7188649
FOXO1/FKHR Polyclonal Antibody, Active Motif™
Rabbit Polyclonal Antibody
Manufacturer: Fischer Scientific
The price for this product is unavailable. Please request a quote
Antigen
FOXO1/FKHR
Applications
Immunoprecipitation, Western Blot
Conjugate
Unconjugated
Host Species
Rabbit
Target Species
Human
Gene Accession No.
Q12778
Gene ID (Entrez)
2308
Immunogen
This FOXO1/FkHR antibody was raised against a peptide from the C-terminal region of human FOXO1/FkHR.
Primary or Secondary
Primary
Content And Storage
-20°C, Avoid Freeze/Thaw Cycles
Gene
FOXO1
Concentration
Lot-Specific
Classification
Polyclonal
Form
Liquid
Regulatory Status
RUO
Formulation
70mM tris with 0.07mM EDTA, 105mM NaCl, 30% glycerol, 31mM glycine and 0.035% sodium azide; pH 8
Gene Alias
Afxh; AI876417; FKH1; FKHR; Fkhr1; forkhead box O1; forkhead box O1 a; forkhead box O1a; forkhead box O1A (rhabdomyosarcoma); Forkhead box protein O1; Forkhead box protein O1A; Forkhead box protein O1-A; Forkhead in rhabdomyosarcoma; forkhead protein 1; forkhead, Drosophila, homolog of, in rhabdomyosarcoma; fox family transcription factor FoxO1a.1; FOX01A; foxhead box protein O1-A; Foxo1; Foxo1a; foxO1a.1; zgc:153388
Gene Symbols
FOXO1
Isotype
IgG
Purification Method
Antigen affinity chromatography
Product Type
Antibody
Related Products
Description
- FOXO1 (FKHR, ForKHead Box 01) is a member in a subfamily of the forkhead homeotic gene family of transcription factors
- Recent experiments have shown that FOXO1 can act as either a coactivator or a corepressor of nuclear receptor activity that is mediated through the LXXLL motif found in the carboxyl terminal region of the FKHR protein
- Association of FOXO1 with PAX3 has been implicated in alveolar rhabdomyosarcoma
- Recent studies link the anti-tumor activity of FOXO1, the process of autophagy and myogenic growth and differentiation
- FOXO1 is the main target of insulin signaling that regulated the metabolic homeostasis in response to oxidative stress
- FOXO1 binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'- TT[G/A]TTTAC-3'
- FOXO1 is a regulator of redox balance, osteoblast numbers and controls bone mass
- Further, FOXO1 orchestrates the endocrine function of the skeleton in regulating glucose metabolism, and suppresses the transcriptional activity of RUNX2, an upstream activator of osteocalcin/BGLAP
- In hepatocytes, FOXO1 promotes gluconeogenesis by acting together with PPARGC1A to activate the expression of genes such as IGFBP1, G6PC and PPCK1
- FOXO1 is an important regulator of cell death acting downstream of CDK1, PKB/AKT1 and SKT4/MST1.
Compare Similar Items
Show Difference
Antigen: FOXO1/FKHR
Applications: Immunoprecipitation, Western Blot
Conjugate: Unconjugated
Host Species: Rabbit
Target Species: Human
Gene Accession No.: Q12778
Gene ID (Entrez): 2308
Immunogen: This FOXO1/FkHR antibody was raised against a peptide from the C-terminal region of human FOXO1/FkHR.
