BDB560191
Stat1 (pS727) Mouse, Alexa Fluor 488, Clone: K51-856, BD
Manufacturer: BD Biosciences
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | BDB560191-Each-of-1 | In Stock | ₹ 30,749.50 |
BDB560191 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 30,749.50
GST (18%): ₹ 5,534.91
Total Price: ₹ 36,284.41
Antigen
Stat1 (pS727)
Classification
Monoclonal
Conjugate
Alexa Fluor 488
Host Species
Mouse
Purification Method
Affinity Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Content And Storage
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Applications
Flow Cytometry
Clone
K51-856
Formulation
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Immunogen
Phosphorylated Human Stat1 Peptide
Quantity
50 Tests
Research Discipline
Cell Biology
Target Species
Human, Mouse
Isotype
IgG1 κ
Description
- Stat (Signal transducer and activators of transcription) proteins are critical mediators of the biologic activity of cytokines, including interleukins, interferons, erythropoietin, and growth factors
- Ligand-receptor interaction leads to activation of constitutively associated JAK family kinases and subsequent recruitment/activation of Stat proteins by tyrosine phosphorylation
- Active Stat proteins then move to the nucleus to promote transcription of cytokine-inducible genes
- Seven Stat proteins have been cloned, each of which is differentially expressed and/or activated in a cytokine-specific and cell type-specific manner
- Stat1 and Stat2 are components of the ISGF3 (Interferon-Stimulated Gene Factor 3) complex, which is the primary transcription activator induced by the binding of the interferon to a specific cell-surface receptor
- Stat1 has two alternatively spliced isoforms, 91kDa Stat1α and 84kDa Stat1β; Stat1α has 38 additional C-terminal amino acids
- In response to the binding of IFNα, IFNγ, EGF, PDGF, or CSF-1 to their respective receptors, the Stat1 subunits become tyrosine-phosphorylated at Y701, and the complex is translocated to the nucleus
- This results in the formation of an active complex that includes the DNA-binding p48 subunit
- This complex is responsible for modulating the transcription of the interferon-stimulated genes (ISGs)
- Furthermore, phosphorylation of serine 727 (S727) of Stat1 may occur in response to pathogens, cytokines, UV irradiation, and engagement of T and B cell antigen receptors
- This second phosphorylation event is necessary for fully effective activation of transcription and may differentially regulate gene activation by interacting with other regulatory factors, such as p53 in the apoptotic pathway
- The K51-856 monoclonal antibody recognizes the phosphorylated S727 in the C-terminal transactivating domain of human Stat1α; this site is not present in Stat1β
- Host Species: Mouse Clone: K51-856 Isotype: IgG1 κ Species Reactivity: Human Immunogen: Phosphorylated Human Stat1 Peptide Intracellular Staining
Compare Similar Items
Show Difference
Antigen: Stat1 (pS727)
Classification: Monoclonal
Conjugate: Alexa Fluor 488
Host Species: Mouse
Purification Method: Affinity Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Applications: Flow Cytometry
Clone: K51-856
Formulation: Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Immunogen: Phosphorylated Human Stat1 Peptide
Quantity: 50 Tests
Research Discipline: Cell Biology
Target Species: Human, Mouse
Isotype: IgG1 κ
Antigen:
Stat1 (pS727)
Classification:
Monoclonal
Conjugate:
Alexa Fluor 488
Host Species:
Mouse
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Applications:
Flow Cytometry
Clone:
K51-856
Formulation:
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Immunogen:
Phosphorylated Human Stat1 Peptide
Quantity:
50 Tests
Research Discipline:
Cell Biology
Target Species:
Human, Mouse
Isotype:
IgG1 κ
Antigen: TRA-1-60
Classification: Monoclonal
Conjugate: PE
Host Species: Mouse
Purification Method: Affinity Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Applications: Flow Cytometry
Clone: TRA-1-60
Formulation: Aqueous buffered solution containing BSA, protein stabilizer, and ≤0.09% sodium azide.
Immunogen: Human Embryonal Carcinoma Cell Line
Quantity: 100 Tests
Research Discipline: Cell Biology
Target Species: Human, Rhesus Monkey
Isotype: IgM κ
Antigen:
TRA-1-60
Classification:
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Conjugate:
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Host Species:
Mouse
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Applications:
Flow Cytometry
Clone:
TRA-1-60
Formulation:
Aqueous buffered solution containing BSA, protein stabilizer, and ≤0.09% sodium azide.
Immunogen:
Human Embryonal Carcinoma Cell Line
Quantity:
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Cell Biology
Target Species:
Human, Rhesus Monkey
Isotype:
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Antigen: TRA-1-81
Classification: Monoclonal
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Host Species: Mouse
Purification Method: Affinity Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Applications: Flow Cytometry
Clone: TRA-1-81
Formulation: Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Immunogen: Human Embryonal Carcinoma Cell Line
Quantity: 100 Tests
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Antigen:
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Purification Method:
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Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Applications:
Flow Cytometry
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Formulation:
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Immunogen:
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Quantity:
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Isotype:
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Classification: Monoclonal
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Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
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Formulation: Aqueous buffered solution containing BSA, protein stabilizer, and ≤0.09% sodium azide.
Immunogen: Human polymorphonuclear leukocytes
Quantity: 100 Tests
Research Discipline: Immunology
Target Species: Baboon, Cynomolgus, Human, Rhesus Monkey
Isotype: IgG1 κ
Antigen:
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Classification:
Monoclonal
Conjugate:
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Host Species:
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Purification Method:
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Regulatory Status:
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Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Applications:
Flow Cytometry
Clone:
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Formulation:
Aqueous buffered solution containing BSA, protein stabilizer, and ≤0.09% sodium azide.
Immunogen:
Human polymorphonuclear leukocytes
Quantity:
100 Tests
Research Discipline:
Immunology
Target Species:
Baboon, Cynomolgus, Human, Rhesus Monkey
Isotype:
IgG1 κ