ABE141825UG
Histone acetyltransferase KAT2A, Rabbit anti-Human, Polyclonal, Millipore Sigma™
Manufacturer: MilliporeSigma
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | ABE141825UG-Each-of-1 | In Stock | ₹ 16,456.61 |
ABE141825UG - Each of 1
In Stock
Quantity
1
Base Price: ₹ 16,456.61
GST (18%): ₹ 2,962.19
Total Price: ₹ 19,418.80
Antigen
Histone acetyltransferase KAT2A
Classification
Polyclonal
Dilution
Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected Histone acetyltransferase KAT2A in human pancreas, cerebral cortex, and tonsil tissue sections.
Gene Alias
General control of amino acid synthesis protein 5-like 2;Histone acetyltransferase GCN5;HsGCN5;Lysine acetyltransferase 2A;STAF97
Host Species
Rabbit
Molecular Weight of Antigen
∽94 kDa observed; 93.93 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
Quantity
25 μg
Research Discipline
Epigenetics & Nuclear Function
Test Specificity
This rabbit polyclonal antibody detects Histone acetyltransferase KAT2A in human cells. It targets an epitope within 15 amino acids from the C-terminal half.
Content And Storage
Stable for 1 year at 2-8°C from date of receipt.
Applications
Immunohistochemistry (Paraffin), Western Blot
Conjugate
Unconjugated
Formulation
Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols
KAT2A;GCN5;GCN5L2;HGCN5
Immunogen
KLH-conjugated linear peptide corresponding to 15 amino acids from the C-terminal half of human Histone acetyltransferase KAT2A.
Purification Method
Affinity Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Target Species
Human
Description
- Anti-Histone acetyltransferase KAT2A, Cat
- No
- ABE1418, is a highly specific rabbit polyclonal antibody that detects KAT2A (GCN5) and has been tested for use in Immunohistochemistry (Paraffin) and Western Blotting
- Histone acetyltransferase KAT2A (UniProt: Q92830; also known as EC 2.3.1.48, General control of amino acid synthesis protein 5-like 2, Histone acetyltransferase GCN5, HsGCN5, Lysine acetyltransferase 2A, STAF97) is encoded by the KAT2A (also known as GCN5, GCN5L2, HGCN5) gene (Gene ID: 2648) in human
- Histone acetyltransferases (HATs) are transcription co-activators recruited by transcriptional activators to target gene promoters, where they enhance the transcription activity by acetylating lysine residues within the N-terminal regions of histones
- KAT2A has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles
- It is also shown to acetylate non-histone proteins, such as CEBPB
- It is also responsible for the acetylation of histone H3 at the gamma-H2A.X harboring nucleosomes at the site of DNA damage, thus establishing a cross-talk between the two histone modifications
- It is expressed in all tissues and high expression is observed in ovary
- Two isoforms of KAT2A have been described that are produced by alternative splicing
- It has three acetyl CoA-binding sites (aa 579-581; 586-592, and 617-620) and an N-acetyltransferase domain (aa 503-656) and a bromo domain (aa 745-815)
- Histone acetyltransferase KAT2A plays important roles in multiple stages of T cell functions, including development, clonal expansion, and differentiation
- Loss of its activity is shown to impair T cell proliferation, IL-2 production, and Th1/Th17, but not Th2 and regulatory T cell differentiation
- In case of HIV-1 infection, it is recruited by the viral protein Tat and regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes
- (Ref.: (Ref.: Gao, B et al
- (2017)
- J
- Immunol
- 198(10); 3927-3938).
Compare Similar Items
Show Difference
Antigen: Histone acetyltransferase KAT2A
Classification: Polyclonal
Dilution: Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected Histone acetyltransferase KAT2A in human pancreas, cerebral cortex, and tonsil tissue sections.
Gene Alias: General control of amino acid synthesis protein 5-like 2;Histone acetyltransferase GCN5;HsGCN5;Lysine acetyltransferase 2A;STAF97
Host Species: Rabbit
Molecular Weight of Antigen: ∽94 kDa observed; 93.93 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
Quantity: 25 μg
Research Discipline: Epigenetics & Nuclear Function
Test Specificity: This rabbit polyclonal antibody detects Histone acetyltransferase KAT2A in human cells. It targets an epitope within 15 amino acids from the C-terminal half.
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Applications: Immunohistochemistry (Paraffin), Western Blot
Conjugate: Unconjugated
Formulation: Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols: KAT2A;GCN5;GCN5L2;HGCN5
Immunogen: KLH-conjugated linear peptide corresponding to 15 amino acids from the C-terminal half of human Histone acetyltransferase KAT2A.
Purification Method: Affinity Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Target Species: Human
Antigen:
Histone acetyltransferase KAT2A
Classification:
Polyclonal
Dilution:
Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected Histone acetyltransferase KAT2A in human pancreas, cerebral cortex, and tonsil tissue sections.
Gene Alias:
General control of amino acid synthesis protein 5-like 2;Histone acetyltransferase GCN5;HsGCN5;Lysine acetyltransferase 2A;STAF97
Host Species:
Rabbit
Molecular Weight of Antigen:
∽94 kDa observed; 93.93 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
Quantity:
25 μg
Research Discipline:
Epigenetics & Nuclear Function
Test Specificity:
This rabbit polyclonal antibody detects Histone acetyltransferase KAT2A in human cells. It targets an epitope within 15 amino acids from the C-terminal half.