Primary or Secondary: Primary
Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
Gene: FOXO1
Concentration: Lot-Specific
Classification: Polyclonal
Form: Liquid
Regulatory Status: RUO
Formulation: 70mM tris with 0.07mM EDTA, 105mM NaCl, 30% glycerol, 31mM glycine and 0.035% sodium azide; pH 8
Gene Alias: Afxh; AI876417; FKH1; FKHR; Fkhr1; forkhead box O1; forkhead box O1 a; forkhead box O1a; forkhead box O1A (rhabdomyosarcoma); Forkhead box protein O1; Forkhead box protein O1A; Forkhead box protein O1-A; Forkhead in rhabdomyosarcoma; forkhead protein 1; forkhead, Drosophila, homolog of, in rhabdomyosarcoma; fox family transcription factor FoxO1a.1; FOX01A; foxhead box protein O1-A; Foxo1; Foxo1a; foxO1a.1; zgc:153388
Gene Symbols: FOXO1
Isotype: IgG
Purification Method: Antigen affinity chromatography
Product Type: Antibody
Antigen:
FOXO1/FKHR
Applications:
Immunoprecipitation, Western Blot
Conjugate:
Unconjugated
Host Species:
Rabbit
Target Species:
Human
Gene Accession No.:
Q12778
Gene ID (Entrez):
2308
Immunogen:
This FOXO1/FkHR antibody was raised against a peptide from the C-terminal region of human FOXO1/FkHR.
Primary or Secondary:
Primary
Content And Storage:
-20°C, Avoid Freeze/Thaw Cycles
Gene:
FOXO1
Concentration:
Lot-Specific
Classification:
Polyclonal
Form:
Liquid
Regulatory Status:
RUO
Formulation:
70mM tris with 0.07mM EDTA, 105mM NaCl, 30% glycerol, 31mM glycine and 0.035% sodium azide; pH 8
Gene Alias:
Afxh; AI876417; FKH1; FKHR; Fkhr1; forkhead box O1; forkhead box O1 a; forkhead box O1a; forkhead box O1A (rhabdomyosarcoma); Forkhead box protein O1; Forkhead box protein O1A; Forkhead box protein O1-A; Forkhead in rhabdomyosarcoma; forkhead protein 1; forkhead, Drosophila, homolog of, in rhabdomyosarcoma; fox family transcription factor FoxO1a.1; FOX01A; foxhead box protein O1-A; Foxo1; Foxo1a; foxO1a.1; zgc:153388
Gene Symbols:
FOXO1
Isotype:
IgG
Purification Method:
Antigen affinity chromatography
Product Type:
Antibody
Antigen: Mi-2
Applications: Immunofluorescence, Immunoprecipitation, Western Blot
Conjugate: Unconjugated
Host Species: Rat
Target Species: Drosophila
Gene Accession No.: __
Gene ID (Entrez): __
Immunogen: This antibody was raised against a synthetic peptide corresponding to amino acid residues 1641-1662 of Drosophila Mi-2.
Primary or Secondary: Primary
Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
Gene: __
Concentration: 1 mg/mL
Classification: Monoclonal
Form: Liquid
Regulatory Status: RUO
Formulation: PBS with 30% glycerol and 0.035% sodium azide; pH 7.5
Gene Alias: 9530019N15Rik; AA617397; ATP-dependent helicase CHD4; BC005710; CHD4; CHD-4; chromodomain helicase DNA binding protein 4; Chromodomain-helicase-DNA-binding protein 4; D6Ertd380e; Mi-2; Mi-2 autoantigen; Mi-2 autoantigen 218 kDa protein; Mi-2 beta; MI2B; Mi-2b; Mi-2beta; Mi2-beta; mKIAA4075
Gene Symbols: __
Isotype: IgG2c
Purification Method: Protein G
Product Type: Antibody
Antigen:
Mi-2
Applications:
Immunofluorescence, Immunoprecipitation, Western Blot
Conjugate:
Unconjugated
Host Species:
Rat
Target Species:
Drosophila
Gene Accession No.:
__
Gene ID (Entrez):
__
Immunogen:
This antibody was raised against a synthetic peptide corresponding to amino acid residues 1641-1662 of Drosophila Mi-2.
