CD45RB Rat anti-Mouse, PE, Clone: 16A, BD

Description

• The 16A antibody reacts with an exon B-dependent epitope of CD45 lycoprotein, which is found at high density on peripheral B cells, T cytotoxic/suppressor cells,subset of T helper cells, and most thymocytes and at low density on macrophages and dendritic cells.The level of CD45RB expressionappears to decrease as T lymphocytes progress from naive to memory cells
• In addition, subpopulations of CD4+ T cells which express high and low levels ofD45RB have differentytokine secretion profiles and mediate distinct immunological functions
• CD25+D4+ regulatory T (Treg) lymphocytes which control intestinal inflammation and autoimmunity express low levels ofD45RB
• CD45 is a member of the Protein Tyrosine Phosphatase (PTP) family: Its intracellular (COOH-terminal) region contains two PTP catalytic domains, and the extracellular region is highly variable due to alternative splicing of exons (designated A, B, and C, respectively), plus differing levels of glycosylation
• The CD45 isoforms detected in the mouse are cell type-, maturation-, and activation state-specific
• The CD45 isoforms play complex roles in T-cell and B-cell antigen receptor signal transduction.