7245217

4-1BB Ligand Polyclonal Antibody, PeproTech®, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer: Fischer Scientific

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Antigen

4-1BB Ligand

Applications

ELISA, Western Blot

Conjugate

Unconjugated

Host Species

Rabbit

Target Species

Human

Gene Accession No.

P41273

Gene ID (Entrez)

8744

Immunogen

E.coli-derived Recombinant Human 4-1BB Ligand

Purification Method

Antigen affinity chromatography

Gene

TNFSF9

Concentration

0.1-1.0 mg/mL

Classification

Polyclonal

Form

Lyophilized

Regulatory Status

RUO

Formulation

PBS with no preservative

Gene Alias

4 1 BB Ligand; 4 1 BBL; 41BB Ligand; 4-1BB ligand; 41BBL; 4-1BBL; 4-1BB-L; AI848817; CD 137 Ligand; CD 137L; CD137 Ligand; CD137L; Cd157l; CDw137L; costimulatory molecule; homolog of mouse 4-1BB-L; Ly63l; receptor 4-1BB ligand; TNFRSF9; Tnfsf9; TNLG5A; tumor necrosis factor (ligand) superfamily member 9; tumor necrosis factor (ligand) superfamily, member 9; tumor necrosis factor ligand 5A; tumor necrosis factor ligand superfamily member 9; tumor necrosis factor superfamily member 9

Gene Symbols

TNFSF9

Primary or Secondary

Primary

Content And Storage

-20°C

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Description

  • AA Sequence of recombinant protein: MREGPELSPD DPAGLLDLRQ GMFAQLVAQN VLLIDGPLSW YSDPGLAGVS LTGGLSYKED TKELVVAKAG VYYVFFQLEL RRVVAGEGSG SVSLALHLQP LRSAAGAAAL ALTVDLPPAS SEARNSAFGF QGRLLHLSAG QRLGVHLHTE ARARHAWQLT QGATVLGLFR VTPEIPAGLP SPRSE
  • Preparation: Produced from sera of rabbits immunized with highly pure Recombinant Human 4-1BB Ligand
  • Anti-Human 4-1BB Ligand-specific antibody was purified by affinity chromatography employing an immobilized Human 4-1BB Ligand matrix
  • Sandwich ELISA: To detect Human 4-1BB Ligand by sandwich ELISA (using 100 μL/well antibody solution) a concentration of 0.5-2.0 μg/mL of this antibody is required
  • This antigen affinity purified antibody, in conjunction with PeproTech Biotinylated Anti-Human 4-1BB Ligand (500-P169Bt) as a detection antibody, allows the detection of at least 0.2-0.4 ng/well of Recombinant Human 4-1BB Ligand
  • Western Blot: To detect Human 4-1BB Ligand by Western Blot analysis this antibody can be used at a concentration of 0.1-0.2 μg/mL
  • When used in conjunction with compatible secondary reagents, the detection limit for Recombinant Human 4-1BB Ligand is 1.5-3.0 ng/lane, under either reducing or non-reducing conditions
  • CD137 ligand (CD137L) is a type II membrane protein and part of the TNF superfamily
  • CD137L is a co-stimulatory molecule that is expressed on antigen presenting cells (DCs, monocytes/macrophages, B cells) and is upregulated upon activation
  • Its receptor, CD137/4-1BB, is found on a variety of cells, including inflamed endothelial cells, where its expression enhances extravasation of CD137L expressing monocytes
  • Activated T cells also express CD137, and engagement with CD137L enhances T cell proliferation, IL-2 secretion, survival, and cytotoxic activity
  • CD137L is also expressed on a majority of B-cell lymphomas, including mantle cell lymphoma, follicular lymphoma, and diffuse large B-cell lymphoma (but it is lacking on Hodgkin lymphoma and T-cell lymphoma)
  • CD137L is also expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interactions.

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7245217

Rabbit Polyclonal Antibody...