Primary or Secondary:
Primary
Content And Storage:
-20°C, Avoid Freeze/Thaw Cycles
Gene:
__
Concentration:
1 mg/mL
Classification:
Monoclonal
Form:
Liquid
Regulatory Status:
RUO
Formulation:
PBS with 30% glycerol and 0.035% sodium azide; pH 7.5
Gene Alias:
9530019N15Rik; AA617397; ATP-dependent helicase CHD4; BC005710; CHD4; CHD-4; chromodomain helicase DNA binding protein 4; Chromodomain-helicase-DNA-binding protein 4; D6Ertd380e; Mi-2; Mi-2 autoantigen; Mi-2 autoantigen 218 kDa protein; Mi-2 beta; MI2B; Mi-2b; Mi-2beta; Mi2-beta; mKIAA4075
Gene Symbols:
__
Isotype:
IgG2c
Purification Method:
Protein G
Product Type:
Antibody
Antigen: Histone H3ac (pan-acetyl)
Applications: __
Conjugate: Unconjugated
Host Species: Rabbit
Target Species: Human
Gene Accession No.: __
Gene ID (Entrez): __
Immunogen: This antibody was raised against a peptide including acetyl-lysines contained in the N-terminal tail of human Histone H3.
Primary or Secondary: Primary
Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
Gene: __
Concentration: Lot-Specific
Classification: Polyclonal
Form: Liquid
Regulatory Status: RUO
Formulation: PBS with 30% glycerol and 0.035% sodium azide; pH 7.5
Gene Alias: __
Gene Symbols: __
Isotype: IgG
Purification Method: Protein A
Product Type: Antibody
Antigen:
Histone H3ac (pan-acetyl)
Applications:
__
Conjugate:
Unconjugated
Host Species:
Rabbit
Target Species:
Human
Gene Accession No.:
__
Gene ID (Entrez):
__
Immunogen:
This antibody was raised against a peptide including acetyl-lysines contained in the N-terminal tail of human Histone H3.
Primary or Secondary:
Primary
Content And Storage:
-20°C, Avoid Freeze/Thaw Cycles
Gene:
__
Concentration:
Lot-Specific
Classification:
Polyclonal
Form:
Liquid
Regulatory Status:
RUO
Formulation:
PBS with 30% glycerol and 0.035% sodium azide; pH 7.5
Gene Alias:
__
Gene Symbols:
__
Isotype:
IgG
Purification Method:
Protein A
Product Type:
Antibody
Antigen: Histone H3ac (pan-acetyl)
Applications: __
Conjugate: Unconjugated
Host Species: Rabbit
Target Species: Human
Gene Accession No.: __
Gene ID (Entrez): __
Immunogen: This antibody was raised against a peptide including acetyl-lysines contained in the N-terminal tail of human Histone H3.
Primary or Secondary: Primary
Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
Gene: __
Concentration: Lot-Specific
Classification: Polyclonal
Form: Liquid
Regulatory Status: RUO
Formulation: PBS with 30% glycerol and 0.035% sodium azide; pH 7.5
Gene Alias: __
Gene Symbols: __
Isotype: IgG
Purification Method: Protein A
Product Type: Antibody
Antigen:
Histone H3ac (pan-acetyl)
Applications:
__
Conjugate:
Unconjugated
Host Species:
Rabbit
Target Species:
Human
Gene Accession No.:
__
Gene ID (Entrez):
__
Immunogen:
This antibody was raised against a peptide including acetyl-lysines contained in the N-terminal tail of human Histone H3.
Primary or Secondary:
Primary
Content And Storage:
-20°C, Avoid Freeze/Thaw Cycles
Gene:
__
Concentration:
Lot-Specific
Classification:
Polyclonal
Form:
Liquid
Regulatory Status:
RUO
Formulation:
PBS with 30% glycerol and 0.035% sodium azide; pH 7.5
Gene Alias:
__
Gene Symbols:
__
Isotype:
IgG
Purification Method:
Protein A
Product Type:
Antibody