BD Horizon™ CD105 Mouse, anti-Human, RY586, Clone: 266, BD Horizon™

Description

• The 266 monoclonal antibody specifically binds to CD105
• CD105 is a type I transmembrane glycoprotein that is encoded by END (Endoglin) and belongs to the transforming growth factor-β (TGF-β) type III receptor family
• CD105 is expressed on cells as a homodimer comprised of ∼95 kDa subunits
• CD105 is expressed on vascular endothelial cells and placental syncytiotrophoblasts and at lower levels on stromal fibroblasts
• It is also expressed on mesenchymal stem cells, erythroid precursors, activated macrophages, pre-B cells, and some tumor cells and cell lines including U937 cells
• CD105 serves as a regulatory component of the TGF-β receptor system
• In association with TGF- βRI or TGF- βRII, CD105 binds TGF-β1 and TGF-β3 with high affinity but does not bind to TGF-β2
• Expression of CD105 is increased on activated endothelium in tissues undergoing angiogenesis, such as in tumors, or in cases of wound healing or dermal inflammation.