7225550
BD Horizon™ CD3 Mouse, anti-Human, RY586, Clone: UCHT1, BD Horizon™
Mouse Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
CD3
Applications
Flow Cytometry
Host Species
Mouse
Target Species
Human
Clone
UCHT1
Conjugate
RY586
Regulatory Status
RUO
Primary or Secondary
Primary
Related Products
Description
- The UCHT1 monoclonal antibody specifically binds to the human CD3ε-chain, a 20-kDa subunit of the CD3/T cell antigen receptor complex
- CD3ε is expressed on 70-80% of normal human peripheral blood lymphocytes and 60-85% of thymocytes
- Studies from the HLDA Workshop show that this antibody is mitogenic for CD3ε-positive cells when used in conjunction with costimulatory agents such as pokeweed mitogen or anti-CD28 antibody
- CD3 plays a central role in signal transduction during antigen recognition. The UCHT1 antibody stains both surface and intracellular CD3ε unlike the other CD3 clone, HIT3a, that stains only extracellular CD3ε.
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Antigen: CD3
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Target Species: Human
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Conjugate: RY586
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Antigen: CD123
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