ABT137025UL
Versican, Rabbit anti-Rat, Polyclonal, Millipore Sigma™
Manufacturer: MilliporeSigma
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | ABT137025UL-Each-of-1 | In Stock | ₹ 15,999.72 |
ABT137025UL - Each of 1
In Stock
Quantity
1
Base Price: ₹ 15,999.72
GST (18%): ₹ 2,879.95
Total Price: ₹ 18,879.67
Antigen
Versican
Classification
Polyclonal
Dilution
Radioimmunoassay Analysis: A representative lot detected Versican, Beta Domain in Postnatal rat brain (Milev, P., et. al. (1998). Biochem Biopys Res Commun. 247(2):207-12).Immunohistochemistry Analysis: A representative lot detected Versican, Beta Domain in Embryonic day 16 rat eye, P0, P9 and adult rat retina (Popp, S., et. al. (2004). Exp Eye Res. 79(3):351-6) and Embryonic day 16, 19 rat brain and postnatal day 7 cerebellum, embryonic day 19 spinal cord (Popp, S., et. al. (2003). Dev Dyn. 227(1):143-9).Western Blotting Analysis: A representative lot detected Versican, Beta Domain in purified proteoglycans from a PBS extract of 7-day rat brain with chondroitinase ABC treatment (Popp, S., et. al. (2003). Dev Dyn. 227(1):143-9).
Gene Alias
Chondroitin sulfate proteoglycan core protein 2;Glial hyaluronate-binding protein;GHAP;Large fibroblast proteoglycan;PG-M
Host Species
Rabbit
Molecular Weight of Antigen
300 kDa calculated.
Quantity
25 μL
Research Discipline
Apoptosis & Cancer
Test Specificity
This rabbit polyclonal antibody detects versican in rat eye sections.
Content And Storage
Stable for 1 year at -20°C from date of receipt.
Isotype
IgG
Applications
Immunohistochemistry (Paraffin), Radioimmune Assays (RIA), Western Blot
Conjugate
Unconjugated
Formulation
Rabbit polyclonal antiserum with 0.05% sodium azide.
Gene Symbols
Vcan;Cspg2
Immunogen
GST-tagged recombinant fragment corresponding to the 375 amino acids from the internal region of rat Versican.
Purification Method
Unpurified
Regulatory Status
RUO
Primary or Secondary
Primary
Target Species
Rat
Form
Serum
Related Products
Description
- Anti-Versican, Beta Domain, Cat
- No
- ABT1370 is a rabbit polyclonal antibody that detects versican core protein and has been tested for use in Immunohistochemistry (Paraffin), Radioimmunoassay, and Western Blotting
- Versican core protein (UniProt: Q9ERB4; also known as Chondroitin sulfate proteoglycan core protein 2, Glial hyaluronate-binding protein, GHAP, Large fibroblast proteoglycan, PG-M) is encoded by the Vcan (also known as Cspg2) gene (Gene ID: 114122) in rat
- Versican is a large multi-domain chondroitin sulphate proteoglycan that is secreted by fibroblasts and other types of cells
- Versican is present in most of the retina including the outer nuclear layer, the outer plexiform layer, and the inner plexiform layer
- It is synthesized with a 20 amino acid signal peptide, which is subsequently cleaved
- Veriscan plays a role in intercellular signaling and in connecting cells with the extracellular matrix and is also involved in axon regeneration, central nervous system and skeletal muscle development, and cell adhesion
- It has unique N- and C-terminal globular regions, each with multiple motifs
- It contains one C-type lectin domain, two EGF-like domains, one Ig-like V-type domain, two link domains and one Sushi (CCP/SCR) domains
- It also has a N-terminal hyaluronic acid (HA) binding domain that has homology with the G1 and G2 domains of aggrecan
- Four isoforms of versican termed as V0, V1, V2, and V3, have been reported with molecular weights of 370, 263, 180, and 74 kDa, respectively
- Each isoform contains different lengths of the GAG binding region
- V0 contains two GAG binding regions called CSalpha and CSbeta domains
- V1 isoform has only CSbeta and V2 isoform has only CSalpha domain
- V3 isoform contains only G1 and G3 domains and lacks GAG attachment sites
- Defects in Vcan gene result in Wagner syndrome type 1, a type of vitreoretinopathy characterized by an optically empty vitreous cavity with fibrillary condensations and a pre-retinal avascular membrane.
