CD119 Mouse anti-Human, Unlabeled, Clone: GIR-208, BD

Description

• The GIR-208 antibody recognizes the extracellular region of CD119 which is also known as the alpha chain subunit (80-95 kDa glycoprotein) of the human interferon-γ receptor (IFN-γRα)
• The functionally active-form of the human IFN-γ receptor consists of two (or more) subunits, with IFN-γRα responsible for IFN-γβ chains required for the transduction of biologic responses
• The IFN-γ receptor α chain (CD119) is expressed on the surface of most human cells (except mature erythrocytes) including monocytes, macrophages, T cells, B cells, NK cells, neutrophils, fibroblasts, epithelial cells, and endothelium
• Binding of 125I-labeled GIR-208 antibody to IFN-γRα+ cells is reported to be specifically inhibited in the presence of excess IFN-γ
• GIR-208 does not cross react with IFN-γ as tested by ELISA
• The ability of this antibody to bind to IFN-γ receptors of species other than human has not been determined
• The immunogen used to generate this hybridoma was human IFN-γRα purified from human placenta
• The GIR- 208 has been reported to block the binding of 125I-human IFN-γto IFN-γRα+ cells as well as purified, soluble human IFN-γRα
• GIR-208 is a neutralizing antibody that has been shown to neutralize the anti-viral activity of IFN-γon WISH cells in a dose-dependent fashion.