MilliporeSigma™ anti-Thrombospondin Clone: A6.1,

Description

• Specifically detects Thrombospondin Clone: A6.1 in Bovine, Canine, Equine, Human, Porcine, Rat, Sheep samples, and it is validated for Flow Cytometry, Immunofluorescence, Immunohistochemistry (Frozen), Neutralization, Immuno Blotting Thrombospondin (TSP) is a ∽450kDa glycoprotein synthesized by platelets, as well as by monocytes, macrophages, fibroblasts and endothelial cells
• Although TSP is the major α-granule protein of human platelets, the concentration of the protein in circulating plasma is quite low
• Upon stimulation of platelets, the TSP is expressed on the cell surface where it plays a role in platelet aggregation and other cell-cell interactions
• Studies show that the platelet-monocyte association has been demonstrated to be mediated by the interaction of TSP on the platelet surface with a monocyte TSP receptor
• The receptor has been identified immunologically as glycoprotein IV, also known as GPIIIb and CD36, a ∽90kDa membrane glycoprotein expressed on platelets, endothelial cells, erythrocytes, monocytes, and some human tumor cells lines but not on lymphocytes or granulocytes
• Recent studies have shown that TSP-1 is a naturally occurring inhibitor of angiogenesis whose actions are mediated by CD36, found on microvascular endothelial cells.