ABF116925UL
Pyrin, Rabbit anti-Human, Polyclonal, Millipore Sigma™
Manufacturer: MilliporeSigma
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | ABF116925UL-Each-of-1 | In Stock | ₹ 16,456.61 |
ABF116925UL - Each of 1
In Stock
Quantity
1
Base Price: ₹ 16,456.61
GST (18%): ₹ 2,962.19
Total Price: ₹ 19,418.80
Antigen
Pyrin
Classification
Polyclonal
Dilution
Immunohistochemistry Analysis: A 1:250 dilution from a representative lot detected Pyrin in human tonsil, human cerebral cortex, human skeletal muscle, and human pancreatic cancer tissues.
Gene Alias
Marenostrin
Host Species
Rabbit
Molecular Weight of Antigen
∽82 kDa observed; 86.44 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
Quantity
25 μL
Research Discipline
Inflammation & Immunology
Test Specificity
This rabbit polyclonal antibody detects Pyrin in human cells. It targets an epitope within 15 amino acids from the N-terminal region.
Content And Storage
Stable for 1 year at 2-8°C from date of receipt.
Applications
Immunohistochemistry (Paraffin), Western Blot
Conjugate
Unconjugated
Formulation
Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols
MEFV;MEF;TRIM20
Immunogen
KLH-conjugated linear peptide corresponding to 15 amino acids from the N-terminal region of human Pyrin, isoform 1.
Purification Method
Affinity Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Target Species
Human
Description
- Anti-Pyrin, Cat
- No
- ABF1169, is a rabbit polyclonal antibody that detects human Pyrin and has been tested for use in Immunohistochemistry (Paraffin) and Western Blotting
- Pyrin (UniProt: O15553; also known as Marenostrin) is encoded by the MEFV (also known as MEF, TRIM20) gene (Gene ID: 4210) in human
- Pyrin is a homotrimeric protein that is involved in the regulation of innate immunity and the inflammatory response in response to IFNG/IFN-gamma
- It organizes autophagic machinery by serving as a platform for the assembly of ULK1, Beclin 1/BECN1, ATG16L1, and ATG8 family members and recognizes specific autophagy targets, thus coordinating target recognition with assembly of the autophagic apparatus and initiation of autophagy
- Pyrin acts as an autophagy receptor for the degradation of several inflammasome components, including CASP1, NLRP1 and NLRP3, hence it may prevent excessive IL-1B- and IL-18-mediated inflammation
- Pyrin is expressed in peripheral blood leukocytes, particularly in mature granulocytes and to a lesser extent in monocytes, but not in lymphocytes
- It is also detected in spleen, lung and muscle, probably as a result of leukocyte infiltration in these tissues
- Its expression is also detected in several myeloid leukemic, colon cancer, and prostate cancer cell lines
- Three isoforms of Pyrin have been described that are produced by alternative splicing
- Isoform 1 associates with microtubules and with the filamentous actin of perinuclear filaments and peripheral lamellar ruffles
- In pre-apoptotic cells, it co-localizes with PYCARD/ASC in large specks (inflammasome)
- Isoform 2 is shown to be localized to the nucleus.
Compare Similar Items
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Antigen: Pyrin
Classification: Polyclonal
Dilution: Immunohistochemistry Analysis: A 1:250 dilution from a representative lot detected Pyrin in human tonsil, human cerebral cortex, human skeletal muscle, and human pancreatic cancer tissues.
Gene Alias: Marenostrin
Host Species: Rabbit
Molecular Weight of Antigen: ∽82 kDa observed; 86.44 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
Quantity: 25 μL
Research Discipline: Inflammation & Immunology
Test Specificity: This rabbit polyclonal antibody detects Pyrin in human cells. It targets an epitope within 15 amino acids from the N-terminal region.
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Applications: Immunohistochemistry (Paraffin), Western Blot
Conjugate: Unconjugated
Formulation: Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols: MEFV;MEF;TRIM20
Immunogen: KLH-conjugated linear peptide corresponding to 15 amino acids from the N-terminal region of human Pyrin, isoform 1.
