CD29 Rat anti-Mouse, Unlabeled, Clone: KMI6, BD

Description

• The KMI6 antibody reacts with the 130-kDa integrin ß1 chain (CD29)
• CD29 is expressed on the cell surface as a heterodimer with one of the distinct integrin achains
• With a1 through a6 (CD49a through CD49f), it forms the VLA-1 through VLA-6 complexes, respectively, and with av (CD51), it forms avß1 integrin
• It also associates with the integrin a7, a8, and a9 chains in non-lymphoid tissues
• As a result, CD29 has a broad tissue distribution, including leukocytes, endothelia, smooth muscle, epithelia, and oocytes
• The epitope recognized by the KMI6 mAb can be detected by immunoblot in unreduced extracts from a variety of cells and tissues having a number of different ß1-integrin heterodimer combinations
• However, the epitope is not well expressed on the surface of the majority of hematopoietic cells
• It is detected on the surface of fetal liver cells, some bone marrow stromal cells, and some cultured hematopoietic cell lines, including P815 and PA6
• Surface expression of the CD29 epitope recognized by mAb KMI6 on thymocytes and T lymphocytes appears to be developmentally regulated, and KMI6 antibody enhances the adhesion of KMI6 thymocytes to fibronectin and laminin.