BDB558242
Stat6 (pY641) Mouse anti-Mouse, Alexa Fluor 647, Clone: J71-773.58.11, BD
Manufacturer: BD Biosciences
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | BDB558242-Each-of-1 | In Stock | ₹ 26,309.70 |
BDB558242 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 26,309.70
GST (18%): ₹ 4,735.746
Total Price: ₹ 31,045.446
Antigen
Stat6 (pY641)
Classification
Monoclonal
Conjugate
Alexa Fluor 647
Host Species
Mouse
Purification Method
Affinity Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Content And Storage
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Applications
Flow Cytometry
Clone
J71-773.58.11
Formulation
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Immunogen
Phosphorylated Mouse STAT6 (Y641) Peptide
Quantity
50 Tests
Research Discipline
Cell Biology
Target Species
Mouse
Isotype
IgG1 κ
Description
- STATs (signal transducers and activators of transcription) are critical mediators of the biologic activity of cytokines including Interleukins (IL) 2-5, IL-7, IL-15, GM-CSF, erythropoietin and growth hormone
- Ligand-receptor interaction leads to activation of constitutively associated JAK family kinases and subsequent recruitment/activation of STATs by tyrosine phosphorylation
- Active STATs then move to the nucleus to promote transcription of cytokine-inducible genes
- Seven STAT proteins have been cloned, each of which is differentially expressed and/or activated in a cytokine-specific and cell type-specific manner
- Stat6 plays an important role in signaling pathways that lead to thedifferentiation of T helper type 2 (Th2) cells from uncommitted CD4 T cell precursors
- Moreover, IL-4, secreted by activated T lymphocytes, basophils, and mast cells, induces specific gene expression via the induction of tyrosine phosphorylation of Stat6 at tyrosine 641 (Y641)
- The SH3:SH2 domain of Stat6 associates with tyrosine-phosphorylated IL-4 receptor and the proximal Jak kinase phosphorylates Stat6 at Y641 on the C-terminal side of the SH2 domain
- Stat6 is then released from the receptor, dimerizes, and is thought to contact the basal transcription machinery by binding to p300/CBP
- While Stat6 is widely expressed in human tissues, it exhibits elevated expression in peripheral blood lymphocytes, colon, intestine, ovary, prostate, thymus, spleen, kidney, liver, lung, and placenta
- The J71-773.58.11 antibody recognizes mouse Stat6 phosphorylated at Y641
- This antibody is routinely tested by western blot analysis
- Other applications were tested at BD Biosciences Pharmingen during antibody development only or reported in the literature
- Host Species: Mouse Clone: J71-773.58.11 Isotype: IgG1, κ Cross Reactivity: Mouse Intracellular Staining
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Show Difference
Antigen: Stat6 (pY641)
Classification: Monoclonal
Conjugate: Alexa Fluor 647
Host Species: Mouse
Purification Method: Affinity Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Applications: Flow Cytometry
Clone: J71-773.58.11
Formulation: Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Immunogen: Phosphorylated Mouse STAT6 (Y641) Peptide
Quantity: 50 Tests
Research Discipline: Cell Biology
Target Species: Mouse
Isotype: IgG1 κ
Antigen:
Stat6 (pY641)
Classification:
Monoclonal
Conjugate:
Alexa Fluor 647
Host Species:
Mouse
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Applications:
Flow Cytometry
Clone:
J71-773.58.11
Formulation:
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Immunogen:
Phosphorylated Mouse STAT6 (Y641) Peptide
Quantity:
50 Tests
Research Discipline:
Cell Biology
Target Species:
Mouse
Isotype:
IgG1 κ
Antigen: α-Synuclein (pY125)
Classification: Monoclonal
Conjugate: Unconjugated
Host Species: Mouse
Purification Method: Affinity Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C
Applications: Western Blot
Clone: I57-628
Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
Immunogen: Phosphorylated peptide corresponding to the region including the Tyrosine 125 residue of α-Synuclein
Quantity: 0.1 mg
Research Discipline: Cell Biology
Target Species: Human
Isotype: IgG2b κ
Antigen:
α-Synuclein (pY125)
Classification:
Monoclonal
Conjugate:
Unconjugated
Host Species:
Mouse
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C
Applications:
Western Blot
Clone:
I57-628
Formulation:
Aqueous buffered solution containing ≤0.09% sodium azide.
Immunogen:
Phosphorylated peptide corresponding to the region including the Tyrosine 125 residue of α-Synuclein
Quantity:
0.1 mg
Research Discipline:
Cell Biology
Target Species:
Human
Isotype:
IgG2b κ
Antigen: Stat4 (pY693)
Classification: Monoclonal
Conjugate: PE
Host Species: Mouse
Purification Method: Affinity Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Applications: Flow Cytometry
Clone: 38/P-STAT4
Formulation: Aqueous buffered solution containing BSA, protein stabilizer, and ≤0.09% sodium azide.
Immunogen: Phosphorylated Human Stat4 (pY693)
Quantity: 50 Tests
Research Discipline: Cell Biology
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Regulatory Status:
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Primary or Secondary:
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Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Applications:
Flow Cytometry
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Formulation:
Aqueous buffered solution containing BSA, protein stabilizer, and ≤0.09% sodium azide.
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Quantity:
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Research Discipline:
Cell Biology
Target Species:
Human, Mouse
Isotype:
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Antigen: C3a
Classification: Monoclonal
Conjugate: Unconjugated
Host Species: Rat
Purification Method: Affinity Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C
Applications: ELISA
Clone: I87-1162
Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
Immunogen: __
Quantity: 0.1 mg
Research Discipline: Immunology
Target Species: Mouse
Isotype: IgG1 κ
Antigen:
C3a
Classification:
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Conjugate:
Unconjugated
Host Species:
Rat
Purification Method:
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Regulatory Status:
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Primary or Secondary:
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Content And Storage:
Store undiluted at 4°C
Applications:
ELISA
Clone:
I87-1162
Formulation:
Aqueous buffered solution containing ≤0.09% sodium azide.
Immunogen:
__
Quantity:
0.1 mg
Research Discipline:
Immunology
Target Species:
Mouse
Isotype:
IgG1 κ