ABT137325UL
Aggrecan, Rabbit anti-Rat, Polyclonal, Millipore Sigma™
Manufacturer: MilliporeSigma
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | ABT137325UL-Each-of-1 | In Stock | ₹ 16,456.61 |
ABT137325UL - Each of 1
In Stock
Quantity
1
Base Price: ₹ 16,456.61
GST (18%): ₹ 2,962.19
Total Price: ₹ 19,418.80
Antigen
Aggrecan
Classification
Polyclonal
Dilution
Radioimmunoassay Analysis: A representative lot detected Aggrecan in Postnatal rat brain (Milev, P., et. al. (1998). Biochem Biopys Res Commun. 247(2):207-12).Immunohistochemistry Analysis: A representative lot detected Aggrecan in Embryonic day 16 rat eye, P0, P9 and adult rat retina (Popp, S., et. al. (2004). Exp Eye Res. 79(3):351-6) and Embryonic day 16, 19 rat brain and postnatal day 7 cerebellum, embryonic day 19 spinal cord (Popp, S., et. al. (2003). Dev Dyn. 227(1):143-9).Western Blotting Analysis: A representative lot detected Aggrecan in purified proteoglycans from a PBS extract of 7-day rat brain with chondroitinase ABC treatment (Popp, S., et. al. (2003). Dev Dyn. 227(1):143-9).
Gene Alias
Aggrecan core protein;Cartilage-specific proteoglycan core protein;CSPCP
Host Species
Rabbit
Molecular Weight of Antigen
221.12 kDa calculated
Quantity
25 μL
Research Discipline
Cell Structure
Test Specificity
This rabbit polyclonal antibody detects aggrecan in rat eye sections.
Content And Storage
Stable for 1 year at -20°C from date of receipt.
Isotype
IgG
Applications
Immunohistochemistry, Immunohistochemistry (Paraffin), Radioimmune Assays (RIA), Western Blot
Conjugate
Unconjugated
Formulation
Rabbit polyclonal antiserum with 0.05% sodium azide.
Gene Symbols
Acan;Agc;Agc1
Immunogen
GST-tagged recombinant fragment corresponding to 213 amino acids from the C-terminal half of rat Aggrecan.
Purification Method
Unpurified
Regulatory Status
RUO
Primary or Secondary
Primary
Target Species
Rat
Form
Serum
Related Products
Description
- Anti-Aggrecan, Cat
- No
- ABT1373, is a rabbit polyclonal antibody that detects Aggrecan core protein and is tested for use in Immunohistochemistry, Immunohistochemistry (Paraffin), Radioimmunoassay, and Western Blotting
- Aggrecan core protein (UniProt: P07897; also known as Cartilage-specific proteoglycan core protein, CSPCP) is encoded by the Acan (also known as Agc, Agc1) gene (GeneID: 58968) in rat
- Aggrecan is a secreted proteoglycan that is a major component of extracellular matrix of cartilagenous tissues
- Its major function is to resist compression in cartilage
- It binds avidly to hyaluronic acid via an N-terminal globular region and may play a regulatory role in the matrix assembly of the cartilage
- Aggrecan contains two globular domains, G1 and G2 that comprise the N-terminus of the proteoglycan, while another globular region, G3, makes up the C-terminus
- The G1 region is located in the N-terminus of the core protein and interacts with hyaluronic acid (HA)
- G1 contains Link domains and thus consists of three disulfide-bonded loop structures designated as the A, B, B' motifs
- The G2 region is composed of two B-like domains, but does not have the ability to interact with HA
- G2 region is separated from the G1 region by the interglobular domain, which is a prominent site for proteolysis
- The keratan sulfate (KS) and the chondroitin sulfate (CS) attachment domains lie between G2 and G3
- Aggrecan is present in the extracellular matrix in the form of proteoglycan aggregates, in which many aggrecan molecules interact with hyaluronan and a link protein stabilizes each interaction
- It is reported that aggrecan structure changes throughout the life cycle due to changes in synthetic and degradative events
- Changes due to synthesis alter the structure of the chondroitin sulfate and keratan sulfate chains, whereas those due to degradation cause cleavage of all components of the aggregate
- Aggrecan is also present in most of the retina including the outer nuclear layer, the outer plexiform layer, and the inner plexiform layer.
