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7215129

Phospho-Jak2 (Tyr1007, Tyr1008) Recombinant Rabbit Monoclonal Antibody (JAK2Y10071008-PB6), APC, Invitrogen™

Rabbit Recombinant Monoclonal Antibody

Manufacturer: Fischer Scientific

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Antigen

Phospho-Jak2 (Tyr1007, Tyr1008)

Applications

Flow Cytometry

Conjugate

APC

Host Species

Rabbit

Target Species

Human

Gene Accession No.

O60674

Gene ID (Entrez)

3717

Immunogen

A synthetic phospho-peptide corresponding to residues surrounding Tyr1007/Tyr1008 of human phospho Jak2.

Primary or Secondary

Primary

Content And Storage

4° C

Gene

JAK2

Clone

JAK2Y10071008-PB6

Classification

Monoclonal

Form

Liquid

Regulatory Status

RUO

Formulation

PBS with 0.20% BSA and 0.09% sodium azide

Gene Alias

EC 2.7.10.2; Fd17; JAK 2; JAK2; JAK-2; Janus kinase 2; Janus kinase 2 (a protein tyrosine kinase); JTK 10; JTK10; kinase Jak2; THCYT3; Tyrosine-protein kinase JAK2

Gene Symbols

JAK2

Isotype

IgG κ

Purification Method

Protein A/G

Product Type

Antibody

Description

  • Janus kinase 2 (JAK2) is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways and is mutated in polycythemia vera
  • This kinase contains the catalytic domain (JH1) of JAK2
  • The activation of JAKs can lead to the phosphorylation of STAT (signal transducers and activatiors of transcription) proteins, which dimerize and translocate to the nucleus
  • Once translocated to the nucleus, the STAT proteins can modify transcription of numerous genes, including interferon-stimulated genes
  • JAK2 is required for the IFN gamma-receptor complex initiation and JAK1 functions as an amplifier
  • Some studies have suggested that the role of JAK2 might be performed by Tyk2 and JAK3, if they were positioned correctly within the IFN gamma-receptor complex
  • Mutations affecting JAK2 can cause Budd-Chiari syndrome, Polycythemia vera, Thrombocythemia 3, myelofibrosis, or Acute myelogenous leukemia.

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Fischer Scientific

7215129

Rabbit Recombinant Monoclonal Antib...

Antigen:
Phospho-Jak2 (Tyr1007, Tyr1008)
Applications:
Flow Cytometry
Conjugate:
APC
Host Species:
Rabbit
Target Species:
Human
Gene Accession No.:
O60674
Gene ID (Entrez):
3717
Immunogen:
A synthetic phospho-peptide corresponding to residues surrounding Tyr1007/Tyr1008 of human phospho Jak2.
Primary or Secondary:
Primary
Content And Storage:
4° C
Gene:
JAK2
Clone:
JAK2Y10071008-PB6
Classification:
Monoclonal
Form:
Liquid
Regulatory Status:
RUO
Formulation:
PBS with 0.20% BSA and 0.09% sodium azide
Gene Alias:
EC 2.7.10.2; Fd17; JAK 2; JAK2; JAK-2; Janus kinase 2; Janus kinase 2 (a protein tyrosine kinase); JTK 10; JTK10; kinase Jak2; THCYT3; Tyrosine-protein kinase JAK2
Gene Symbols:
JAK2
Isotype:
IgG κ
Purification Method:
Protein A/G
Product Type:
Antibody

Img

Fischer Scientific

7215130

Rabbit Recombinant Monoclonal Antib...