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.
Applications:
Immunohistochemistry (Paraffin), Western Blot
Conjugate:
Unconjugated
Formulation:
Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols:
KAT2A;GCN5;GCN5L2;HGCN5
Immunogen:
KLH-conjugated linear peptide corresponding to 15 amino acids from the C-terminal half of human Histone acetyltransferase KAT2A.
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Target Species:
Human
Antigen: __
Classification: __
Dilution: __
Gene Alias: __
Host Species: __
Molecular Weight of Antigen: __
Quantity: __
Research Discipline: __
Test Specificity: __
Content And Storage: __
Applications: __
Conjugate: __
Formulation: __
Gene Symbols: __
Immunogen: __
Purification Method: __
Regulatory Status: __
Primary or Secondary: __
Target Species: __
Antigen:
__
Classification:
__
Dilution:
__
Gene Alias:
__
Host Species:
__
Molecular Weight of Antigen:
__
Quantity:
__
Research Discipline:
__
Test Specificity:
__
Content And Storage:
__
Applications:
__
Conjugate:
__
Formulation:
__
Gene Symbols:
__
Immunogen:
__
Purification Method:
__
Regulatory Status:
__
Primary or Secondary:
__
Target Species:
__
Antigen: Mediator complex subunit 25
Classification: Polyclonal
Dilution: __
Gene Alias: __
Host Species: Rabbit
Molecular Weight of Antigen: __
Quantity: 25 μg
Research Discipline: Epigenetics and Nuclear Function
Test Specificity: This rabbit polyclonal antibody detects Mediator of RNA polymerase II transcription subunit 25 (MED25) in human and murine species. it targets an epitope within 16 amino acids from the internal region. Detects all isoforms of Mediator complex subunit 25.
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Applications: Western Blot, Inhibition Assays, Immunohistochemistry (Paraffin)
Conjugate: Unconjugated
Formulation: __
Gene Symbols: MED25,ACID1,ARC92,PTOV2,TCBAP0758
Immunogen: KLH-conjugated linear peptide corresponding to 16 amino acids from the internal region of human Mediator of RNA polymerase II transcription subunit 25 (MED25).
Purification Method: Affinity Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Target Species: Mouse, Human
Antigen:
Mediator complex subunit 25
Classification:
Polyclonal
Dilution:
__
Gene Alias:
__
Host Species:
Rabbit
Molecular Weight of Antigen:
__
Quantity:
25 μg
Research Discipline:
Epigenetics and Nuclear Function
Test Specificity:
This rabbit polyclonal antibody detects Mediator of RNA polymerase II transcription subunit 25 (MED25) in human and murine species. it targets an epitope within 16 amino acids from the internal region. Detects all isoforms of Mediator complex subunit 25.
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.
Applications:
Western Blot, Inhibition Assays, Immunohistochemistry (Paraffin)
Conjugate:
Unconjugated
Formulation:
__
Gene Symbols:
MED25,ACID1,ARC92,PTOV2,TCBAP0758
Immunogen:
KLH-conjugated linear peptide corresponding to 16 amino acids from the internal region of human Mediator of RNA polymerase II transcription subunit 25 (MED25).
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Target Species:
Mouse, Human
Antigen: Glucocorticoid Receptor
Classification: Polyclonal
Dilution: __
Gene Alias: __
Host Species: Rabbit
Molecular Weight of Antigen: __
Quantity: 100 μL
Research Discipline: Epigenetics, Nuclear Function
Test Specificity: Expected to react with all 10 spliced isoforms reported by UniProt (P04150-1 through P04150-10).
Content And Storage: −20°C for one year
Applications: Western Blot
Conjugate: Unconjugated
Formulation: Rabbit polyclonal antibody in serum with 0.05% sodium azide.
Gene Symbols: NR3C1, GCCR, GCR, GCRST, GRL
Immunogen: KLH-conjugated linear peptide corresponding to a sequence from the modulating region of human glucocorticoid receptor.
Purification Method: Unpurified
Regulatory Status: RUO
Primary or Secondary: Primary
Target Species: Human, Mouse
Antigen:
Glucocorticoid Receptor
Classification:
Polyclonal
Dilution:
__
Gene Alias:
__
Host Species:
Rabbit
Molecular Weight of Antigen:
__
Quantity:
100 μL
Research Discipline:
Epigenetics, Nuclear Function
Test Specificity:
Expected to react with all 10 spliced isoforms reported by UniProt (P04150-1 through P04150-10).
Content And Storage:
−20°C for one year
Applications:
Western Blot
Conjugate:
Unconjugated
Formulation:
Rabbit polyclonal antibody in serum with 0.05% sodium azide.
Gene Symbols:
NR3C1, GCCR, GCR, GCRST, GRL
Immunogen:
KLH-conjugated linear peptide corresponding to a sequence from the modulating region of human glucocorticoid receptor.
Purification Method:
Unpurified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Target Species:
Human, Mouse