BD Horizon™ Zbtb7b Rat, anti-Mouse, RY586, Clone: T43-94, BD Horizon™

Description

• The T43-94 monoclonal antibody specifically recognizes mouse Zinc finger and BTB domain-containing protein 7B (Zbtb7b) which is also known as, T-helper-inducing POZ/Krueppel-like factor (Th-POK), Krueppel-related zinc finger protein cKrox (cKrox), or Zinc finger protein 67 (Zfp67)
• Zbtb7b is a Zn2+ finger-containing transcription factor that acts as a transcriptional repressor or activator in a promoter-dependent manner
• Zbtb7b plays a role in thymic selection of T cells and is expressed in CD4+CD8+ thymocytes and mature CD4+CD8- thymocytes and T cells
• It is not expressed by mature CD4-CD8+ thymocytes and T cells
• It indirectly increases the expression of CD4 in developing T cells by antagonizing Runx-3-mediated CD4 repression
• Zbtb7b expression has also been found in NKT and gamma/delta T cells
• Zbtb7b plays a role in transcriptional repression of collagen gene expression as well.