Compare Similar Items
Show Difference
Antigen: Versican
Classification: Polyclonal
Dilution: Radioimmunoassay Analysis: A representative lot detected Versican, Beta Domain in Postnatal rat brain (Milev, P., et. al. (1998). Biochem Biopys Res Commun. 247(2):207-12).Immunohistochemistry Analysis: A representative lot detected Versican, Beta Domain in Embryonic day 16 rat eye, P0, P9 and adult rat retina (Popp, S., et. al. (2004). Exp Eye Res. 79(3):351-6) and Embryonic day 16, 19 rat brain and postnatal day 7 cerebellum, embryonic day 19 spinal cord (Popp, S., et. al. (2003). Dev Dyn. 227(1):143-9).Western Blotting Analysis: A representative lot detected Versican, Beta Domain in purified proteoglycans from a PBS extract of 7-day rat brain with chondroitinase ABC treatment (Popp, S., et. al. (2003). Dev Dyn. 227(1):143-9).
Gene Alias: Chondroitin sulfate proteoglycan core protein 2;Glial hyaluronate-binding protein;GHAP;Large fibroblast proteoglycan;PG-M
Host Species: Rabbit
Molecular Weight of Antigen: 300 kDa calculated.
Quantity: 25 μL
Research Discipline: Apoptosis & Cancer
Test Specificity: This rabbit polyclonal antibody detects versican in rat eye sections.
Content And Storage: Stable for 1 year at -20°C from date of receipt.
Isotype: IgG
Applications: Immunohistochemistry (Paraffin), Radioimmune Assays (RIA), Western Blot
Conjugate: Unconjugated
Formulation: Rabbit polyclonal antiserum with 0.05% sodium azide.
Gene Symbols: Vcan;Cspg2
Immunogen: GST-tagged recombinant fragment corresponding to the 375 amino acids from the internal region of rat Versican.
Purification Method: Unpurified
Regulatory Status: RUO
Primary or Secondary: Primary
Target Species: Rat
Form: Serum
Antigen:
Versican
Classification:
Polyclonal
Dilution:
Radioimmunoassay Analysis: A representative lot detected Versican, Beta Domain in Postnatal rat brain (Milev, P., et. al. (1998). Biochem Biopys Res Commun. 247(2):207-12).Immunohistochemistry Analysis: A representative lot detected Versican, Beta Domain in Embryonic day 16 rat eye, P0, P9 and adult rat retina (Popp, S., et. al. (2004). Exp Eye Res. 79(3):351-6) and Embryonic day 16, 19 rat brain and postnatal day 7 cerebellum, embryonic day 19 spinal cord (Popp, S., et. al. (2003). Dev Dyn. 227(1):143-9).Western Blotting Analysis: A representative lot detected Versican, Beta Domain in purified proteoglycans from a PBS extract of 7-day rat brain with chondroitinase ABC treatment (Popp, S., et. al. (2003). Dev Dyn. 227(1):143-9).
Gene Alias:
Chondroitin sulfate proteoglycan core protein 2;Glial hyaluronate-binding protein;GHAP;Large fibroblast proteoglycan;PG-M
Host Species:
Rabbit
Molecular Weight of Antigen:
300 kDa calculated.
Quantity:
25 μL
Research Discipline:
Apoptosis & Cancer
Test Specificity:
This rabbit polyclonal antibody detects versican in rat eye sections.
Content And Storage:
Stable for 1 year at -20°C from date of receipt.