Compare Similar Items
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Antigen: Aggrecan
Classification: Polyclonal
Dilution: Radioimmunoassay Analysis: A representative lot detected Aggrecan in Postnatal rat brain (Milev, P., et. al. (1998). Biochem Biopys Res Commun. 247(2):207-12).Immunohistochemistry Analysis: A representative lot detected Aggrecan in Embryonic day 16 rat eye, P0, P9 and adult rat retina (Popp, S., et. al. (2004). Exp Eye Res. 79(3):351-6) and Embryonic day 16, 19 rat brain and postnatal day 7 cerebellum, embryonic day 19 spinal cord (Popp, S., et. al. (2003). Dev Dyn. 227(1):143-9).Western Blotting Analysis: A representative lot detected Aggrecan in purified proteoglycans from a PBS extract of 7-day rat brain with chondroitinase ABC treatment (Popp, S., et. al. (2003). Dev Dyn. 227(1):143-9).
Gene Alias: Aggrecan core protein;Cartilage-specific proteoglycan core protein;CSPCP
Host Species: Rabbit
Molecular Weight of Antigen: 221.12 kDa calculated
Quantity: 25 μL
Research Discipline: Cell Structure
Test Specificity: This rabbit polyclonal antibody detects aggrecan in rat eye sections.
Content And Storage: Stable for 1 year at -20°C from date of receipt.
Isotype: IgG
Applications: Immunohistochemistry, Immunohistochemistry (Paraffin), Radioimmune Assays (RIA), Western Blot
Conjugate: Unconjugated
Formulation: Rabbit polyclonal antiserum with 0.05% sodium azide.
Gene Symbols: Acan;Agc;Agc1
Immunogen: GST-tagged recombinant fragment corresponding to 213 amino acids from the C-terminal half of rat Aggrecan.
Purification Method: Unpurified
Regulatory Status: RUO
Primary or Secondary: Primary
Target Species: Rat
Form: Serum
Antigen:
Aggrecan
Classification:
Polyclonal
Dilution:
Radioimmunoassay Analysis: A representative lot detected Aggrecan in Postnatal rat brain (Milev, P., et. al. (1998). Biochem Biopys Res Commun. 247(2):207-12).Immunohistochemistry Analysis: A representative lot detected Aggrecan in Embryonic day 16 rat eye, P0, P9 and adult rat retina (Popp, S., et. al. (2004). Exp Eye Res. 79(3):351-6) and Embryonic day 16, 19 rat brain and postnatal day 7 cerebellum, embryonic day 19 spinal cord (Popp, S., et. al. (2003). Dev Dyn. 227(1):143-9).Western Blotting Analysis: A representative lot detected Aggrecan in purified proteoglycans from a PBS extract of 7-day rat brain with chondroitinase ABC treatment (Popp, S., et. al. (2003). Dev Dyn. 227(1):143-9).
Gene Alias:
Aggrecan core protein;Cartilage-specific proteoglycan core protein;CSPCP
Host Species:
Rabbit
Molecular Weight of Antigen:
221.12 kDa calculated
Quantity:
25 μL
Research Discipline:
Cell Structure
Test Specificity:
This rabbit polyclonal antibody detects aggrecan in rat eye sections.
Content And Storage:
Stable for 1 year at -20°C from date of receipt.
Isotype:
IgG
Applications:
Immunohistochemistry, Immunohistochemistry (Paraffin), Radioimmune Assays (RIA), Western Blot
Conjugate:
Unconjugated
Formulation:
Rabbit polyclonal antiserum with 0.05% sodium azide.
Gene Symbols:
Acan;Agc;Agc1
Immunogen:
GST-tagged recombinant fragment corresponding to 213 amino acids from the C-terminal half of rat Aggrecan.
Purification Method:
Unpurified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Target Species:
Rat
Form:
Serum
Antigen: Acetyl Cortactin (Lys309)
Classification: Polyclonal
Dilution: __
Gene Alias: __
Host Species: Rabbit
Molecular Weight of Antigen: __
Quantity: 100 μL
Research Discipline: Cell Structure
Test Specificity: This polyclonal antibody specifically detects Src substrate cortactin acetylated on Lysine 309.
