ABS149125UL
Frizzled-2, Rabbit anti-Human, Polyclonal, Millipore Sigma™
Manufacturer: Fischer Scientific
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | ABS149125UL-Each-of-1 | In Stock | ₹ 16,456.61 |
ABS149125UL - Each of 1
In Stock
Quantity
1
Base Price: ₹ 16,456.61
GST (18%): ₹ 2,962.19
Total Price: ₹ 19,418.80
Antigen
Frizzled-2
Classification
Polyclonal
Formulation
Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols
FZD2
Immunogen
KLH-conjugated linear peptide corresponding to 13 amino acids from the N-terminal half of human Frizzled-2.
Purification Method
Affinity Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Target Species
Human
Applications
Western Blot
Conjugate
Unconjugated
Gene Alias
Fz-2;hFz2;FzE2
Host Species
Rabbit
Molecular Weight of Antigen
∽60 kDa observed; 63.55 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
Quantity
25 μL
Research Discipline
Signaling
Test Specificity
This rabbit polyclonal antibody specifically detects human Frizzled -2. It targets an epitope with in 13 amino acids from the extracellular domain.
Content And Storage
Stable for 1 year at 2-8°C from date of receipt.
Related Products
Description
- Detects Frizzled-2 using this rabbit polyclonal Anti-Frizzled-2 Antibody, Cat
- No
- ABS1491, tested for use in Western Blotting
- Frizzled-2 (UniProt: Q14332; also known as Fz-2, hFz2, FzE2) is encoded by the FZD2 gene (Gene ID: 2535) in human
- Frizzled-2 is a multi-pass membrane protein that is widely expressed in adult tissues
- In fetus, higher levels are expressed in the brain, lung, and kidney and lower levels are observed in liver
- Frizzled serves as a receptor for Wnt proteins
- Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes
- In the presence of Wnt the Frizzled receptor is activated, which along with low-density lipoprotein receptor-related proteins (LRP) 5 and 6 stabilizes beta-catenin
- The formation of Wnt-Frizzled-LRP6 complex, together with the recruitment of the scaffolding protein Dishevelled (Dvl), results in LRP6 phosphorylation and activation and the recruitment of the Axin complex to the receptors
- This leads to the inhibition of Axin-mediated beta-catenin phosphorylation, which stabilizes beta-catenin
- Frizzled-2 is synthesized with a signal peptide (aa 1-23), which is subsequently cleaved off in the mature form
- Its Fz domain is localized to amino acids 34-153 and this domain is involved in its binding with Wnt ligands
- Frizzled-2 can be ubiquitinated by RING-type E3 ubiquitin transferase ZNRF3 leading to its proteasomal degradation
- Abnormalities in Wnt signaling are reported to promote birth defects, degenerative diseases, and cancer.
Compare Similar Items
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Antigen: Frizzled-2
Classification: Polyclonal
Formulation: Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols: FZD2
Immunogen: KLH-conjugated linear peptide corresponding to 13 amino acids from the N-terminal half of human Frizzled-2.
Purification Method: Affinity Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Target Species: Human
Applications: Western Blot
Conjugate: Unconjugated
Gene Alias: Fz-2;hFz2;FzE2
Host Species: Rabbit
Molecular Weight of Antigen: ∽60 kDa observed; 63.55 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
Quantity: 25 μL
Research Discipline: Signaling
Test Specificity: This rabbit polyclonal antibody specifically detects human Frizzled -2. It targets an epitope with in 13 amino acids from the extracellular domain.
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Antigen:
Frizzled-2
Classification:
Polyclonal
Formulation:
Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols:
FZD2
Immunogen:
KLH-conjugated linear peptide corresponding to 13 amino acids from the N-terminal half of human Frizzled-2.
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Target Species:
Human
Applications:
Western Blot
Conjugate:
Unconjugated
Gene Alias:
Fz-2;hFz2;FzE2
Host Species:
Rabbit
Molecular Weight of Antigen:
∽60 kDa observed; 63.55 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
Quantity:
25 μL
Research Discipline:
Signaling
Test Specificity:
This rabbit polyclonal antibody specifically detects human Frizzled -2. It targets an epitope with in 13 amino acids from the extracellular domain.
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.
Antigen: SCYL1
Classification: Polyclonal
Formulation: __
Gene Symbols: SCYL1,CVAK90,GKLP,NTKL,TAPK,TEIF,TRAP,HT01
Immunogen: KLH-conjugated linear peptide corresponding to 16 amino acids from the C-terminal region of human SCY1-Like Protein 1.
