BDB560389
SHP2 (pY542) Mouse, PE, Clone: L99-921, BD
Manufacturer: BD Biosciences
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | BDB560389-Each-of-1 | In Stock | ₹ 27,165.30 |
BDB560389 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 27,165.30
GST (18%): ₹ 4,889.754
Total Price: ₹ 32,055.054
Antigen
SHP2 (pY542)
Classification
Monoclonal
Conjugate
PE
Formulation
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Immunogen
Phosphorylated Human SHP2 Peptide
Quantity
50 Tests
Research Discipline
Cell Biology
Target Species
Human, Rat
Isotype
IgG1 κ
Applications
Flow Cytometry
Clone
L99-921
Description
PTN11, PTP1D, PTP2C, PTPN11, SH-PTP2, SH-PTP3, SHP-2, SHPTP2
Host Species
Mouse
Purification Method
Affinity Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Content And Storage
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Description
- SHP2 is a member of the cytosolic class of protein-tyrosine phosphatases (PTPs)
- SHP2 reportedly contains two SH2 domains, both of which are N-terminal to the PTP catalytic domain
- SH2 PTPs are believed to work in conjunction with protein-tyrosine kinases to maintain intracellular protein phosphotyrosine homeostasis and cell cycle progression
- The expression of SHP2 has been reported to be highest in brain, heart, and kidney
- SHP2 is phosphorylated at two C-terminal tyrosine residues: Y542 and Y580
- Phosphorylation of Y542 creates an interaction in the N-terminal SH2 domain and appears to relieve basal inhibition of the PTP, while phosphorylation at Y580 creates an interaction at the C-terminal that stimulates PTP activity
- The L99-921 monoclonal antibody recognizes the phosphorylated Y542 of SHP2 (PTP2C isoform 2)
- The homologous phosphorylation site in the PTP2Ci splice variant (isoform 1) is Y546
- The specificity of this antibody was validated by confirming, using western blot analysis, that RNA-mediated interference (RNAi) of the specific protein was able to down-regulate the expression of SHP2 (pY542)
- Host Species: Mouse Clone: L99-921 Isotype: IgG1 κ Species Reactivity: Human Immunogen: Phosphorylated Human SHP2 Peptide Intracellular Staining
Compare Similar Items
Show Difference
Antigen: SHP2 (pY542)
Classification: Monoclonal
Conjugate: PE
Formulation: Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Immunogen: Phosphorylated Human SHP2 Peptide
Quantity: 50 Tests
Research Discipline: Cell Biology
Target Species: Human, Rat
Isotype: IgG1 κ
Applications: Flow Cytometry
Clone: L99-921
Description: PTN11, PTP1D, PTP2C, PTPN11, SH-PTP2, SH-PTP3, SHP-2, SHPTP2
Host Species: Mouse
Purification Method: Affinity Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Antigen:
SHP2 (pY542)
Classification:
Monoclonal
Conjugate:
PE
Formulation:
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Immunogen:
Phosphorylated Human SHP2 Peptide
Quantity:
50 Tests
Research Discipline:
Cell Biology
Target Species:
Human, Rat
Isotype:
IgG1 κ
Applications:
Flow Cytometry
Clone:
L99-921
Description:
PTN11, PTP1D, PTP2C, PTPN11, SH-PTP2, SH-PTP3, SHP-2, SHPTP2
Host Species:
Mouse
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Antigen: Stat3
Classification: Monoclonal
Conjugate: PE
Formulation: Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Immunogen: Human Stat3 Recombinant Protein
Quantity: 50 Tests
Research Discipline: Cell Biology
Target Species: Human, Mouse, Rat
Isotype: IgG1 λ
Applications: Flow Cytometry
Clone: M59-50
Description: STAT3; Acute-phase response factor; APRF; HIES
Host Species: Mouse
Purification Method: Affinity Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Antigen:
Stat3
Classification:
Monoclonal
Conjugate:
PE
Formulation:
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Immunogen:
Human Stat3 Recombinant Protein
Quantity:
50 Tests
Research Discipline:
Cell Biology
Target Species:
Human, Mouse, Rat
Isotype:
IgG1 λ
Applications:
Flow Cytometry
Clone:
M59-50
Description:
STAT3; Acute-phase response factor; APRF; HIES
Host Species:
Mouse
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Antigen: Foxp3
Classification: Monoclonal
Conjugate: Alexa Fluor 647
Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
Immunogen: Mouse Foxp3 Recombinant Protein
Quantity: 0.1 mg
Research Discipline: Immunology
Target Species: Mouse
Isotype: IgG2b
Applications: Flow Cytometry
Clone: MF23
Description: Forkhead box p3; Forkhead box protein p3; JM2; Scurfin; Scurfy; Sf
Host Species: Rat
Purification Method: Affinity Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Antigen:
Foxp3
Classification:
Monoclonal
Conjugate:
Alexa Fluor 647
Formulation:
Aqueous buffered solution containing ≤0.09% sodium azide.
Immunogen:
Mouse Foxp3 Recombinant Protein
Quantity:
0.1 mg
Research Discipline:
Immunology
Target Species:
Mouse
Isotype:
IgG2b
Applications:
Flow Cytometry
Clone:
MF23
Description:
Forkhead box p3; Forkhead box protein p3; JM2; Scurfin; Scurfy; Sf
Host Species:
Rat
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Antigen: Foxp3
Classification: Monoclonal
Conjugate: Alexa Fluor 647
Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
Immunogen: Mouse Foxp3 Recombinant Protein
Quantity: 25 μg
Research Discipline: Immunology
Target Species: Mouse
Isotype: IgG2b
Applications: Flow Cytometry
Clone: MF23
Description: Forkhead box p3; Forkhead box protein p3; JM2; Scurfin; Scurfy; Sf
Host Species: Rat
Purification Method: Affinity Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Antigen:
Foxp3
Classification:
Monoclonal
Conjugate:
Alexa Fluor 647
Formulation:
Aqueous buffered solution containing ≤0.09% sodium azide.
Immunogen:
Mouse Foxp3 Recombinant Protein
Quantity:
25 μg
Research Discipline:
Immunology
Target Species:
Mouse
Isotype:
IgG2b
Applications:
Flow Cytometry
Clone:
MF23
Description:
Forkhead box p3; Forkhead box protein p3; JM2; Scurfin; Scurfy; Sf
Host Species:
Rat
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.