SLP-76 Mouse, PE, Clone: H3, BD

Description

• SLP-76 ( S H2 domain-containing L eukocyte P rotein of 76 kDa) is a tyrosine phosphoprotein that is involved in the T cell receptor (TCR)-mediated intracellular signaling pathway
• It may be involved in the signaling pathways of other peripheral blood leukocytes; thymic/splenic cells; and in human T, B, and monocytic cell lines
• SLP-76 consists of several motifs that signify its importance in protein-protein interactions involved in intracellular signaling pathways, such as the SH2 domain in the C-terminus, the three amino-terminus 17-amino acid repeats with conserved tyrosine and acidic residues (DYE(S/P)P), and a proline rich region
• SLP-76 has been shown to associate with Gads, Grb2, PLC g 1, SLAP-130, and Vav, all of which are part of the signaling cascade in T lymphocytes
• An early event in the T cell activation pathway is the phosphorylation, by the Syk-family kinase ZAP-70, of SLP-76 at the three conserved tyrosine motifs, which then mediate interactions with downstream effectors
• The H3 monoclonal antibody recognizes SLP-76, regardless of phosphorylation status.