ABS1495MI
MilliporeSigma™ Rabbit anti-MYPT1, Polyclonal,
Manufacturer: MilliporeSigma™
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | ABS1495MI-Each-of-1 | In Stock | ₹ 38,734.72 |
ABS1495MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 38,734.72
GST (18%): ₹ 6,972.25
Total Price: ₹ 45,706.97
Antigen
MYPT1
Classification
Polyclonal
Gene Accession No.
Q90623
Host Species
Rabbit
Purification Method
Affinity Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Target Species
Human
Applications
Western Blot
Formulation
Purified rabbit polyclonal in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols
PPP1R12A; MBS; MYPT1
Immunogen
GST-tagged recombinant protein corresponding to chicken MYPT1.
Quantity
200 μL
Research Discipline
Signaling
Gene ID (Entrez)
NP_990454
Content And Storage
Stable for one year at 2°C to 8°C from date of receipt.
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Description
- Specifically detects MYPT1 in Human samples, and it is validated for Western Blotting Chicken Protein phosphatase 1 regulatory subunit 12A (also known as PP1M subunit M110, Myosin phosphatase target subunit 1, Myosin phosphatase-targeting subunit 1, Protein phosphatase myosin-binding subunit, Smooth muscle myosin phosphatase myosin-binding subunit, Protein phosphatase 1, regulatory (inhibitor) subunit 12A, 130kDa myosin-binding subunit of smooth muscle myosin phophatase) is encoded by the Gallus gallus PP1R12A (also known as MBS, MBSP, MYPT1) gene (Entrez Gene ID 396020)
- MYTP1 protein is one of the subunits and an integral component of Myosin phosphatase
- Myosin phosphatase regulates the interaction of Actin and Myosin downstream of the guanosine triphosphatase Rho, which inhibits Myosin phosphatase through the action of Rho-kinase
- It is also involved in smooth muscle contraction
- Inhibition of Myosin light chain phosphatase results in Ca 2+ sensitization of smooth muscle contraction
- This inhibition is modulated through phosphorylation of MYPT1 by a ZIP-like kinase, which associates with MYPTI and phosphorylates the inhibitory site in smooth muscle
- The phosphorylation of MYPT1 by protein kinase C results in altered dephosphoryation of Myosin by attenuating the binding of protein phosphatase 1 catalytic subunit (PP1c) and the phosphorylated 20kDa Myosin light chain to MYPT1
- PP1c interacts with at least four binding sites on the amino-terminus of MYPT1
- MYPT1 is localized on stress fibers, and is distributed close to the cell membrane and at cell-cell contacts to regulate Myosin phosphatase activity
- Anti-MYPT1 is raised against GST fustion protein containing recombinant chicken MYPT1 protein C-terminal tail fragment (UniProt Q90623) that is present in both isoform 1 (M133, 1004aa) and isoform 2 (M130, 963aa)
- Human reactivity of this product is confirmed by Western blotting analysis using HeLa cell lysate.
Compare Similar Items
Show Difference
Antigen: MYPT1
Classification: Polyclonal
Gene Accession No.: Q90623
Host Species: Rabbit
Purification Method: Affinity Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Target Species: Human
Applications: Western Blot
Formulation: Purified rabbit polyclonal in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols: PPP1R12A; MBS; MYPT1
Immunogen: GST-tagged recombinant protein corresponding to chicken MYPT1.
Quantity: 200 μL
Research Discipline: Signaling
Gene ID (Entrez): NP_990454
Content And Storage: Stable for one year at 2°C to 8°C from date of receipt.
Antigen:
MYPT1
Classification:
Polyclonal
Gene Accession No.:
Q90623
Host Species:
Rabbit
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Target Species:
Human
Applications:
Western Blot
Formulation:
Purified rabbit polyclonal in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols:
PPP1R12A; MBS; MYPT1
Immunogen:
GST-tagged recombinant protein corresponding to chicken MYPT1.
Quantity:
200 μL
Research Discipline:
Signaling
Gene ID (Entrez):
NP_990454
Content And Storage:
Stable for one year at 2°C to 8°C from date of receipt.
Antigen: __
Classification: __
Gene Accession No.: __
Host Species: __
Purification Method: __
Regulatory Status: __
Primary or Secondary: __
Target Species: __
Applications: __
Formulation: __
Gene Symbols: __
Immunogen: __
Quantity: __
Research Discipline: __
Gene ID (Entrez): __
Content And Storage: __
Antigen:
__
Classification:
__
Gene Accession No.:
__
Host Species:
__
Purification Method:
__
Regulatory Status:
__
Primary or Secondary:
__
Target Species:
__
Applications:
__
Formulation:
__
Gene Symbols:
__
Immunogen:
__
Quantity:
__
Research Discipline:
__
Gene ID (Entrez):
__
Content And Storage:
__
Antigen: Aurora B
Classification: Polyclonal
Gene Accession No.: __
Host Species: Rabbit
Purification Method: Affinity Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Target Species: Human
Applications: Western Blot, Immunocytochemistry
Formulation: __
Gene Symbols: AURKB,AIK2,AIM1,AIRK2,ARK2,STK1,STK12,STK5
Immunogen: KLH-conjugated Linear Peptide corresponding to the 11 amino acids from the C-terminal region of Human Aurora kinase B.
Quantity: 100 μg
Research Discipline: Signaling
Gene ID (Entrez): NP_001243763.1.
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Antigen:
Aurora B
Classification:
Polyclonal
Gene Accession No.:
__
Host Species:
Rabbit
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Target Species:
Human
Applications:
Western Blot, Immunocytochemistry
Formulation:
__
Gene Symbols:
AURKB,AIK2,AIM1,AIRK2,ARK2,STK1,STK12,STK5
Immunogen:
KLH-conjugated Linear Peptide corresponding to the 11 amino acids from the C-terminal region of Human Aurora kinase B.
Quantity:
100 μg
Research Discipline:
Signaling
Gene ID (Entrez):
NP_001243763.1.
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.
Antigen: SREBP-1
Classification: Polyclonal
Gene Accession No.: __
Host Species: Rabbit
Purification Method: Affinity Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Target Species: Human
Applications: Immunohistochemistry (Paraffin), Western Blot
Formulation: Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols: SREBF1;BHLHD1;SREBP1
Immunogen: KLH-conjugated linenar peptide corresponding to 14 amino acids from the N-terminal half of human Sterol regulatory element-binding protein 1. The Immunogen sequence is conserved in SREBP-1A, B, and C and in isoform 4.
Quantity: 25 μg
Research Discipline: Signaling
Gene ID (Entrez): __
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Antigen:
SREBP-1
Classification:
Polyclonal
Gene Accession No.:
__
Host Species:
Rabbit
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Target Species:
Human
Applications:
Immunohistochemistry (Paraffin), Western Blot
Formulation:
Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols:
SREBF1;BHLHD1;SREBP1
Immunogen:
KLH-conjugated linenar peptide corresponding to 14 amino acids from the N-terminal half of human Sterol regulatory element-binding protein 1. The Immunogen sequence is conserved in SREBP-1A, B, and C and in isoform 4.
Quantity:
25 μg
Research Discipline:
Signaling
Gene ID (Entrez):
__
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.