Antigen:
SARS-CoV-2 Nucleocapsid
Applications:
ELISA
Conjugate:
Unconjugated
Host Species:
Rabbit
Target Species:
Virus
Gene Accession No.:
P0DTC9
Gene ID (Entrez):
43740575
Immunogen:
SARS-CoV-2 nucleoprotein (NP) specific peptide.
Primary or Secondary:
Primary
Content And Storage:
4° C
Gene:
N
Clone:
84D7
Classification:
Monoclonal
Form:
Liquid
Regulatory Status:
RUO
Formulation:
PBS with 0.02% sodium azide
Gene Alias:
COVID19 Nucleocapsid, COVID-19 nucleocapsid, COVID19 Spike nucleocapsid, SARS-CoV-2 N
Gene Symbols:
N
Isotype:
IgG κ
Purification Method:
Protein A
Product Type:
Antibody

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7215131

Rabbit Recombinant Monoclonal Antib...

Antigen:
Phospho-Shp2 (Tyr580)
Applications:
Flow Cytometry
Conjugate:
APC
Host Species:
Rabbit
Target Species:
Human, Mouse
Gene Accession No.:
P35235, Q06124
Gene ID (Entrez):
19247, 5781
Immunogen:
A synthetic phospho-peptide corresponding to residues surrounding Tyr580 of human phospho Shp2.
Primary or Secondary:
Primary
Content And Storage:
4° C
Gene:
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Clone:
Shp2Y580-4A2
Classification:
Monoclonal
Form:
Liquid
Regulatory Status:
RUO
Formulation:
PBS with 0.20% BSA and 0.09% sodium azide
Gene Alias:
2700084A17Rik; AW536184; bptp3; CFC; cSH-PTP2; encodes catalytic domain; HCP; HGNC:9644; JMML; METCDS; MGC14433; Noonan syndrome 1; ns1; null; OTTHUMP00000166108; phosphotyrosyl-protein phosphatase; protein tyrosine phosphatase non-receptor type 11; protein tyrosine phosphatase SH-PTP2; protein tyrosine phosphatase, non-receptor type 11; protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1); protein tyrosine phosphatase, non-receptor type 11 S homeolog; protein-tyrosine phosphatase 1D; Protein-tyrosine phosphatase 2C; protein-tyrosine phosphatase SYP; PTP1C; PTP1D; PTP-1D; ptp-2; PTP2C; PTP-2C; Ptpn11; ptpn11.S; ptpn11-a; ptpn11-b; SAP-2; SH2 domain-containing protein tyrosine phosphatase-2; Shp2; shp-2; SHPTP2; SH-PTP2; SH-PTP2 protein tyrosine phosphatase non-receptor type 11; SH-PTP2 protein tyrosine phosphatase, non-receptor type 11; SH-PTP3; Syp; Tyrosine-protein phosphatase non-receptor type 11; XELAEV_18010676mg
Gene Symbols:
PTPN11
Isotype:
IgG κ
Purification Method:
Protein A/G
Product Type:
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Fischer Scientific

7215134

Rabbit Recombinant Monoclonal Antib...

Antigen:
Phospho-Jak2 (Tyr1007, Tyr1008)
Applications:
Flow Cytometry
Conjugate:
Unconjugated
Host Species:
Rabbit
Target Species:
Human
Gene Accession No.:
O60674
Gene ID (Entrez):
3717
Immunogen:
A synthetic phospho-peptide corresponding to residues surrounding Tyr1007/Tyr1008 of human phospho Jak2.
Primary or Secondary:
Primary
Content And Storage:
-20°C
Gene:
JAK2
Clone:
Jak2Y10071008-PB6
Classification:
Monoclonal
Form:
Liquid
Regulatory Status:
RUO
Formulation:
PBS with 0.10% BSA, 50% glycerol and 0.02% sodium azide
Gene Alias:
EC 2.7.10.2; Fd17; JAK 2; JAK2; JAK-2; Janus kinase 2; Janus kinase 2 (a protein tyrosine kinase); JTK 10; JTK10; kinase Jak2; THCYT3; Tyrosine-protein kinase JAK2
Gene Symbols:
JAK2
Isotype:
IgG κ
Purification Method:
Protein A/G
Product Type:
Antibody