Mouse Monoclonal Antibody
Manufacturer: Fischer Scientific
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Emerin
0.2 mg/mL
Western Blot, Immunohistochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Peptide Array
Unconjugated
Mouse
Human
P50402
2010
Recombinant human Emerin protein fragment (around aa 56-167) (exact sequence is proprietary)
Primary
Store at 4°C.
EMD/2167
Western Blot 1-2 ug/ml, Immunohistochemistry 1-2 ug/ml, Immunocytochemistry/Immunofluorescence 1-3 ug/ml, Immunohistochemistry-Paraffin 1-2 ug/ml, Protein Array
Monoclonal
Purified
RUO
10 mM PBS with 0.05% BSA
emerin, Emery-Dreifuss muscular dystrophy, LEM domain containing 5, STAEDMDLEMD5
EMD
IgG1 κ
Protein A or G purified
Emerin is a member of the nuclear lamina associated protein family. It is ubiquitously expressed and localized to the nuclear membrane in normal cells. Mutations of the gene that encodes emerin result in the X-linked recessive disease Emery-Dreifuss muscular dystrophy (EDMD), which is characterized by slowly progressing contractures, skeletal muscle wasting and cardiomyopathy. Reportedly, lack of Emerin expression is one cause of EDMD. Emerin is involved in the association of the nuclear membrane with the lamina, and is localized specifically to desmosomes and fasciae adherents in the heart. Identification of nuclear membrane irregularities with anti-emerin antibody has been reported useful in diagnosing papillary thyroid carcinoma.