Content And Storage: Stable for 1 year at -20°C from date of receipt.Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Isotype: __
Applications: Immunofluorescence, Western Blot
Conjugate: Unconjugated
Formulation: __
Gene Symbols: CTTN,EMS1
Immunogen: KLH-conjugated linear peptide corresponding to 14 amino acids surrounding acetylated lysine309 of human Src substrate cortactin.
Purification Method: Affinity Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Target Species: Monkey
Form: Purified
Antigen:
Acetyl Cortactin (Lys309)
Classification:
Polyclonal
Dilution:
__
Gene Alias:
__
Host Species:
Rabbit
Molecular Weight of Antigen:
__
Quantity:
100 μL
Research Discipline:
Cell Structure
Test Specificity:
This polyclonal antibody specifically detects Src substrate cortactin acetylated on Lysine 309.
Content And Storage:
Stable for 1 year at -20°C from date of receipt.Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Isotype:
__
Applications:
Immunofluorescence, Western Blot
Conjugate:
Unconjugated
Formulation:
__
Gene Symbols:
CTTN,EMS1
Immunogen:
KLH-conjugated linear peptide corresponding to 14 amino acids surrounding acetylated lysine309 of human Src substrate cortactin.
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Target Species:
Monkey
Form:
Purified
Antigen: __
Classification: __
Dilution: __
Gene Alias: __
Host Species: __
Molecular Weight of Antigen: __
Quantity: __
Research Discipline: __
Test Specificity: __
Content And Storage: __
Isotype: __
Applications: __
Conjugate: __
Formulation: __
Gene Symbols: __
Immunogen: __
Purification Method: __
Regulatory Status: __
Primary or Secondary: __
Target Species: __
Form: __
Antigen:
__
Classification:
__
Dilution:
__
Gene Alias:
__
Host Species:
__
Molecular Weight of Antigen:
__
Quantity:
__
Research Discipline:
__
Test Specificity:
__
Content And Storage:
__
Isotype:
__
Applications:
__
Conjugate:
__
Formulation:
__
Gene Symbols:
__
Immunogen:
__
Purification Method:
__
Regulatory Status:
__
Primary or Secondary:
__
Target Species:
__
Form:
__
Antigen: Neurocan
Classification: Polyclonal
Dilution: __
Gene Alias: Neurocan core protein;245 kDa early postnatal core glycoprotein;Chondroitin sulfate proteoglycan 3
Host Species: Rabbit
Molecular Weight of Antigen: 135.55 kDa calculated.
Quantity: 25 μL
Research Discipline: Cell Structure
Test Specificity: This rabbit polyclonal antibody detects Neurocan in fetal and adult rat brain.
Content And Storage: Stable for 1 year at -20°C from date of receipt.
Isotype: IgG
Applications: Immunofluorescence
Conjugate: Unconjugated
Formulation: Rabbit polyclonal antiserum with 0.05% sodium azide.
Gene Symbols: Ncan;Cspg3
Immunogen: Full-length Neurocan isolated from 7-day embryonic rat brain and purified by monoclonal antibody immunoaffinity chromatography.
Purification Method: Unpurified
Regulatory Status: RUO
Primary or Secondary: Primary
Target Species: Rat
Form: __
Antigen:
Neurocan
Classification:
Polyclonal
Dilution:
__
Gene Alias:
Neurocan core protein;245 kDa early postnatal core glycoprotein;Chondroitin sulfate proteoglycan 3
Host Species:
Rabbit
Molecular Weight of Antigen:
135.55 kDa calculated.
Quantity:
25 μL
Research Discipline:
Cell Structure
Test Specificity:
This rabbit polyclonal antibody detects Neurocan in fetal and adult rat brain.
Content And Storage:
Stable for 1 year at -20°C from date of receipt.
Isotype:
IgG
Applications:
Immunofluorescence
Conjugate:
Unconjugated
Formulation:
Rabbit polyclonal antiserum with 0.05% sodium azide.
Gene Symbols:
Ncan;Cspg3
Immunogen:
Full-length Neurocan isolated from 7-day embryonic rat brain and purified by monoclonal antibody immunoaffinity chromatography.
Purification Method:
Unpurified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Target Species:
Rat
Form:
__