BDB552467

TNF Mouse anti-Human, NA/LE, Unlabeled, Clone: MABTNF-A5, BD

Manufacturer: BD Biosciences

Select a Size

Pack Size SKU Availability Price
Each of 1 BDB552467-Each-of-1 In Stock ₹ 38,844.24

BDB552467 - Each of 1

₹ 38,844.24

In Stock

Quantity

1

Base Price: ₹ 38,844.24

GST (18%): ₹ 6,991.963

Total Price: ₹ 45,836.203

Antigen

TNF

Classification

Monoclonal

Concentration

1.0mg/mL

Formulation

No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2μm sterile filtered. Endotoxin level is ≤0.01 EU/μg (≤0.001 ng/μg) of protein as determined by the LAL assay.

Immunogen

Recombinant human TNF protein

Quantity

0.5 mg

Research Discipline

Immunology

Target Species

Human

Isotype

IgG2a κ

Applications

Neutralization

Clone

MABTNF-A5

Conjugate

Unconjugated

Host Species

Mouse

Purification Method

Affinity Purified

Regulatory Status

RUO

Primary or Secondary

Primary

Content And Storage

Store undiluted at 4°C

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Description

  • The MABTNF-A5 antibody, formerly known as 5N, reacts with human tumor necrosis factor, TNF (aka, TNF-α and TNFSF2)
  • TNF is a multifunctional cytokine involved in a variety of immune and inflammatory responses including hemorrhagic necrosis of tumors, septic shock, fever and autoimmune diseases
  • TNF can regulate the growth and differentiation of many different cell types
  • It is produced by different activated cell types including macrophages, T lymphocytes, NK cells, dendritic cells, endothelial cells, peripheral blood leukocytes, osteoblasts, astrocytes, mast cells, Kupffer cells, smooth muscle cells, fibroblasts and certain tumor cells
  • TNF exists in two biologically active forms, i.e., transmembrane and soluble forms
  • Upon activation, cells express transmembrane TNF glycoproteins that associate as homotrimeric complexes
  • After enzymatic cleavage, the extracellular region of membrane TNF sheds as a soluble homotrimer
  • The biologically active form of TNF has been reported to be a trimer
  • The immunogen used to generate the MABTNF-A5 hybridoma was purified recombinant human TNF
  • This is an extraordinarily potent neutralizing antibody that is reportedly also useful for ELISA measurements of human TNF
  • Host Species: Mouse Clone: MABTNF-A5 Isotype: IgG2a κ Species Reactivity: Human Immunogen: Recombinant human TNF protein Functional Assay, Neutralization

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Antigen:
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Classification:
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Concentration:
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Formulation:
No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2μm sterile filtered. Endotoxin level is ≤0.01 EU/μg (≤0.001 ng/μg) of protein as determined by the LAL assay.

Immunogen:
Recombinant human TNF protein

Quantity:
0.5 mg

Research Discipline:
Immunology

Target Species:
Human

Isotype:
IgG2a κ

Applications:
Neutralization

Clone:
MABTNF-A5

Conjugate:
Unconjugated

Host Species:
Mouse

Purification Method:
Affinity Purified

Regulatory Status:
RUO

Primary or Secondary:
Primary

Content And Storage:
Store undiluted at 4°C

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