ABE1307MI

MilliporeSigma™ Rabbit anti-CHD1L, Polyclonal,

Manufacturer: MilliporeSigma™

Select a Size

Pack Size SKU Availability Price
Each of 1 ABE1307MI-Each-of-1 In Stock ₹ 40,197.80

ABE1307MI - Each of 1

₹ 40,197.80

In Stock

Quantity

1

Base Price: ₹ 40,197.80

GST (18%): ₹ 7,235.604

Total Price: ₹ 47,433.404

Antigen

CHD1L

Classification

Polyclonal

Gene Accession No.

Q86WJ1

Host Species

Rabbit

Purification Method

Affinity Purified

Regulatory Status

RUO

Primary or Secondary

Primary

Target Species

Human

Applications

Western Blot

Formulation

Purified rabbit polyclonal in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.

Gene Symbols

CHD1L; ALC1

Immunogen

KLH-conjugated linear peptide corresponding to the Helicase C-terminal domain of human CHD1L.

Quantity

100 μg

Research Discipline

Epigenetics and Nuclear Function

Gene ID (Entrez)

NP_004275

Content And Storage

Stable for one year at 2°C to 8°C from date of receipt.

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Description

  • Specifically detects CHD1L in Human samples, and it is validated for Western Blotting Chromodomain helicase/ATPase DNA binding protein 1-like gene (CHD1L) is a ∼100.9kDa DNA helicase that is amplified in many solid tumors
  • The CHD1L gene, located at Chr 1q21 is frequently amplified in hepatocellular carcinoma
  • CHD1L plays a role in chromatin remodeling following DNA damage
  • It is targeted to DNA damage sites through interaction with poly(ADP)-ribose) and regulated chromatin during DNA repair
  • CHD1L contains a SNF2-N domain and a helicase superfamily domain, but unlike CHD1, it does not contain a chromodomain, but instead contains a c-terminal macrodomain, which is an (ADP)-ribose/ polymer of the ADP-ribose (PAR)-binding element
  • In addition to PAR binding, the macro domain of CHD1L is able to bind Nur77, a critical member of a p53-independent apoptotic pathway
  • This binding subsequently inhibits the nucleus-to-mitochondria translocation of Nur77 and disrupts apoptotic cell death
  • Overexpression of CHD1L protein in tumors is considered to be an independent biomarker of poor prognosis and short tumor-free survival time.

Compare Similar Items

Show Difference

Img

MilliporeSigma™

ABE1307MI

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Antigen:
CHD1L

Classification:
Polyclonal

Gene Accession No.:
Q86WJ1

Host Species:
Rabbit

Purification Method:
Affinity Purified

Regulatory Status:
RUO

Primary or Secondary:
Primary

Target Species:
Human

Applications:
Western Blot

Formulation:
Purified rabbit polyclonal in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.

Gene Symbols:
CHD1L; ALC1

Immunogen:
KLH-conjugated linear peptide corresponding to the Helicase C-terminal domain of human CHD1L.

Quantity:
100 μg

Research Discipline:
Epigenetics and Nuclear Function

Gene ID (Entrez):
NP_004275

Content And Storage:
Stable for one year at 2°C to 8°C from date of receipt.

Img

MilliporeSigma™

ABE1310MI

--


Antigen:
ALKBH1

Classification:
Polyclonal

Gene Accession No.:
Q13686

Host Species:
Rabbit

Purification Method:
Affinity Purified

Regulatory Status:
RUO

Primary or Secondary:
Primary

Target Species:
Human, Mouse

Applications:
Immunocytochemistry, Immunohistochemistry

Formulation:
Purified rabbit polyclonal in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.

Gene Symbols:
ALKBH1; ABH; ABH1; ALKBH

Immunogen:
KLH-conjugated linear peptide corresponding to the substrate binding region of human ALKBH1.

Quantity:
100 μg

Research Discipline:
Epigenetics and Nuclear Function

Gene ID (Entrez):
NP_006011

Content And Storage:
Stable for one year at 2°C to 8°C from date of receipt.

Img

MilliporeSigma™

ABE1313MI

--


Antigen:
SMARCD3

Classification:
Polyclonal

Gene Accession No.:
Q6STE5

Host Species:
Rabbit

Purification Method:
Affinity Purified

Regulatory Status:
RUO

Primary or Secondary:
Primary

Target Species:
Human, Mouse

Applications:
Immunocytochemistry, Western Blot

Formulation:
Purified rabbit polyclonal in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.

Gene Symbols:
SMARCD3; BAF60C

Immunogen:
KLH-conjugated linear peptide corresponding to the SWIB domain of human SMARCD3.

Quantity:
100 μg

Research Discipline:
Epigenetics and Nuclear Function

Gene ID (Entrez):
NP_003069

Content And Storage:
Stable for one year at 2°C to 8°C from date of receipt.

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ABE1317MI

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Antigen:
phospho Cyclin-dependent kinase 7 (Thr170)

Classification:
Polyclonal

Gene Accession No.:
__

Host Species:
Rabbit

Purification Method:
Affinity Purified

Regulatory Status:
__

Primary or Secondary:
Primary

Target Species:
Human, Mouse, Rat

Applications:
ChIP Assay, Western Blot

Formulation:
Purified rabbit polyclonal in buffer containing PBS with 0.05% sodium azide.

Gene Symbols:
CDK7; CAK; CAK1; CDKN7; MO15; STK1

Immunogen:
Linear peptide corresponding to human phosphorylated phospho Cyclin-dependent kinase 7 (Thr170).

Quantity:
100 μg

Research Discipline:
__

Gene ID (Entrez):
NP_001790

Content And Storage:
2-8°C for 12 months