Isotype:
IgG
Applications:
Immunohistochemistry (Paraffin), Radioimmune Assays (RIA), Western Blot
Conjugate:
Unconjugated
Formulation:
Rabbit polyclonal antiserum with 0.05% sodium azide.
Gene Symbols:
Vcan;Cspg2
Immunogen:
GST-tagged recombinant fragment corresponding to the 375 amino acids from the internal region of rat Versican.
Purification Method:
Unpurified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Target Species:
Rat
Form:
Serum
Antigen: __
Classification: __
Dilution: __
Gene Alias: __
Host Species: __
Molecular Weight of Antigen: __
Quantity: __
Research Discipline: __
Test Specificity: __
Content And Storage: __
Isotype: __
Applications: __
Conjugate: __
Formulation: __
Gene Symbols: __
Immunogen: __
Purification Method: __
Regulatory Status: __
Primary or Secondary: __
Target Species: __
Form: __
Antigen:
__
Classification:
__
Dilution:
__
Gene Alias:
__
Host Species:
__
Molecular Weight of Antigen:
__
Quantity:
__
Research Discipline:
__
Test Specificity:
__
Content And Storage:
__
Isotype:
__
Applications:
__
Conjugate:
__
Formulation:
__
Gene Symbols:
__
Immunogen:
__
Purification Method:
__
Regulatory Status:
__
Primary or Secondary:
__
Target Species:
__
Form:
__
Antigen: phospho-Keratin-8 (Ser23)
Classification: Polyclonal
Dilution: __
Gene Alias: __
Host Species: Rabbit
Molecular Weight of Antigen: __
Quantity: 100 μL
Research Discipline: Cell Structure
Test Specificity: This rabbit polyclonal antibody detected the target phospho band only in lysates from phosphatase inhibitors-treated, but not untreated HeLa cells. Antibody blocking by the immunogen peptide, but not the corresponding nonphosphorylated peptide prior to immunoblotting abolished target band detection. The Ser23 designation is based on human keratin-8 sequence with initiator Met1 removed. The phosphorylation site sequence in mouse/rat (-SSR(pS)YT-) differs from that of human (-SSR(pS)FT-) by a single Phe24-to-Tyr24 switch (F24Y). Cross-reactivity of this polyclonal antibody toward murine and rat species is likely, but has not been confirmed.
Content And Storage: Stable for 1 year at 2°-8°C from date of receipt.
Isotype: __
Applications: Western Blot
Conjugate: Unconjugated
Formulation: Purified rabbit polyclonal antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Symbols: __
Immunogen: KLH-conjugated linear peptide corresponding to the phosphorylation site sequence containing the phosphorylated target serine.
Purification Method: Affinity Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Target Species: Human
Form: __
Antigen:
phospho-Keratin-8 (Ser23)
Classification:
Polyclonal
Dilution:
__
Gene Alias:
__
Host Species:
Rabbit
Molecular Weight of Antigen:
__
Quantity:
100 μL
Research Discipline:
Cell Structure
Test Specificity:
This rabbit polyclonal antibody detected the target phospho band only in lysates from phosphatase inhibitors-treated, but not untreated HeLa cells. Antibody blocking by the immunogen peptide, but not the corresponding nonphosphorylated peptide prior to immunoblotting abolished target band detection. The Ser23 designation is based on human keratin-8 sequence with initiator Met1 removed. The phosphorylation site sequence in mouse/rat (-SSR(pS)YT-) differs from that of human (-SSR(pS)FT-) by a single Phe24-to-Tyr24 switch (F24Y). Cross-reactivity of this polyclonal antibody toward murine and rat species is likely, but has not been confirmed.
Content And Storage:
Stable for 1 year at 2°-8°C from date of receipt.
Isotype:
__
Applications:
Western Blot
Conjugate:
Unconjugated
Formulation:
Purified rabbit polyclonal antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Symbols:
__
Immunogen:
KLH-conjugated linear peptide corresponding to the phosphorylation site sequence containing the phosphorylated target serine.
