Synapsin 1 Polyclonal Antibody, Invitrogen™

Description

• This antibody has little or no activity against Synapsin II
• Storage and reconstitution: when stored at -20oC or below, the lyophilized antibody should retain full activity for over one year
• Reconstitute using 50 μL PBS, pH 7.4, to yield a 0.2 mg/mL solution
• If storing at 0-4oC, add sodium azide to a final concentration of 2mM
• For longer storage, divide the solution into aliquots and freeze at -20oC, avoiding freeze/thaw cycles
• SYN1 (synapsin 1) is a member of the synapsin gene family
• Synapsins encode neuronal phosphoproteins that associate with the cytoplasmic surface of synaptic vesicles
• Family members are characterized by common protein domains and are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases
• Synapsin 1 plays a role in regulation of axonogenesis and synaptogenesis
• It serves as a substrate for several different protein kinases and phosphorylation may function in the regulation of this protein in the nerve terminal
• Mutations in this gene may be associated with X-linked disorders with primary neuronal degeneration such as Rett syndrome
• Alternatively spliced transcript variants encoding different isoforms have been identified.