Purification Method: Affinity Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Target Species: Human
Antigen:
Pyrin
Classification:
Polyclonal
Dilution:
Immunohistochemistry Analysis: A 1:250 dilution from a representative lot detected Pyrin in human tonsil, human cerebral cortex, human skeletal muscle, and human pancreatic cancer tissues.
Gene Alias:
Marenostrin
Host Species:
Rabbit
Molecular Weight of Antigen:
∽82 kDa observed; 86.44 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
Quantity:
25 μL
Research Discipline:
Inflammation & Immunology
Test Specificity:
This rabbit polyclonal antibody detects Pyrin in human cells. It targets an epitope within 15 amino acids from the N-terminal region.
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.
Applications:
Immunohistochemistry (Paraffin), Western Blot
Conjugate:
Unconjugated
Formulation:
Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols:
MEFV;MEF;TRIM20
Immunogen:
KLH-conjugated linear peptide corresponding to 15 amino acids from the N-terminal region of human Pyrin, isoform 1.
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Target Species:
Human
Antigen: __
Classification: __
Dilution: __
Gene Alias: __
Host Species: __
Molecular Weight of Antigen: __
Quantity: __
Research Discipline: __
Test Specificity: __
Content And Storage: __
Applications: __
Conjugate: __
Formulation: __
Gene Symbols: __
Immunogen: __
Purification Method: __
Regulatory Status: __
Primary or Secondary: __
Target Species: __
Antigen:
__
Classification:
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Dilution:
__
Gene Alias:
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Host Species:
__
Molecular Weight of Antigen:
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Quantity:
__
Research Discipline:
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Test Specificity:
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Content And Storage:
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Conjugate:
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Formulation:
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Gene Symbols:
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Immunogen:
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Purification Method:
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Regulatory Status:
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Primary or Secondary:
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Target Species:
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Antigen: IFIT1/p56
Classification: Polyclonal
Dilution: __
Gene Alias: __
Host Species: Rabbit
Molecular Weight of Antigen: __
Quantity: 100 μL
Research Discipline: __
Test Specificity: __
Content And Storage: −20°C in undiluted aliquots for 12 months. Avoid repeated freeze/thaw cycles.
Applications: Flow Cytometry, Immunocytochemistry, Western Blot
Conjugate: Unconjugated
Formulation: Rabbit polyclonal serum containing 0.05% sodium azide.
Gene Symbols: Ifit1; Garg16; Ifi56; Isg56
Immunogen: GST-tagged recombinant protein corresponding to mouse IFIT1/p56.
Purification Method: Unpurified
Regulatory Status: __
Primary or Secondary: Primary
Target Species: Human, Mouse
Antigen:
IFIT1/p56
Classification:
Polyclonal
Dilution:
__
Gene Alias:
__
Host Species:
Rabbit
Molecular Weight of Antigen:
__
Quantity:
100 μL
Research Discipline:
__
Test Specificity:
__
Content And Storage:
−20°C in undiluted aliquots for 12 months. Avoid repeated freeze/thaw cycles.
Applications:
Flow Cytometry, Immunocytochemistry, Western Blot
Conjugate:
Unconjugated
Formulation:
Rabbit polyclonal serum containing 0.05% sodium azide.
Gene Symbols:
Ifit1; Garg16; Ifi56; Isg56
Immunogen:
GST-tagged recombinant protein corresponding to mouse IFIT1/p56.
Purification Method:
Unpurified
Regulatory Status:
__
Primary or Secondary:
Primary
Target Species:
Human, Mouse
Antigen: __
Classification: __
Dilution: __
Gene Alias: __
Host Species: __
Molecular Weight of Antigen: __
Quantity: __
Research Discipline: __
Test Specificity: __
Content And Storage: __
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Conjugate: __
Formulation: __
Gene Symbols: __
Immunogen: __
Purification Method: __
Regulatory Status: __
Primary or Secondary: __
Target Species: __
Antigen:
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Classification:
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Dilution:
__
Gene Alias:
__
Host Species:
__
Molecular Weight of Antigen:
__
Quantity:
__
Research Discipline:
__
Test Specificity:
__
Content And Storage:
__
Applications:
__
Conjugate:
__
Formulation:
__
Gene Symbols:
__
Immunogen:
__
Purification Method:
__
Regulatory Status:
__
Primary or Secondary:
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Target Species:
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