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Target Species:
Human
Form:
__
Antigen: Aggrecan
Classification: Polyclonal
Dilution: Radioimmunoassay Analysis: A representative lot detected Aggrecan in Postnatal rat brain (Milev, P., et. al. (1998). Biochem Biopys Res Commun. 247(2):207-12).Immunohistochemistry Analysis: A representative lot detected Aggrecan in Embryonic day 16 rat eye, P0, P9 and adult rat retina (Popp, S., et. al. (2004). Exp Eye Res. 79(3):351-6) and Embryonic day 16, 19 rat brain and postnatal day 7 cerebellum, embryonic day 19 spinal cord (Popp, S., et. al. (2003). Dev Dyn. 227(1):143-9).Western Blotting Analysis: A representative lot detected Aggrecan in purified proteoglycans from a PBS extract of 7-day rat brain with chondroitinase ABC treatment (Popp, S., et. al. (2003). Dev Dyn. 227(1):143-9).
Gene Alias: Aggrecan core protein;Cartilage-specific proteoglycan core protein;CSPCP
Host Species: Rabbit
Molecular Weight of Antigen: 221.12 kDa calculated
Quantity: 25 μL
Research Discipline: Cell Structure
Test Specificity: This rabbit polyclonal antibody detects aggrecan in rat eye sections.
Content And Storage: Stable for 1 year at -20°C from date of receipt.
Isotype: IgG
Applications: Immunohistochemistry, Immunohistochemistry (Paraffin), Radioimmune Assays (RIA), Western Blot
Conjugate: Unconjugated
Formulation: Rabbit polyclonal antiserum with 0.05% sodium azide.
Gene Symbols: Acan;Agc;Agc1
Immunogen: GST-tagged recombinant fragment corresponding to 213 amino acids from the C-terminal half of rat Aggrecan.
Purification Method: Unpurified
Regulatory Status: RUO
Primary or Secondary: Primary
Target Species: Rat
Form: Serum
Antigen:
Aggrecan
Classification:
Polyclonal
Dilution:
Radioimmunoassay Analysis: A representative lot detected Aggrecan in Postnatal rat brain (Milev, P., et. al. (1998). Biochem Biopys Res Commun. 247(2):207-12).Immunohistochemistry Analysis: A representative lot detected Aggrecan in Embryonic day 16 rat eye, P0, P9 and adult rat retina (Popp, S., et. al. (2004). Exp Eye Res. 79(3):351-6) and Embryonic day 16, 19 rat brain and postnatal day 7 cerebellum, embryonic day 19 spinal cord (Popp, S., et. al. (2003). Dev Dyn. 227(1):143-9).Western Blotting Analysis: A representative lot detected Aggrecan in purified proteoglycans from a PBS extract of 7-day rat brain with chondroitinase ABC treatment (Popp, S., et. al. (2003). Dev Dyn. 227(1):143-9).
Gene Alias:
Aggrecan core protein;Cartilage-specific proteoglycan core protein;CSPCP
Host Species:
Rabbit
Molecular Weight of Antigen:
221.12 kDa calculated
Quantity:
25 μL
Research Discipline:
Cell Structure
Test Specificity:
This rabbit polyclonal antibody detects aggrecan in rat eye sections.
Content And Storage:
Stable for 1 year at -20°C from date of receipt.
Isotype:
IgG
Applications:
Immunohistochemistry, Immunohistochemistry (Paraffin), Radioimmune Assays (RIA), Western Blot
Conjugate:
Unconjugated
Formulation:
Rabbit polyclonal antiserum with 0.05% sodium azide.
Gene Symbols:
Acan;Agc;Agc1
Immunogen:
GST-tagged recombinant fragment corresponding to 213 amino acids from the C-terminal half of rat Aggrecan.
Purification Method:
Unpurified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Target Species:
Rat
Form:
Serum