Antigen:
4-1BB Ligand

Applications:
ELISA, Western Blot

Conjugate:
Unconjugated

Host Species:
Rabbit

Target Species:
Human

Gene Accession No.:
P41273

Gene ID (Entrez):
8744

Immunogen:
E.coli-derived Recombinant Human 4-1BB Ligand

Purification Method:
Antigen affinity chromatography

Gene:
TNFSF9

Concentration:
0.1-1.0 mg/mL

Classification:
Polyclonal

Form:
Lyophilized

Regulatory Status:
RUO

Formulation:
PBS with no preservative

Gene Alias:
4 1 BB Ligand; 4 1 BBL; 41BB Ligand; 4-1BB ligand; 41BBL; 4-1BBL; 4-1BB-L; AI848817; CD 137 Ligand; CD 137L; CD137 Ligand; CD137L; Cd157l; CDw137L; costimulatory molecule; homolog of mouse 4-1BB-L; Ly63l; receptor 4-1BB ligand; TNFRSF9; Tnfsf9; TNLG5A; tumor necrosis factor (ligand) superfamily member 9; tumor necrosis factor (ligand) superfamily, member 9; tumor necrosis factor ligand 5A; tumor necrosis factor ligand superfamily member 9; tumor necrosis factor superfamily member 9

Gene Symbols:
TNFSF9

Primary or Secondary:
Primary

Content And Storage:
-20°C

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7245218

Rabbit Polyclonal Antibody...


Antigen:
IL-6

Applications:
ELISA, Western Blot

Conjugate:
Biotin

Host Species:
Rabbit

Target Species:
Mouse

Gene Accession No.:
P08505

Gene ID (Entrez):
16193

Immunogen:
E.coli-derived Recombinant Murine IL-6

Purification Method:
Antigen affinity chromatography

Gene:
Il6

Concentration:
0.1-1.0 mg/mL

Classification:
Polyclonal

Form:
Lyophilized

Regulatory Status:
RUO

Formulation:
PBS with no preservative

Gene Alias:
B-cell differentiation factor; B-cell hybridoma growth factor; B-cell stimulatory factor 2; BSF2; BSF-2; CDF; CHIL-6; CTL differentiation factor; cytokine; HGF; H-IL-6; HSF; hybridoma growth factor; Ifnb2; IFN-beta-2; Il6; IL-6; ILg6; ILN; interferon beta-2; Interleukin; interleukin 6; Interleukin 6 (interferon, beta 2); interleukin 6 precursor; interleukin BSF-2; interleukin HP-1; Interleukin6; Interleukin-6; interleukin-6 precursor; interleukin-6 protein; M-IL-6; prointerleukin 6; R-IL-6

Gene Symbols:
Il6

Primary or Secondary:
Primary

Content And Storage:
-20°C

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Antigen:
IL-13

Applications:
ELISA, Western Blot

Conjugate:
Unconjugated

Host Species:
Rabbit

Target Species:
Human

Gene Accession No.:
P35225

Gene ID (Entrez):
3596

Immunogen:
E.coli-derived Recombinant Human IL-13

Purification Method:
Antigen affinity chromatography

Gene:
Il13

Concentration:
0.1-1.0 mg/mL

Classification:
Polyclonal

Form:
Lyophilized

Regulatory Status:
RUO

Formulation:
PBS with no preservative

Gene Alias:
ALRH; ALRH antibody; BHR1; il 13; Il13; Il-13; IL-13; cytokine; ILN; Interleukin; interleukin 13; Interleukin13; interleukin-13; interleukin-13 precursor; L13; MGC116786; MGC116788; MGC116789; NC30; NC30 antibody; P600; P600 antibody; T-cell activation protein P600

Gene Symbols:
Il13

Primary or Secondary:
Primary

Content And Storage:
-20°C

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Antigen:
IL-3 beta

Applications:
ELISA, Western Blot

Conjugate:
Biotin

Host Species:
Goat

Target Species:
Rat

Gene Accession No.:
P04823

Gene ID (Entrez):
24495

Immunogen:
E.coli-derived Recombinant Rat IL-3beta

Purification Method:
Antigen affinity chromatography

Gene:
Il3

Concentration:
0.1-1.0 mg/mL

Classification:
Polyclonal

Form:
Lyophilized

Regulatory Status:
RUO

Formulation:
PBS with no preservative

Gene Alias:
__

Gene Symbols:
Il3

Primary or Secondary:
Primary

Content And Storage:
-20°C