BD Horizon™ IFN-γ Mouse, anti-Human, RY586, Clone: B27, BD Horizon™

Description

• The B27 monoclonal antibody specifically binds to human interferon-γ (IFN-γ), a 14-18 kDa glycoprotein containing 143 amino acid residues.  IFN-γ is a potent multifunctional cytokine produced by several activated cell types including NK, NKT, CD4+TCRαβ+, CD8+TCRαβ+, and TCRγδ+ T cells
• IFN-γ exerts its biological effects through specific binding to the high-affinity IFN-γ receptor complex comprised of IFN-γRα (CD119) and IFN-γRβ subunits
• In addition to its antiviral effects, IFN-γ upregulates a number of lymphoid cell functions including the antimicrobial and anti-tumor responses of macrophages, NK cells, and neutrophils
• In addition, IFN-γ influences the regulation of proliferation, differentiation, and effector responses of B cell and T cell subsets
• These influences can involve IFN-γ's capacity to boost MHC class I and II expression by antigen-presenting cells as well as direct effects on B cells and T cells themselves
• B27 is a neutralizing antibody
• The use of B27 antibody for epitope mapping of human IFN-γ has been described
• The B27 antibody has been reported not to bind to denatured IFN-γ.