7218440

Angiogenin Monoclonal Antibody (26-2F), eBioscience™, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer: Fischer Scientific

The price for this product is unavailable. Please request a quote

Antigen

Angiogenin

Concentration

0.5 mg/mL

Conjugate

Unconjugated

Host Species

Mouse

Target Species

Human

Gene Accession No.

P03950

Isotype

IgG1 κ

Purification Method

Affinity chromatography

Product Type

Antibody

Clone

26-2F

Classification

Monoclonal

Form

Liquid

Regulatory Status

RUO

Formulation

PBS with 0.09% sodium azide; pH 7.2

Gene ID (Entrez)

283

Primary or Secondary

Primary

Content And Storage

4° C

Gene

ANG

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Description

  • The MAb 26-2F recognizes human angiogenin
  • Angiogenin is a secreted ribonuclease (RNASE)-family member and is important for the formation of new blood vessels as well as the stimulation of cell proliferation and survival
  • Cellular stress signals direct angiogenin to stress granules where angiogenin functions by hydrolyzing cellular tRNA resulting in modulation of protein translation and promotion of cell survival
  • Cytoplasmic angiogenin can bind to actin, forming complexes that activate protease cascades which can degrade laminin and fibronectin allowing endothelial cells to penetrate the basement membrane and migrate
  • In cancer cells, growth signals direct angiogenin translocation to the nucleus where binding of DNA promotor regions stimulates rRNA transcription resulting in a downstream increase in protein synthesis driving cell growth and survival
  • Angiogenin is upregulated in multiple cancers including breast, prostate, cervical, colorectal, lymphoma, and melanoma
  • During development and in adulthood, angiogenin is highly expressed in the spinal cord and contributes to motor neuron survival
  • Angiogenin is important for neuronal survival and is depleted in neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and Parkinson's disease
  • This 26-2F antibody is reported to have both in vivo and in vitro neutralizing activity to angiogenin
  • Angiogenin (ANG or ANG I) is important for the process of neovascularization and formation of new blood vessels
  • ANG is similar to pancreatic ribonuclease A and functions as a tRNA-specific ribonuclease that abolishes protein synthesis by specifically hydrolyzing cellular tRNAs
  • It interacts with endothelial cell-surface actin and may cause changes in the cell cytoskeleton
  • ANG is thought to be involved in the development of solid tumors and its antagonists are capable of inhibiting tumor growth
  • Defects in ANG are the cause of susceptibility to amyotrophic lateral sclerosis type 9 (ALS9)
  • Angiogenin is a genetic link between ALS and PD.

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Show Difference

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Fischer Scientific

7218440

Mouse Monoclonal Antibody...


Antigen:
Angiogenin

Concentration:
0.5 mg/mL

Conjugate:
Unconjugated

Host Species:
Mouse

Target Species:
Human

Gene Accession No.:
P03950

Isotype:
IgG1 κ

Purification Method:
Affinity chromatography

Product Type:
Antibody

Clone:
26-2F

Classification:
Monoclonal

Form:
Liquid

Regulatory Status:
RUO

Formulation:
PBS with 0.09% sodium azide; pH 7.2

Gene ID (Entrez):
283

Primary or Secondary:
Primary

Content And Storage:
4° C

Gene:
ANG

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7218444

Rat Monoclonal Antibody...


Antigen:
F4/80

Concentration:
0.2 mg/mL

Conjugate:
Alexa Fluor 561

Host Species:
Rat

Target Species:
Mouse

Gene Accession No.:
Q61549

Isotype:
IgG2a κ

Purification Method:
Affinity chromatography

Product Type:
Antibody

Clone:
BM8

Classification:
Monoclonal

Form:
Liquid

Regulatory Status:
RUO

Formulation:
PBS with 0.09% sodium azide; pH 7.2

Gene ID (Entrez):
13733

Primary or Secondary:
Primary

Content And Storage:
4° C, store in dark, DO NOT FREEZE!

Gene:
ADGRE1

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Antigen:
beta-3 Tubulin

Concentration:
0.5 mg/mL

Conjugate:
Unconjugated

Host Species:
Mouse

Target Species:
Bovine, Human, Mouse, Rat

Gene Accession No.:
Q13509, Q2T9S0, Q4QRB4, Q9ERD7

Isotype:
IgG2a κ

Purification Method:
Affinity chromatography

Product Type:
Antibody

Clone:
2G10-TB3

Classification:
Monoclonal

Form:
Liquid

Regulatory Status:
RUO

Formulation:
PBS with 0.09% sodium azide; pH 7.2

Gene ID (Entrez):
10381, 22152, 246118, 768070

Primary or Secondary:
Primary

Content And Storage:
4° C

Gene:
TUBB3

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Antigen:
Phospho-STAT1 (Tyr701)

Concentration:
0.5 mg/mL

Conjugate:
Unconjugated

Host Species:
Mouse

Target Species:
Human

Gene Accession No.:
P42224

Isotype:
IgG1 κ

Purification Method:
Affinity chromatography

Product Type:
Antibody

Clone:
KIKSI0803

Classification:
Monoclonal

Form:
Liquid

Regulatory Status:
RUO

Formulation:
PBS with 0.09% sodium azide; pH 7.2

Gene ID (Entrez):
6772

Primary or Secondary:
Primary

Content And Storage:
4° C

Gene:
STAT1