BDB560286
4EBP1 (pT36/pT45) Mouse, Alexa Fluor 647, Clone: M31-16, BD
Manufacturer: BD Biosciences
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | BDB560286-Each-of-1 | In Stock | ₹ 28,257.50 |
BDB560286 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 28,257.50
GST (18%): ₹ 5,086.35
Total Price: ₹ 33,343.85
Antigen
4EBP1 (pT36/pT45)
Classification
Monoclonal
Conjugate
Alexa Fluor 647
Formulation
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Immunogen
Phosphorylated Human 4EBP1 (pT45) Peptide
Quantity
50 Tests
Research Discipline
Cell Biology
Target Species
Human, Mouse, Rat
Isotype
IgG1 κ
Applications
Flow Cytometry
Clone
M31-16
Description
4E-BP1. EIF4EBP1, P/OKCL.6, PHAS-I, PHAS-1
Host Species
Mouse
Purification Method
Affinity Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Content And Storage
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Description
- The eukaryotic translation initiation factor 4E - B inding P rotein hosphorylated h eat- and a cid- s table protein (PHAS-I or PHAS-1), and it is regulated by insulin
- It is a member of the eIF4E-Binding Protein Family, which also includes the proteins 4EBP2 and 4EBP3
- 4EBP1 binds with e ukaryotic translation Initiation Factor 4E (eIF4E), which prevents its assembly into the eIF4E complex and inhibits cap-dependent translation
- When 4EBP1 is phosphorylated, this binding is disrupted, allowing cap-dependent translation to be activated
- Phosphorylation of 4EBP1 is required for protein synthesis, and it mediates the regulation of protein translation by stimuli that signal through the phosphoinositide 3 (PI3) kinase pathway
- We found that threonines 36 and 45 (T36/T45) are phosphorylated in resting human peripheral blood mononuclear cells
- PI3 kinase inhibitors, such as LY294002 down-regulate the phosphorylation level of 4EBP1 (pT36/pT45)
- The M31-16 monoclonal antibody recognizes the phosphorylated T36 and T45 of activated human 4EBP1
- The orthologous phosphorylation sites in mouse and rat 4EBP1 are T35 and T44.
Compare Similar Items
Show Difference
Antigen: 4EBP1 (pT36/pT45)
Classification: Monoclonal
Conjugate: Alexa Fluor 647
Formulation: Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Immunogen: Phosphorylated Human 4EBP1 (pT45) Peptide
Quantity: 50 Tests
Research Discipline: Cell Biology
Target Species: Human, Mouse, Rat
Isotype: IgG1 κ
Applications: Flow Cytometry
Clone: M31-16
Description: 4E-BP1. EIF4EBP1, P/OKCL.6, PHAS-I, PHAS-1
Host Species: Mouse
Purification Method: Affinity Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Antigen:
4EBP1 (pT36/pT45)
Classification:
Monoclonal
Conjugate:
Alexa Fluor 647
Formulation:
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Immunogen:
Phosphorylated Human 4EBP1 (pT45) Peptide
Quantity:
50 Tests
Research Discipline:
Cell Biology
Target Species:
Human, Mouse, Rat
Isotype:
IgG1 κ
Applications:
Flow Cytometry
Clone:
M31-16
Description:
4E-BP1. EIF4EBP1, P/OKCL.6, PHAS-I, PHAS-1
Host Species:
Mouse
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Antigen: 4EBP1 (pT36/pT45)
Classification: Monoclonal
Conjugate: Alexa Fluor 488
Formulation: Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Immunogen: Phosphorylated Human 4EBP1 (pT45) Peptide
Quantity: 50 Tests
Research Discipline: Cell Biology
Target Species: Human, Mouse, Rat
Isotype: IgG1 κ
Applications: Flow Cytometry
Clone: M31-16
Description: 4E-BP1. EIF4EBP1, P/OKCL.6, PHAS-I, PHAS-1
Host Species: Mouse
Purification Method: Affinity Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Antigen:
4EBP1 (pT36/pT45)
Classification:
Monoclonal
Conjugate:
Alexa Fluor 488
Formulation:
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Immunogen:
Phosphorylated Human 4EBP1 (pT45) Peptide
Quantity:
50 Tests
Research Discipline:
Cell Biology
Target Species:
Human, Mouse, Rat
Isotype:
IgG1 κ
Applications:
Flow Cytometry
Clone:
M31-16
Description:
4E-BP1. EIF4EBP1, P/OKCL.6, PHAS-I, PHAS-1
Host Species:
Mouse
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Antigen: Sox2
Classification: Monoclonal
Conjugate: PE
Formulation: Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Immunogen: Human SOX2 Recombinant Protein
Quantity: 50 Tests
Research Discipline: Cell Biology
Target Species: Human
Isotype: IgG2a
Applications: Flow Cytometry
Clone: 245610
Description: ANOP3, MCOPS3, MGC2413
Host Species: Mouse
Purification Method: Affinity Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Antigen:
Sox2
Classification:
Monoclonal
Conjugate:
PE
Formulation:
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Immunogen:
Human SOX2 Recombinant Protein
Quantity:
50 Tests
Research Discipline:
Cell Biology
Target Species:
Human
Isotype:
IgG2a
Applications:
Flow Cytometry
Clone:
245610
Description:
ANOP3, MCOPS3, MGC2413
Host Species:
Mouse
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Antigen: GFAP
Classification: Monoclonal
Conjugate: Alexa Fluor 488
Formulation: Aqueous buffered solution containing BSA, protein stabilizer, and ≤0.09% sodium azide.
Immunogen: Cow spinal cord homogenate
Quantity: 100 Tests
Research Discipline: Cell Biology
Target Species: Bovine, Canine, Chicken, Guinea Pig, Human, Mouse, Porcine, Rabbit, Rat, Sheep
Isotype: IgG2b
Applications: In vitro Assay
Clone: 1B4
Description: __
Host Species: Mouse
Purification Method: Affinity Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Antigen:
GFAP
Classification:
Monoclonal
Conjugate:
Alexa Fluor 488
Formulation:
Aqueous buffered solution containing BSA, protein stabilizer, and ≤0.09% sodium azide.
Immunogen:
Cow spinal cord homogenate
Quantity:
100 Tests
Research Discipline:
Cell Biology
Target Species:
Bovine, Canine, Chicken, Guinea Pig, Human, Mouse, Porcine, Rabbit, Rat, Sheep
Isotype:
IgG2b
Applications:
In vitro Assay
Clone:
1B4
Description:
__
Host Species:
Mouse
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.