionine removed) from the N-terminal region of human cytokeratin-18.
Primary or Secondary: Primary
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Clone: IB4
Classification: Monoclonal
Form: Purified
Regulatory Status: RUO
Target Species: Human
Gene Alias: Keratin type I cytoskeletal 18;Cell proliferation-inducing gene 46 protein;CK-18;Keratin-18;K18
Gene Symbols: KRT18;CYK18;PIG46
Isotype: IgG1 κ
Purification Method: Protein G purified
Test Specificity: Clone IB4 specifically detects human cytokeratin-18 phosphorylated on serine 33.
Antigen:
phospho-cytokeratin-18 (K18) (Ser33)
Applications:
Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Western Blot
Conjugate:
Unconjugated
Host Species:
Mouse
Research Discipline:
Cell Structure
Formulation:
Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene ID (Entrez):
NP_000215
Immunogen:
KLH-conjugated linear peptide corresponding to 13 amino acids surrounding phosphorylated serine 33 (initiator methionine removed) from the N-terminal region of human cytokeratin-18.
Primary or Secondary:
Primary
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.
Clone:
IB4
Classification:
Monoclonal
Form:
Purified
Regulatory Status:
RUO
Target Species:
Human
Gene Alias:
Keratin type I cytoskeletal 18;Cell proliferation-inducing gene 46 protein;CK-18;Keratin-18;K18
Gene Symbols:
KRT18;CYK18;PIG46
Isotype:
IgG1 κ
Purification Method:
Protein G purified
Test Specificity:
Clone IB4 specifically detects human cytokeratin-18 phosphorylated on serine 33.