BDB558527
Btk Mouse anti-Human, PE, Clone: 53/BTK, BD
Manufacturer: BD Biosciences
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | BDB558527-Each-of-1 | In Stock | ₹ 27,036.96 |
BDB558527 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 27,036.96
GST (18%): ₹ 4,866.653
Total Price: ₹ 31,903.613
Antigen
Btk
Classification
Monoclonal
Conjugate
PE
Host Species
Mouse
Purification Method
Affinity Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Content And Storage
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Applications
Flow Cytometry
Clone
53/BTK
Formulation
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Immunogen
Human N-terminal Btk Recombinant Protein
Quantity
50 Tests
Research Discipline
Cell Biology
Target Species
Human
Isotype
IgG2a
Description
- B ruton's t yrosine k inase (Btk) is a nonreceptor tyrosine kinase whose function is critical for proper B cell development and signaling
- It is a member of the Tec family of kinases which includes Tec and Itk
- This family is similar to the src family of tyrosine kinases
- However, Tec family members lack the N-terminal myristylation site and the regulatory C-terminal tyrosine that are found in src proteins
- In addition to an N-terminal pleckstrin homology (PH) domain, the Tec proteins contain Src homology domains 2 and 3 (SH2 and SH3) and a stretch of 60-80 amino acids between the PH and SH3 domains termed the Tec homology domain
- The activity of Btk is regulated by Src-mediated phosphorylation of the kinase domain at tyrosine 551
- This event induces Btk kinase activity and subsequent autophosphorylation at tyrosine 223 in the SH3 domain
- Phosphorylated Btk then associates with the cell membrane via the interaction of the PH domain with phosphatidylinositol 3, 4, 5-triphosphate
- The PH domain is essential for proper activation and function of Btk
- A mutation in the PH domain results in Xid, murine X-linked immunodeficiency, and human X-linked agammaglobulinemia.
Compare Similar Items
Show Difference
Antigen: Btk
Classification: Monoclonal
Conjugate: PE
Host Species: Mouse
Purification Method: Affinity Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Applications: Flow Cytometry
Clone: 53/BTK
Formulation: Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Immunogen: Human N-terminal Btk Recombinant Protein
Quantity: 50 Tests
Research Discipline: Cell Biology
Target Species: Human
Isotype: IgG2a
Antigen:
Btk
Classification:
Monoclonal
Conjugate:
PE
Host Species:
Mouse
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Applications:
Flow Cytometry
Clone:
53/BTK
Formulation:
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Immunogen:
Human N-terminal Btk Recombinant Protein
Quantity:
50 Tests
Research Discipline:
Cell Biology
Target Species:
Human
Isotype:
IgG2a
Antigen: Btk
Classification: Monoclonal
Conjugate: Alexa Fluor 647
Host Species: Mouse
Purification Method: Affinity Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Applications: Flow Cytometry
Clone: 53/BTK
Formulation: Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Immunogen: Human N-terminal Btk Recombinant Protein
Quantity: 50 Tests
Research Discipline: Cell Biology
Target Species: Human
Isotype: IgG2a
Antigen:
Btk
Classification:
Monoclonal
Conjugate:
Alexa Fluor 647
Host Species:
Mouse
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Applications:
Flow Cytometry
Clone:
53/BTK
Formulation:
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Immunogen:
Human N-terminal Btk Recombinant Protein
Quantity:
50 Tests
Research Discipline:
Cell Biology
Target Species:
Human
Isotype:
IgG2a
Antigen: CD205
Classification: Monoclonal
Conjugate: Unconjugated
Host Species: Mouse
Purification Method: Affinity Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C
Applications: Flow Cytometry
Clone: MG38
Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
Immunogen: __
Quantity: 0.1 mg
Research Discipline: Immunology
Target Species: Human
Isotype: IgG2b
Antigen:
CD205
Classification:
Monoclonal
Conjugate:
Unconjugated
Host Species:
Mouse
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C
Applications:
Flow Cytometry
Clone:
MG38
Formulation:
Aqueous buffered solution containing ≤0.09% sodium azide.
Immunogen:
__
Quantity:
0.1 mg
Research Discipline:
Immunology
Target Species:
Human
Isotype:
IgG2b
Antigen: RAB27
Classification: Monoclonal
Conjugate: Unconjugated
Host Species: Mouse
Purification Method: Affinity Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C
Applications: Western Blot
Clone: 20.1/RAB27
Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
Immunogen: Human Rab27A Recombinant Protein
Quantity: 0.1 mg
Research Discipline: Cell Biology
Target Species: Human
Isotype: IgG1 κ
Antigen:
RAB27
Classification:
Monoclonal
Conjugate:
Unconjugated
Host Species:
Mouse
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C
Applications:
Western Blot
Clone:
20.1/RAB27
Formulation:
Aqueous buffered solution containing ≤0.09% sodium azide.
Immunogen:
Human Rab27A Recombinant Protein
Quantity:
0.1 mg
Research Discipline:
Cell Biology
Target Species:
Human
Isotype:
IgG1 κ