Purification Method: Affinity Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Target Species: Human, Mouse
Applications: Western Blot, Immunocytochemistry
Conjugate: Unconjugated
Gene Alias: __
Host Species: Rabbit
Molecular Weight of Antigen: __
Quantity: 100 μg
Research Discipline: Signaling
Test Specificity: This rabbit polyclonal antibody detects SCY1-Like Protein 1 (SCYL1) in human cells. It targets an epitope within 16 amino acids from the C-terminal region. The immunogen is conserved between isoforms 1, 2, and 3.
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Antigen:
SCYL1
Classification:
Polyclonal
Formulation:
__
Gene Symbols:
SCYL1,CVAK90,GKLP,NTKL,TAPK,TEIF,TRAP,HT01
Immunogen:
KLH-conjugated linear peptide corresponding to 16 amino acids from the C-terminal region of human SCY1-Like Protein 1.
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Target Species:
Human, Mouse
Applications:
Western Blot, Immunocytochemistry
Conjugate:
Unconjugated
Gene Alias:
__
Host Species:
Rabbit
Molecular Weight of Antigen:
__
Quantity:
100 μg
Research Discipline:
Signaling
Test Specificity:
This rabbit polyclonal antibody detects SCY1-Like Protein 1 (SCYL1) in human cells. It targets an epitope within 16 amino acids from the C-terminal region. The immunogen is conserved between isoforms 1, 2, and 3.
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.
Antigen: SCYL1
Classification: Polyclonal
Formulation: __
Gene Symbols: SCYL1,CVAK90,GKLP,NTKL,TAPK,TEIF,TRAP,HT01
Immunogen: KLH-conjugated linear peptide corresponding to 16 amino acids from the C-terminal region of human SCY1-Like Protein 1.
Purification Method: Affinity Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Target Species: Human, Mouse
Applications: Western Blot, Immunocytochemistry
Conjugate: Unconjugated
Gene Alias: __
Host Species: Rabbit
Molecular Weight of Antigen: __
Quantity: 25 μg
Research Discipline: Signaling
Test Specificity: This rabbit polyclonal antibody detects SCY1-Like Protein 1 (SCYL1) in human cells. It targets an epitope within 16 amino acids from the C-terminal region. The immunogen is conserved between isoforms 1, 2, and 3.
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Antigen:
SCYL1
Classification:
Polyclonal
Formulation:
__
Gene Symbols:
SCYL1,CVAK90,GKLP,NTKL,TAPK,TEIF,TRAP,HT01
Immunogen:
KLH-conjugated linear peptide corresponding to 16 amino acids from the C-terminal region of human SCY1-Like Protein 1.
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Target Species:
Human, Mouse
Applications:
Western Blot, Immunocytochemistry
Conjugate:
Unconjugated
Gene Alias:
__
Host Species:
Rabbit
Molecular Weight of Antigen:
__
Quantity:
25 μg
Research Discipline:
Signaling
Test Specificity:
This rabbit polyclonal antibody detects SCY1-Like Protein 1 (SCYL1) in human cells. It targets an epitope within 16 amino acids from the C-terminal region. The immunogen is conserved between isoforms 1, 2, and 3.
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.
Antigen: MYPT1
Classification: Polyclonal
Formulation: Purified rabbit polyclonal in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols: PPP1R12A; MBS; MYPT1
Immunogen: GST-tagged recombinant protein corresponding to chicken MYPT1.
Purification Method: Affinity Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Target Species: Human
Applications: Western Blot
Conjugate: __
Gene Alias: __
Host Species: Rabbit
Molecular Weight of Antigen: __
Quantity: 200 μL
Research Discipline: Signaling
Test Specificity: __
Content And Storage: Stable for one year at 2°C to 8°C from date of receipt.
Antigen:
MYPT1
Classification:
Polyclonal
Formulation:
Purified rabbit polyclonal in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols:
PPP1R12A; MBS; MYPT1
Immunogen:
GST-tagged recombinant protein corresponding to chicken MYPT1.
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Target Species:
Human
Applications:
Western Blot
Conjugate:
__
Gene Alias:
__
Host Species:
Rabbit
Molecular Weight of Antigen:
__
Quantity:
200 μL
Research Discipline:
Signaling
Test Specificity:
__
Content And Storage:
Stable for one year at 2°C to 8°C from date of receipt.