ST2 Recombinant Rabbit Monoclonal Antibody (003), Invitrogen™

Description

• Specificity: Human IL1RL1/IL1R4 IL-33R, also known as ST2, is a receptor for IL-33
• It is a member of the IL-1 receptor family of innate receptors
• Its extracellular domain consists of 3 Ig-like domains that directly interact with its co-receptor IL-1RAcP, and the ligand alarmin, IL-33
• IL-33 ligation results in the association of IL-33R complex with its adaptor proteins MyD88, IRAK1, IRAK4 and TRAF6, and activation of the NF-kB, and MAPK pathways
• This, in turn, instigates the release of chemokines and cytokines such as IL-5, IL-6, IL-8, and IL-13
• Two most common isoforms of IL-33R that result from alternative splicing are ST2L – the membrane bound form, and ST2S – the soluble form
• The membrane bound form can be released from the cell surface by proteolytic cleavage
• The soluble forms have been suggested to act as decoys dampening the IL-33 signaling
• IL-33R is primarily expressed by mast cells, basophils, and eosinophils
• In mouse, IL-33R expression has been shown on ILC2 and Th2 cells
• IL-33R signaling has been implicated in the number of immune conditions, including allergies, arthritis, atherosclerosis and sepsis.