Collagen Type III Polyclonal Antibody, Rockland™

Description

• Store vial at 4°C prior to opening
• This product is stable at 4°C as an undiluted liquid
• Dilute only prior to immediate use
• For extended storage, mix with an equal volume of glycerol, aliquot contents and freeze at -20°C or below
• Avoid cycles of freezing and thawing
• Typically negligible cross-reactivity against other types of collagens was detected by ELISA against purified standards
• Some class-specific anti-collagens may be specific for three-dimensional epitopes which may result in diminished reactivity with denatured collagen or formalin-fixed, paraffin embedded tissues
• This antibody reacts with most mammalian Type III collagens and has negligible cross-reactivity with Type I, II, IV, V or VI collagens
• Non-specific cross-reaction of anti-collagen antibodies with other human serum proteins or non-collagen extracellular matrix proteins is negligible
• Collagen III is a fibrillar collagen that is found in extensible connective tissues such as skin, lung, and the vascular system, frequently in association with type I Collagen
• Mutations in th gene are associated with Ehlers Danlos syndrome type IV , and with aortic and arterial aneurysms
• Although alternate transcripts have been detected for this gene, they are the result of mutations; these mutations alter splicing, often leading to the exclusion of multiple exons.