CD178 Hamster anti-Mouse, NA/LE, Unlabeled, Clone: MFL3, BD

Description

• Description The MFL3 antibody reacts with CD178 (Fas Ligand, CD95 Ligand) on all strains tested
• In the mouse, Fas Ligand is expressed on activated T cell lines and in spleen, testis, and eye
• FasL mRNA has been demonstrated at various levels in bone marrow, thymus, spleen, lymph node, lung, small intestine, testis, and uterus
• Moreover, T-cell activators, but not B-cell activators, enhanced the expression of FasL mRNA in splenocytes; and FasL mRNA was restricted to the T-cell lineage among a panel of cell lines from lymphoid tissues
• Fas Ligand is not functional in mice homozygous for the gld (generalized lympho-proliferative disease) mutation; these mice cannot limit the expansion of activated lymphocytes and develop autoimmune disease
• Fas Ligand is a member of the TNF/NGF family, which binds to CD95 (Fas), inducing apoptotic cell death
• This Fas/Fas Ligand interaction is believed to participate in T-cell development, the regulation of immune responses, and cell-mediated cytotoxic mechanisms
• There is mounting evidence that Fas Ligand is also proinflammatory, mediating neutrophil extravasation and chemotaxis
• Fas Ligand is released from the surface of transfectant cells by metalloproteinases, and the soluble Fas Ligand may block the activities of the membrane-bound molecule
• The MFL3 mAb has been reported to efficiently inhibit the cytotoxicity of mouse Fas Ligand-transfected cells against human Fas-transfected cells
• This hamster mAb to a mouse leukocyte antigen does not cross-react with rat leukocytes.